$BBg;34AJ}F2Lt6I!!4AJ}Lt!!4AJ}Lt6I!!4AJ}@lLg!!4AJ}@lLgLt6I!!4AJ}Lt@lLg!!4AJ}Lt@lLgLt6I!!Bg;34AJ}F2Lt6I!!ElMN0e3X!!o*5d!!7PMm%D%\NEK!!!Bg;3o*5d1!(B

'$BBg;3=!GlElMN0e3X5-G04[(B$B!!(B' soh-haku OHYAMA' memorial Dr. OHYAMA KAMPO PHARMACY.

$B4AJ}$r8=BeIB$K3h$+$9!*Bg;34AJ}F2Lt6I(B$B!!!!(B$B2,;3Bg3X0e3XGn;NFAEgBg3XLt3X=$;NBg;3Gn9T(B$B!!(B$B!!(B $B!!(B


$B4AJ}Lt$N$3$H$J$i2?$G$b!"$^$:!"Bg;34AJ}F2Lt6I$K$*EEOC$/$@$5$$!*(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B

$B4AJ}@lLg!!Bg;34AJ}F2Lt6I!!")#3#2#7(B-$B#0#0#2#6(B $BFJLZ8):4Ln;T6b20CgD.(B $B#2#4#3#2(B

$B!!(B$B!!(B$B!!Bg;34AJ}F2Lt6I%5%$%H%^%C%W(B

$B!V$d$C$Q$j!"4AJ}Lt$O!"87A*$5$l$?@8Lt$r!">I>u!"BN
$BCN<1$H7P83K-IY$J4AJ}@lLg!!Bg;34AJ}F2Lt6I$K!"0lEY$*EEOC$/$@$5$$!*!!#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B

* $BBg;34AJ}F2Lt6I$N4AJ}%+%&%s%;%i!<$O!"2,;3Bg3X0e3XGn;N(B $BFAEgBg3XLt3X=$;N(B $BBg;3Gn9T@h@8(B $B$G$9!#(B Dr. HIROYUKI OHYAMA$B!J(BPh.D$B!K(B.

$BBg;3Gn9T@h@8!"4AJ}7r9/AjCL$*?=9~$_%[!<%`!"Ld?GI=!!(B
$B%V%i%8%k$NA49q%M%C%H%F%l%S6I!"(B$B!!(B$B!!%V%i%8%k(B RECORD TV $B$5$s$N4AJ}!JE_Cn2FAp!K$N%I%-%e%a%s%?%j!<1G2h$NCf$G!"Bg;3Gn9T@h@8$,$4>R2p$5$l$F$$$^$9!#(B

$BBg;34AJ}F2Lt6I%G%8%?%kE9J^$N4AJ}Lt$O!"$9$Y$F0lHLMQ0eLtIJ!JBh#2N`!"Bh#3N`!K$G$9!#(B
$BBg;34AJ}F2Lt6I%G%8%?%kE9J^$NDL>o2A3J$O!"$9$Y$F%a!<%+!<4uK>>.Gd2A3J$G$9!#(B

$B!!(B

$B4AJ}Lt$N$3$H$J$i!"2?$G$b!"$^$:Bg;34AJ}F2Lt6I$K!"$4AjCL$/$@$5$$!#(B
$BFC$K!"#8#0!s0J>e$N?M$,G%?1$K@.8y$7$?;RJu4AJ}$O!"Bg;34AJ}F2Lt6I$NFC?'$K$J$C$F$$$^$9!#(B
$B#3#0Be8eH>$+$i#4#0BeA0H>$N=w@-$K@d;?$5$l$F$$$^$9!#!!4AJ}$NNO$G!"ITG%BN $B4AJ}$G!"$h$j7r9/$K!*!!4AJ}Lt$O!"$4<+Bp$G!"0B?4$7$F$G$-$kITG%<#NE$G$9!#!!$<$R!"$4AjCL$/$@$5$$!#(B

$B#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B



$BFC=8!'4AJ}Lt$GITG%<#NE$N@.8yN($r>e$2$k!*!!$h$$Mq;R$rB$$k!"$h$$@:;R$rB$$k!"G%?1$7$d$9$$4D6-$rB$$k!#(B

$BITG%BN $B$J$I$N8z2L$,4|BT$G$-$k!#$3$l$i$N>I>u$O!"Mq;R$NuBV$,2~A1$5$l$k!#(B
$BElMN0e3X!J4AJ}Lt!"o*5d!K$O!"2?$h$j$b>G$i$:9T$&$3$H$,Bg@Z!*!!4AJ}Lt$bo*5d$b!"8D?M:9$O$"$k$b$N$N!";~4V$r$+$1$F>/$7$:$DBN $BHqMQ$K4X$7$F$b!"4AJ}$N0lIt!J4{@=IJ!"=PMh9g$$$N4AJ}Lt!K$N$_7r9/J]81$,E,MQ$5$l$k$,!"8D?M$N>I>u!&BN $Bo*5d<#NE$O!"ITG%<#NE$,L\E*$N>l9g$OA43[<+Hq$K$J$k!#!!$b$C$H$bJ]81$N8z$/4AJ}Lt$OK|?M8~$1$K:n$i$l$F$*$j!">I>u!&BN $B4AJ}@lLgLt6I$N=ON}$7$?Lt:^;U$d@8Lt!"%(%-%::^$ND49g$,$G$-$k4AJ}@lLg0e$K!"%*!<%@!<%a%$%I$GD49g$5$l$?4AJ}Lt$K$O!"$^$C$?$/$b$C$F!"$+$J$o$J$$!#(B
$B$h$j8z2L$r>e$2$?$1$l$P!"J]81$r;H$o$:!"<+Hq$G!"<+J,$N$?$a$@$1$KD49g$5$l$?4AJ}Lt!J8D?M$NG/Np!"IBBV!">I>u!"BN $BElMN0e3X!J4AJ}Lt!"o*5d<#NE!K$N8z2L$,=P$F$/$k$H!"%?%$%_%s%0K!$d?M9) $B $B$^$?!"%[%k%b%s%P%i%s%9$,@0$&$3$H$G7n7P0[>o!J@8M}IT=g!"@8M}DK!"(BPMS$B$J$I!K$b4KOB$7!"7lN.$,NI$/$J$C$FNd$(@-$b<#$k$N$GBND4$,NI$/$J$k!#(B
$B$=$&$J$k$H!"KhF|$r5$J,$h$/2a$4$;$k$N$G%9%H%l%9$b$?$^$i$:!"@8?#:YK&$NBgE($G$"$k3h@-;@AG$rM^@)$9$k$3$H$K$b$D$J$,$k!#(B
$B860x$,ITL@$JITG%>I$N$&$ALs#9#0!s0J>e$O!"Mq;R$d@:;R$Nu!#(B
$B$3$l$i$NLdBj$r2r7h$9$k$K$O!"Aa5^$KElMN0e3X!J4AJ}Lt!"o*5d<#NE!K$G!"Mq;R!"@:;R$N $BBg;34AJ}F2Lt6I!JBg;3o*5d1!J;@_!!!K2,;3Bg3X0e3XGn;N!!FAEgBg3XLt3X=$;N!!Bg;3Gn9T(B


$B!JI,MW;v9`$r!"$45-F~$N>e!"Aw?.$7$F$/$@$5$$!#!K(B

$BBg;34AJ}F2Lt6I!!Bg;3Gn9T!!4AJ}7r9/AjCL(B
$B$*?=$79~$_MQ;f(B
$B!JLd?GI=!K(B

$B4AJ}@lLgBg;34AJ}F2Lt6I$NDL>o1D6HF|$O!"7n!"2P!"?e!"6b!"EZ$G!"#9!'#3#0!A#1#8!'#3#0$^$G!"(B
$BLZ!"F|!"=KF|$O!"M=Ls$N45
$B!!(B$B!!!\!!(B$B!!Bg;34AJ}F2Lt6I(B OCN "Page On" 2015$BG/(B 4$B7n(B12$BF|(B $B$^$G$N%"%/%;%9?t(B

$B4AJ}$r8=BeIB$K3h$+$9!*(B $B4AJ}@lLg(B $BBg;34AJ}F2Lt6I(B $B%K%e!<%9B.Js(B !!!$B!!(B

$BJ?@.#1#8G/#57n#1F|!!$5$N>&9)%K%e!<%9Bh#5#7#29f$K!"(B
$BBg;34AJ}F2Lt6I!"Bg;3Gn9T@h@8!"!V(B $B@:L?NO!a4AJ}$O@hE7$N855$!"L?$N8;!V@:!W$rK~$?$9!#(B

$B$3$l$r!"CK$O@:!"=w$O7l$H$$$&!#!W!!$N4AJ}0e3X2r@b$,!"$4>R2p$5$l$^$7$?!#!!5-;v$NFbMF$O$3$l$G$9!#(B


$BFIGd?7J9@^9~!J:4Ln;TL1?7J9!K$*$h$S2
$BBg;34AJ}F2Lt6I!"Bg;3Gn9T@h@8!"!V:#OCBj$NHnK~>I$K8z$/4AJ}Lt!W$,!"$4>R2p$5$l$^$7$?!#5-;v$NFbMF$O$3$l$G$9!#!!(B

$B$3$N4AJ}Lt$O!"HnK~>I$N?M$N>I>u!&BN

$BBg;34AJ}F2Lt6I(B Web-Page $BC4Ev(B $B@>;3$G$9!*(B Miss.Nishiyama.
$B@>;3$O!"HnK~$OBg>fIW$G$9!*(B $BBg;3@h@8$ND49g4AJ}Lt$G!"%Y%9%HBN=E$r0];}$7$F$^!A!A$9!*!!3'$5$s$b$I$&$>$*;n$7$/$@$5$$$M!*(B

$B!!(B$B!!(B

$BBg;34AJ}F2Lt6IImB0Bg;3=!GlElMN0e3X5-G04[ITG%<#NE@lLgo*5d<#NE<<(B $B40A4M=Ls@)(B 0283-22-1607

$Bo*<#NE$N8zG=!&8z2L$K6=L#$,$"$j!"$<$R;n$7$F$_$?$$$,!"o*$rBN$K;I$9$3$H$K!"$I$&$7$F$b!"Dq93$r46$8$k?M!"$3$o$$?M$K$O!"(B
$Bo*$r;I$5$:$K!"7PMm!"%D%\<#NE$,$G$-$k!";I$5$J$$o*$b$4$6$$$^$9!#!!$I$&$>$*5$7Z$K!"8fAjCL$/$@$5$$!#(B

$B5HED(B $BOBED(B $B6b5o!!!V0l?M$GG:$s$G$$$J$$$G!"0lEY!"$*EEOC$/$@$5$$$M!*!W(B

$B!!=w@-$N$?$a$NElMN0e3X(B($B4AJ}Lt!&o*5d(B)
$B!!(B$B!V8=Be=w@-$NG:$_AjCLAk8}!W(B

$B!V@V$A$c$s$,M_$7$$J}$X!W(B
$BIB1!$G$G$-$kITG%<#NE0J30$K$b!"ElMN0e3X!J4AJ}Lt!&o*5d!K$G!"(B
$B$G$-$k8z2LE*$J<#NEK!$,$"$j$^$9!#(B



$B!V@V$A$c$s$,M_$7$$J}$X!W!!IB1!$G$G$-$kITG%<#NE0J30$K$b!"ElMN0e3X!J4AJ}Lt!&o*5d!K$G$G$-$k8z2LE*$J<#NEK!$,$"$j$^$9!#(B
$BBg;34AJ}F2Lt6I$K!"$4AjCL$/$@$5$$!*!!(BTel: 0283-22-1$B#5#7#4!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B

$BIB1!$G$G$-$kITG%<#NE0J30$K$b!"ElMN0e3X!J4AJ}Lt!&o*5d!K$G$G$-$k8z2LE*$J<#NEK!$,$"$j$^$9!#(B
$BBg;34AJ}F2Lt6I$O!"FJLZ8):4Ln;T$K$"$k4AJ}@lLg$NLt6I$G$9!#o*5d1!$rJ;@_$7$F$*$j!"4AJ}Lt$Ho*5d<#NE$rJB9T$7$F9T$&$3$H$,2DG=$G$9!#(B
$BA49q$NJ}!9$+$i9b$$I>2A$rD:$-!"$3$l$^$G$K!"#1#5#0?M0J>e$NJ}$,!"G%?1$K@.8y$7$F$$$^$9!#(B
$BBg;34AJ}F2Lt6I$N%O%$%l%Y%k$JElMN0e3X!J45I>u!"BN $B$G!"!VG%?1$9$kNO!W$,!"HtLvE*$K9b$^$j!"7k2L$H$7$F!"@:0lGUEXNO$7$F$$$F$b!"$J$+$J$+G%?1$G$-$J$+$C$?!"$4IWIX$NG%?1N($,9b$^$j!"G%?1$K@.8y$7$F$$$^$9!#(B
$B2a5n$K!"4AJ}Lt!"o*5d<#NE$r!"$*;n$7$K$J$C$?J}$b!"$<$R!"0lEY!"$4AjCL$/$@$5$$!#(BTel: 0283-22-1574$B!JBg;34AJ}$G!"%$%4!JIT0B!K%J%7!K(B

$B!VBg;34AJ}F2Lt6I$NElMN0e3X!J4AJ}Lt!"o*5d!"7PMm%D%\NEK!!";X05!";RJu%^%C%5!<%8!KITG%<#NE$NFCD'!W(B

$B-!:G@hC<$NElMN0e3X!J4AJ}Lt!&o*5d!K$N $B%9%Z%7%c%j%9%H$,$8$C$/$j$H8DJLAjCL!J40A4M=Ls@)!K$7$F!":GE,$J<#NEK!$rA*Br!" $B-"B?$/$N<#NE7P83$H $B45 $BG%?1$KIT2D7g$J@8BN%(%M%k%.!<$KK~$A$??HBN$E$/$j$rE0DlE*$K%5%]!<%H!#(B
$B%[%k%b%s!&<+N'?@7P!&Be $B$=$N7k2L!"?4$HBN$NG:$_$r2r>C!"%9%H%l%9$N$J$$ITG%<#NE$G!"G%?1!"=P;:$K@.8y$7$F$$$^$9!#(B
$B-#9b$$G%?1N($,!"$"$J$?$rI,$:NI$$J}8~$KF3$-$^$9!#(B
$BD49g4AJ}LtI~MQ#2G/0JFb!J%?%$%_%s%0$K9g$o$;$?o*5d%D%\NEK! $BBg;34AJ}F2Lt6I$G$O!"IB1!$K$*$1$kITG%<#NE$d!"$=$NB>$N4AJ}Lt!"o*5d<#NE$G$bG%?1$G$-$J$+$C$?J}!9$+$i$b!"$*4n$S$N@<$r$$$?$@$$$F$*$j$^$9!#(B
$B!V855$$J@V$A$c$s$r@8$_=P$9!"%P%i%s%9$N$H$l$??4BN$E$/$j!W$r!":#F|$+$i;O$a$^$;$s$+!*!)(B
Tel: 0283-22-1574$B!JBg;34AJ}$G!"%$%4!JIT0B!K%J%7!K(B

$BBg;34AJ}F2Lt6I!"Bg;3o*5d1!$K!"K,$l$k?M!9!J$3$s$J$*5RMM$,!"$4AjCL$KK,$l$^$9!#!K(B
$B-!ITG%BNuBV$KIT0B!"G%?1$r0];}$9$kBNNO$,$J$$!"Nd$(@-BN2NO $B-"IB1!$NITG%<#NE$HElMN0e3X!J4AJ}Lt!&o*5d!K$rJ;MQ$7$?$$!aITG%<#NE$N@.2L$r9b$a$k!"BNNOA}6/0];}!"BND4$rNI$/$9$k!JI{:nMQ$KIi$1$J$$!K!"Aa$/G%?1$7$?$$!"(B
$B-#IB1!$NITG%<#NE$KDq93$,$"$k!a<+A3G%?1$r4uK>$9$k!"%[%k%b%s:^Ey!"IB1!$NLt!JI{:nMQ!K$KDq93$,$"$k!"0B?4$7$FElMN0e3X!J4AJ}Lt!&o*5d!K$r;O$a$?$$!"(B
$B0JA0$K4AJ}Lt!&o*5d<#NE$r;n$7$?$,$&$^$/$$$+$J$+$C$?!"CK@-ITG%!J6/@:!"Jd?U!"@:L?NO%"%C%W!KBN(B

$BBg;34AJ}F2Lt6I!"Bg;3o*5d1!$K!"A49q$+$i$?$/$5$s$N?M$N!"$*4n$S$N@<$r$$$?$@$$$F$*$j$^$9!#(B
$B-!$"$-$i$a$+$1$F$$$^$7$?$,!"Bg;3@h@8$N8@MU$GA08~$-$J5$;}$A$K$J$j$^$7$?!#:#$O9,$;0lGU$G$9!#!J#4#2:P!"9-Eg8)!"4AJ}Lt!K(B
$B-"#3%v7n$G$"$s$J$KMp$l$F$$$?@8M}$,@0$$!"#6%v7n$GG%?1$G$-$^$7$?!#!J#3#5:P!"J!Eg8)!"4AJ}Lt!K(B
$B-#L4$K$b;W$$$^$;$s$G$7$?!*#1?ML\!"#6%v7n$GG%?1!"#2?ML\!"#1%v7n$GG%?1!"K\Ev$K8z2L$K6C$/$P$+$j$G$9!#!J#3#6:P!"FJLZ8)!"4AJ}Lt!"o*<#NEJ;MQ!K(B
$B-$#4#1:P$G!"2?$N%H%i%V%k$b$J$/<+A3G%?1!"<+A3J,JZ!"@h@8$K$O46 $B-%D9:j8)$N1sJ}$G$9$,!"CzG+$JEEOCAjCL$G!"0B?4$7$F4AJ}$rI~MQ$G$-$^$7$?!#I~MQ#1#0%v7n$GG%?1$G$-$^$7$?!#!J#3#2:P!"D9:j8)!"4AJ}Lt!K(B
$B-&BN30 $B-'IWIX$H$b$K2?$bLdBj$"$j$^$;$s$G$7$?$,!"#3G/4V;RJu$K$a$0$^$l$^$;$s$G$7$?!#%?%$%_%s%0A08e$No*<#NE!J7PMm!"%D%\NEK!!K$G!"(B
$B$"$C$5$jG%?1$7$^$7$?!#K\Ev$KL4$_$?$$6C$-$^$7$?!#Fs?ML\$b$*4j$$$7$^$9!#!J#2#7:P!"0q>k8)!"o*<#NE$N$_!K(B
$B-(;d<+?H!"4G8n;U$N;E;v$r$7$F$$$^$7$?$,!"IB1!$NITG%<#NE$GG%?1$G$-$^$;$s$G$7$?!#?4BN$r5Y$a$k$D$b$j$G4AJ}Lt$r#8%v7nI~MQ!"(B
$B855$$b=P$F$-$?$N$G%?%$%_%s%0;~$Ko*<#NE$r $B#2?ML\$O!"4AJ}LtI~MQ#3%v7n$GG%?1!"$b$A$m$s0B;:$G$9!#:#$G$OElMN0e3XBg9%$-?M4V$K$J$j$^$7$?!#!J#3#9:P!"FJLZ8)!"4AJ}Lt!"o*<#NEJ;MQ!K(B
$B-)1sJ}$G!">/$7IT0B$b$"$j$^$7$?$,!"0U30$H$*$$$7$$4AJ}Lt$@$C$?$N$G!"KhF|7g$+$5$:I~MQ$G$-$^$7$?!##6%v7nI~MQ$GG%?1$K@.8y$7$^$7$?!#!J#3#6:P!"2-Fl8)!"4AJ}Lt!K(B
$B-*#2#0Be$+$iITG%>I$H@o$$B3$1!"$D$$$KElMN0e3X!J4AJ}Lt!&o*<#NE!"7PMm%D%\NEK!!K$GG%?1!"L5;v$K=P;:$G$-$^$7$?!#(B
$BBg;34AJ}F2Lt6I$5$s$G!"$"$-$i$a$J$$$3$H$r65$o$j$^$7$?!#!J#3#7:P!"?@F`@n8)!"4AJ}Lt!"o*<#NEJ;MQ!K(B




$B!V@V$A$c$s$,M_$7$$J}$X!W(B
$B$5$i$K!"Bg;34AJ}F2Lt6I$G$O!"GSMqF|8!::Lt$r(B
$B
$B#L#H$H$O!)(B
$BGSMqA0$K$O#L#H!J2+BN7A@.%[%k%b%s!K$H$$$&%[%k%b%s$,2 $BGSMqF|8!::Lt$OG"$KGS=P$5$l$?$3$N(BLH$B$r8!=P$9$k;nLt$GGSMqF|$r;vA0$KM=A[$9$k$3$H$,$G$-$^$9!#(B
$BG%?1$9$k$?$a$K$O<+J,$NGSMqF|$r@53N$KCN$k$3$H$,$H$F$b=EMW$G$9!#(B
$BGSMqF|$NA08e$,:G$bG%?1$7$d$9$$;~4|$G$9$+$i!"(B
$BIWIX@83h$N%?%$%_%s%0$rGSMqF|$K9g$o$;$k$3$H$,!"G%?1$X$NBh0lJb$H$J$j$^$9!#(B
LH$B$OIaCJ$+$i>/NLJ,Hg$5$l$F$$$^$9$,GSMqF|A0$K$J$k$H5^7c$K2?G\NL$bJ,Hg$5$l!"(B
$B0l5$$K%T!<%/$KC#$7$^$9!#$3$l$r(BLH$B%5!<%8$H8F$s$G$$$^$9!#(B
$BGSMqF|8!::Lt$G!"@-8r>D$N%?%$%_%s%0$r7W$j!"(B
$B$3$NA08e$K!"2!"G%?1$7$d$9$/$9$ko*5d7PMm%D%\NEK!$r $B$3$l$,ElMN0e3X$NITG%<#NE$N2&F;$G$9!#(B

$B!!FC=8!'GSMqF|8!::Lt!!(B$B!!!!FC=8!'G%?18!::Lt!!(B

$B@V$A$c$s$,$[$7$/$F$b$J$+$J$+G%?1$G$-$:$KG:$s$G$$$k$4IWIX$O$?$/$5$s$$$^$9!#?M$K$h$C$FG%?1$N$7$d$9$5$O0c$$$^$9$,!"(B

$B@V$A$c$s$,$[$7$/$F$b$J$+$J$+G%?1$G$-$:$KG:$s$G$$$k$4IWIX$O$?$/$5$s$$$^$9!#?M$K$h$C$FG%?1$N$7$d$9$5$O0c$$$^$9$,!"(B
$B$J$+$J$+G%?1$G$-$J$$J}$O!"Bg;34AJ}F2Lt6I$ND49g4AJ}Lt$G!"ITG%BN $BGSMqF|8!::Lt$G!"@-8r>D$N%?%$%_%s%0$r7W$j!"$3$NA08e$K!"2!"G%?1$7$d$9$/$9$ko*5d7PMm%D%\NEK!$r $B-!2$7$d$9$/$9$k(B
$B!J@:;R$HMq;R$,
$B2r@b(B
$B@:;R$HMq;R$,2!W!#2$9$k$^$G$N;~4|$,!VCe>24|!W!#(B
$BGSMq$5$l$?Mq;R$O!";R5\$rL\;X$7$FMq4I$r0\F0$9$k!#$3$N%?%$%_%s%0$G $BMq4I$G=P2q$C$?@:;R$HMq;R$, $B;R5\Fb$KCe$$$?2$9$k%A%c%s%9$r$&$+$,$$!"$&$^$$%?%$%_%s%0$G;R5\FbKl$KCe>2$9$k!#(B

$BG%?1$7$J$$M}M3(B
$B@-8r>D$N%?%$%_%s%0$,0-$$$?$a$K@:;R$HMq;R$,=P2q$($F$$$J$$"*GSMqF|8!::Lt$rMQ$$$F%?%$%_%s%0$r9g$o$;$k!#(B
$BGSMq$N%?%$%_%s%0$K9g$o$;$F$$$k$N$KCe>2$,5/$3$i$J$$>l9g"*$J$s$i$+$NCe>2$7$K$/$$860x$,$"$k!#(B
$B-!Mq;R$Ne$2$k$3$H$G!"G%?1$7$d$9$/$J$k!K(B
$B-"2$9$k$@$1$N%Q%o!<$,$J$$!#!J@8BN%(%M%k%.! $B-# $B-!-"-#$r!VCe>2>c32!W$H$$$&$,!"=w@-%[%k%b%s$NJ,Hg0[>o!";R5\6ZI$J$I$N4oc32(B
$B;R5\6ZI$N45I>u2~A1!"0-2=$;$:!"$=$N$^$^$N>uBV$G!"IaDL$KG%?1!"=P;:$7$F$$$^$9!#(B

$B2r7hK!(B
$B-!4AJ}Lt$G!"Mq;R$Ne$2$k$3$H$GG%?1$7$d$9$/$J$k!#!J$h$$Mq;R$r:n$k!K(B
$B-"Ce>2$7$d$9$$;R5\FbKl$O!"7l$N=d$j$,$h$/!"7lN.NL$,B?$$>uBV$,NI$$!#!J;@AG$H1IM\J,$r1?$V!K(B
$B$=$N$?$a$K$O!"4AJ}Lt!"o*5d7PMm%D%\NEK!$G!"2
$B;RJu!JG%?1!"=P;:!K$K7C$^$l$k$?$a$K:G$b=EMW$J4o41!J=w@-@8?#4o!K$NCN<1(B
$B@:;R$O@8?#O)$r>e$C$F$$$-!"Mq;R$O@8?#O)$r2<$C$F$$$/!"$^$:$O!"4AJ}$G@8?#O)$N4D6-$r@0$($k$3$H$,0lHV!aITG%BN $B-!g4!J;:F;$N0lIt!K!'@-8r;~$K$O@:;R$,J|=P$5$l$k>l=j$G$"$j!"=P;:;~$K$OB[;y$,=P$F$$$/7PO)$H$J$k!#(B
$B-";R5\!'l=j!#(B
$B-#4I!'@:;R$,Mq;R$H=P9g$$!"l=j!#(B
$B-$MqAc!'Mq;R$,:n$i$l$FJ|=P$5$l$kB!4o!#(B

$BElMN0e3X!J4AJ}Lt!&o*5d!K$G!"%[%k%b%s!"<+N'?@7P!"BeC$7$F!"(B
$B?4BN$r%j%i%C%/%9$5$;NIe$2$k!K!a:YK&$OLkL2$C$F$$$k4V$K=$I|$5$l$k!"(B
$BMq;R$NO72=$rKI$.!"e$2$k$3$H$,Bg@Z!#(B
$B$^$?!"!V%a%i%H%K%s!W$H$$$&?gL2%[%k%b%s$,!"DK$s$@:YK&$r=$I|$7Mq;R$r;@2=$+$i $B$D$^$j!"4AJ}$G!"%a%i%H%K%s$NJ,Hg$r3h@-2=$9$l$P?gL2$N
$BElMN0e3X!J4AJ}Lt!&o*5d!K$G!"!V1w7l!W!V7l$NF;>I!W!VNd$(@-!W$r2~A1!JNd$(@-2~A1$OElMN0e3X$NF@0U$H$9$k$H$3$m!"0lHV$G$9!#!K(B
$B=w@-$KB?$$Nd$(@-$O!"Mq;R$N $B!v6X1l$9$k!a%?%P%3$K$O?t@i $B$^$?%?%P%3$NFG@-$,;D$C$F$$$k4V$OMq;R$N $BElMN0e3X!J4AJ}Lt!&o*5d!K$N8z2L$,=P$K$/$/$J$k$3$H$b$"$k!#(B
$B$^$?!"7lN.$,$h$/$J$k$H!"MqAc$+$i=P$k%[%k%b%s$NJ,Hg$d;R5\Fb$N4D6-$b2~A1$9$k!#(B
$B$5$i$K!"ITG%$d;R5\FbKl>I$N0-2=860x$G$"$k2=3XJ* $B$3$N$h$&$JM-32J*e$2!"LH1V5!G=$r6/2=$9$k$3$H$G!"BN$N30$KGS=P$5$;$k(B
$B!JBNFb>t2=!"D2Fb>t2=!"D2Fb4D6-$r@0$($k!"%G%H%C%/%9!K$r@.8y$5$;$k$H$h$$!#(B
$BMq;R$N2$7$d$9$$;R5\FbKl$r:n$k$K$O!"ElMN0e3X$N $BAa4|$+$iA4?H$NNI$$>uBV$rJ]$A7QB3$7$F$$$/$3$H$,=EMW$G$"$k!#(B

$B!!!!!!!!(B$B!!!V%^%?%K%F%#!<%V%k!<$K$h$$4AJ}Lt!*!W(B
$B!!!!!!!!=P;:8e$NIT0B!">p=oIT0BDj$K$h$$$G$9!#(B
$BJlF}$r$$$C$Q$$$@$94AJ}Lt!"$D$o$j$K8z$/4AJ}Lt$"$j$^$9!*(B

$BElMN0e3X!J4AJ}Lt!&o*5d!K$GITG%$,<#$j!"(B
$B@V$A$c$s$r8+;v$K=P;:$7$??M$?$A$N

$B!!;R6!$,$G$-$kElMN0e3X(B($B4AJ}Lt!&o*5d(B)
$B!VITG%>I$NG:$_AjCLAk8}!W(B $BFC=8!'=w@-$NITG%>I$HElMN0e3X(B

$B$^$:$O!"4AJ}Lt!"o*5d$G!"G%?1$7$d$9$$4D6-$rAO$j!"ITG%BN
$B5HED(B $BOBED(B $B6b5o!!!V0l?M$GG:$s$G$$$J$$$G!"0lEY!"$*EEOC$/$@$5$$$M!*!W(B

$B!!!!!!!!>o;~
$B!!!!!!!!!!!!!!!!!!!!(B*$B2<5-!"%+%C%W%k%"%$%3%s$r%/%j%C%/$7$F$/$@$5$$!*(B
$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!(B$BITG%>I$NG:$_AjCL%U%)!<%`(B

$B!!!!!!!!!!(B$B!!FC=8!'ITG%>I$H4AJ}Lt!!!V$^$:!"4AJ}$GITG%BN
$B!!!!!!!!!!(B$B!!FC=8!'ITG%>I$N<#NEJ}K!$H8!::J}K!$K$D$$$F!"#Q!u#A!!(B

$B!!!!!!!!!!(B$B!!FC=8!'ITG%>I$NG:$_AjCLAk8}!!#Q!u#A!!!V(B $B$"$J$?$NG:$_$K$*Ez$($7$^$9!*!W(B

$B!!!!!!!!!!(B$B!!CK@-$NITG%>I$H4AJ}Lt!J6/@:!"@:;R$N1?F0G=NO$r>e$2$k!"6/$$@:;R$rBt;3:n$k!"B>!K(B

$B!!!!!!!!!!(B$B!!FC=8!'7n7PA0>I8u72!J(BPMS$B!K7n7PA06[D%>I$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'7n7PA0IT2w5$J,>c32!J(BPMDD$B!K$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!=w@-$NITG%>I$H4AJ}Lt!JL5GSMq!"7n7P0[>o!"0B;:!"N.;:!"5U;R!"93@:;R93BN!"$h$$Mq;R$rBt;3:n$k!"B>!K(B

$B!!!!!!!!(B$B!!!!MqAc5!G=ITA4!J7n7P<~4|$N0[>o$dGSMq>c32$,$"$k!a7n7PIT=g!"L57n7P!"L5GSMq!K(B

$B!!!!!!!!!!!!B?G9K&@-MqAc>I8u72!JMqAc
$B!!!!!!!!!!!!;R5\IUB04o1j!J;R5\$KIUB0$9$kMq4I!"MqAc$K:Y6]$,?/F~$71j>I$r5/$3$7$?>uBV!KMq4I1j!"MqAc1j!"(B

$B!!!!!!!!!!(B$B!!FC=8!'ITG%>I$H;R5\6ZI!!!V;R5\6ZI$r;}$C$??M$NG%?1$+$i=P;:$^$G!"!W(B

$B!!!!!!!!!!!!;R5\6ZI$rElMN0e3X!J4AJ}Lt!&o*5d!K$G9nI~$9$k!#(B

$B!!(B $BITG%>I$r>h$j1[$($kElMN0e3X!J4AJ}Lt!&o*5d!K<~4|NEK!(B

$B!!!!!!(B$B!!FC=8!'ITG%>I$K8z$/!"ElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!(B$B!!FC=8!'5]5"D47l0{Bh0l2C8:!J$-$e$&$-$A$g$&$1$D$$$s$@$$$$$A$+$2$s!K$HITG%>I!!(B

$B!!!!!!(B$B!!FC=8!'9b%W%m%i%/%A%s7l>I$H4AJ}Lt!a@^>W0{!J$;$C$7$g$&$$$s!K$H@8M}DK!aITG%>I$N860x!"(B

$B!!!!!!(B$B!!FC=8!'=w@-$N99G/4|$HElMN0e3X!J4AJ}Lt!&o*5d!K!a#4#3:P=w@-!"99G/4|>c32$"$j!"G%?14uK>(B

$B!!!!!!(B$B!!FC=8!'CK@-$N99G/4|$HElMN0e3X!J4AJ}Lt!&o*5d!K!a#6#0:PCK@-!"99G/4|>c32$"$j!";R6!$,M_$7$$(B

$B!!!!!!(B$B!!FC=8!'=w@-$NITG%>I$H4AJ}Lt!J297PEr2CL#J}!"5]5"D47l0{2C8:J}!K(B

$B!!!!!!(B$B!!FC=8!'H,DAEr2C9aIm;R!J$O$C$A$s$H$&$+$3$&$V$7!K(B


$B!!!!(B$B!!(B$BBg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B

$B!!!!(B " THE KAMPO " $B4AJ}(B
$B!!!!4AJ}Lt!!(BHow the Japanese Updated Traditional Herbal Medicine

$B!!(B$B!!M\@8!J$h$&$;$$!K$NK!!a<+$i$N0U;V$G!"<+$i$NL?$rM\$$!"$B!!(B


$B!!(B $BFC=8!'J|
$B!!!!(B$B!!!VBgFC=8!'D2Fb%U%m!<%i!"D2Fb4D6-$r@0$($k!*!W(B

$BBg;34AJ}F2Lt6I$ND49g4AJ}Lt$G!"!VD2Fb%U%m!<%i!W$r!"e:No$G7r9/E*$J!"$*2VH*$KJQ$($k!*(B
$BA16L6]#2!'F|OB8+6]#7!'0-6L6]#1!aM}A[$N%P%i%s%9!aD2Fb%U%m!<%i$,@0$($P!"H~MF$b7r9/$b:G9b$N>uBV$K!"(B
$BD2Fb%U%m!<%i$,Mp$l$k860x$r%A%'%C%/!"-!?)@83h$NMp$l!"-"JX!J$&$s$A!K$NMp$l!"-#%9%H%l%9$NB?$$@83h!"-$?gL2!"1?F0ITB-(B
$BD2Fb%U%m!<%i$,Mp$l$F$$$k$H!"-!B@$C$?$j!"$`$/$_$d$9$/$J$k!"-"?a$-=PJ*$,=P$?$j!"H)9S$l$7$d$9$/$J$k!"(B
$B-#LH1VNO$,Dc2<$9$k!"%"%l%k%.!<<@45!"%,%s$J$I$,H/>I$7$d$9$/$J$k!"(B
$B-$8}=-$dBN=-$J$I!"BN$+$i$K$*$C$F$/$k!"$*$J$i$b=-$$!#!J$K$*$$$,5$$K$J$kJ}$O!"@'Hs$4AjCL$/$@$5$$!#!K(B

$B!VD2Fb%U%m!<%i$HElMN0e3X!J4AJ}Lt!&o*5d!K!W(B

$B!!!!(B$B!!!VBgFC=8!'D2Fb%U%m!<%i!"@d9%D4!*D2Fb4D6-$r@0$($k!W!!(B
2015. 7$B7n(B $B4AJ}@lLg!!Bg;34AJ}F2Lt6I!!FIGd?7J9(B $B2 $B!W(B

$B!!!!!V(B $B@d9%D2!*!!D2Fb%U%m!<%i!"$&$=$G$7$g!A!*!!$3$s$J$K=P$k$N!)!W!!=i$a$F0{$s$@B?$/$NJ}$N6C$-$N46A[$G$9!#(B
$B!!!!!!!!!!D2$NCf$+$i%-%l%$$K$7$^$;$s$+!)!!EvE9$N$*>)$a$9$kD2Fb>t2=K!$O!"C1$KL5M}$d$j=P$9!VJXHkLt!J2<:^!K!W$G$O$"$j$^$;$s!#(B
$B!!!!!!!!!!D2$K$3$S$j$D$$$?%I%m%I%m=IJX$r%-%l%$$K$9$k!VD2Fb>t2=K!!W$G$9!#!!5$;}$A$$$$%&%s%A$7$F$^$9$+!A!)(B

$BD2Fb%U%m!<%i!!Bg;34AJ}F2Lt6I!!(B$B!VFC=8!'M}A[$N%&%s%A!JD2Fb4D6-!K!W(B

$B!VA16L6]$,$?$/$5$s$"$k?M$O!"D9@8$-$G!"@83h=,47IB$K$b$J$j$K$/$$!*!JD2Fb4D6-$r@0$($k!K!W(B



$B!!(B$B!!JXHk$H4AJ}Lt!VBN$N855$$O$*$J$+!J$*J"!K$+$i!"$h$$D2Fb4D6-$r:n$k!*!W!!(B

$B!VBgFC=8!'D2Fb%U%m!<%i!*D2Fb4D6-$r@0$($k!W(B
$B4AJ}Lt$G!"!VD2Fb%U%m!<%i!W$r!"e:No$G7r9/E*$J!"$*2VH*$KJQ$($k!*(B
$BA16L6]#2!'F|OB8+6]#7!'0-6L6]#1!aM}A[$N%P%i%s%9!"D2Fb%U%m!<%i$,@0$($P!"H~MF$b7r9/$b:G9b$N>uBV$K!"(B
$BD2Fb%U%m!<%i$,Mp$l$k860x$r%A%'%C%/!"(B
$B-!?)@83h$NMp$l!"-"JX!J$&$s$A!K$NMp$l!"-#%9%H%l%9$NB?$$@83h!"-$?gL2!"1?F0ITB-(B
$BD2Fb%U%m!<%i$,Mp$l$F$$$k$H!"(B
$B-!B@$C$?$j!"$`$/$_$d$9$/$J$k!"-"?a$-=PJ*$,=P$?$j!"H)9S$l$7$d$9$/$J$k!"(B
$B-#LH1VNO$,Dc2<$9$k!"%"%l%k%.!<<@45!"%,%s$J$I$,H/>I$7$d$9$/$J$k!"-$8}=-$dBN=-$J$I!"BN$+$i$K$*$C$F$/$k!#$*$J$i$b=-$$!#(B
$B$h$$D2Fb4D6-(B($BA16L6]$,B?$$(B)$B$H0-$$D2Fb4D6-(B($B0-6L6]$,B?$$(B=$B=IJX!"JXHk!"2 $BD2Fb4D6-(B $BFC=8-!!'H~MF$H7r9/$N%P%m%a!<%?!
$BD2Fb4D6-(B $BFC=8-"!'E0DlHf3S!VA16L6]$NB?$$?M$N%&%s%A$H0-6L6]$NB?$$?M$N%&%s%A!W(B

$B!!(B$B!!FC=8#1!'!VD2Fb4D6-$r@0$($k!*!W!!(B$B!!(B

$B!!(B$B!!FC=8#2!'!VD2FbLH1V$N$7$/$_!*!W!!(B

$B9qN)46@w>I8&5f=j$N1V3XD4::$G$O!"#2#0#1#0G/EY$K3NG'$5$l$?D24I=P7l@-BgD26]46@wJs9p$G$O!"(B
$B#O(B-$B#1#5#7$,#2#7#3#2Nc!"#O(B-$B#2#6$,#5#6#4Nc!"#O(B-$B#1#1#1$,#8#5Nc$H#O(B-$B#1#1#1$N46@wJs9p$O#O(B-$B#1#5#7$KHf$Y$4$/$o$:$+$H$J$C$F$$$^$9!#(B
$B$7$+$7:#2sIY;3!"J!0fN>8)$N0{?)E9$G?);v$r$7$?J}$N$&$A#4?M$,!"D24I=P7l@-BgD26]$K46@w$7$F;`K4$7$?=8CD?)CfFG$G!"(B
$B#O(B-$B#1#1#1$K$h$k?)CfFG$NBg5,LO$JH/@8$,7|G0$5$l$F$$$^$9!#;`K4$7$?#4?M$NJ}$O$$$:$l$bMO7l@-G"FG>I>I8u72!J(BHUS$B!K$H$J$j!"(B
$B=E>I2=$7$F$$$?;v$+$i!"(BHUS$B$NNW>2IBBV$r8r$($F!"D24I=P7l@-BgD26]$X$NBP:v$K$D$$$F@bL@$7$^$9!#(B

$BM}A[$ND2Fb4D6-$r:n$kF};@6]!'D2Fb%U%m!<%i(B
$B!J#F#K(B-$B#2#36]!a%(%s%F%m%3%C%+%9%U%'%+%j%96]!K$r9M$($k!*!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!-!D2Fb:Y6]$H(BFK-23$B!!(B

$B!!!!-"H~MF$HF};@6]!!(B

$B!!!!-#%"%l%k%.!<$HF};@6]!!(B

$B!!!!-$9b7l05$HF};@6]!!(B

$B!!!!-%(BC $B7?4N1j$HF};@6]!!(B

$B!!!!-&LH1V$HF};@6]!!(B

$B!!!!-'$,$s$HF};@6]!!(B

$B!!!!-(93$,$s:^$HF};@6]!!(B




$B!VBg;34AJ}F2(B $BFC=8(B $B$,$s$r9M$($k(B !!! $B!W(B

$B!!!!!!!!!!!!!!(B$B!!!V:G?7$,$s>pJs!W!'0dEA;R1IM\$HH/4b$N%a%+%K%:%`!J0dEA;R%l%Y%k$G$,$s$NH/@8$rM^$($k!*!K(B
$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!(B* $B%"%]%H!<%7%9!J<+A3:YK&;`!K$N%a%+%K%:%`$H%"%]%H!<%7%9$rM6F3$9$k?)IJ@.J,$K$D$$$F(B

$B!!!!!!!!!!(B$B!!FC=8!'$,$s!J0-@-?7@8J*!K$r9M$($k!*!!!!(B$B!!FC=8!'$,$s$H4AJ}Lt$r9M$($k!*(B


$B!V45I>u!"BN
$B!V$^$:$O!"$*EEOC$/$@$5$$!#!!(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!JIT0B!K%J%7!K!W(B

$B!!(B* $B$,$s$KIi$1$J$$BNNO:n$j!"!VL?$r.>>Lw904F=$(B $B!J<9I.Cf!K(B
$B!!!!!!!!!!!!3h@-;@AG!J%U%j!<%i%8%+%k!K$r>C5n$7$F!"$,$sLH1VNO$r>e$2!" $B!!!!!!!!!!!!!!!!!!:G?72J3X!V:YK&LH1V3X!W$GZ$5$l$k!VL?$r
$B!!!!!!!!!!!!!!!!!!!!!!(B$B!!$,$s4XO"7r9/?)IJ$N2r@b(B(1)
$B!!(B$B!V$,$s$KIi$1$J$$BNNO:n$j!"1dL?!"#Q#O#L2~A1!"I{:nMQKI;_!"$,$s$NLH1VAjCL!W$*?=$79~$_%U%)!<%`(B


$B!!!!!!!v(BAHCC$B$H$O!"(B$B!!!v%"%,%j%/%9$H$O!"(B $B!!!v%a%7%^%3%V$H$O!"(B$B!!!v%5%aFp9|$H$O!"(B


$B!!!!!!!v%U%3%$%@%s$H$O!"(B$B!!!v%A%c!<%,!"%+%P%N%"%J%?%1!"%7%i%+%P%?%1!"%7%Y%j%"Nn$B!!!v%W%m%]%j%9$H$O!"(B



$B!!!!!!!!!!(B$B!!$,$s4XO"7r9/?)IJ$N2r@b(B(2)

$B!!!!!!!!!!(B$B!!FC=8!'@83h=,47$rJQ$($F4b$H@o$$!"$,$s$rKI$0(B

$B!!!!!!!!!!(B$B!!FC=8!'=w@-$N4b$r9M$($k(B

$B!!!!!!!!!!(B$B!!FC=8!'$,$s$HBeBX0eNE!J4AJ}Lt!"LtAp!"1IM\Jd=u?)IJ!K(B

$B!!!!!!!!!!(B$B!!E7A3%a%7%^%3%V(B $B!V$$$^!"AI$kEA@b$N%-%N%3(B $B!W(B $B#2#1@$5*Am9g0eNE$N4z
$B!!!!!!!!!!(B$B!!88$N%-%N%3E7A3%a%7%^%3%V(B

$B!!!!!!!!!!(B$B!!%U%3%$%@%s$F!"$J$s$@$m$&!)(B

$B!!!!!!!!!!(B$B!!HDMu:,!J$P$s$i$s$3$s!K$H$O!)(B




$B!!(B$B!!Bg;34AJ}F2Lt6I(B $B8D?M>pJsJ]8n$K4X$9$k@k8@!J8D?M>pJsJ]8nJ}?K!K(B !!!

$BBg;34AJ}%V%i%s%I>&IJ$N$4>R2p(B $B?M5$$H?.Mj$N#3IJL\(B
$BKL3$F;$+$i6e=#!"2-Fl$^$G!"F|K\A49q$KBg;34AJ}$N%U%!%s$NJ}$,$$$i$C$7$c$$$^$9!*(B
$B!VBg;34AJ}$O$9$4$$!*Bg;34AJ}$N$3$l$,$h$$!*!W$H$*$C$7$c$C$F$$$?$@$$$F$*$j$^$9!#(B
$B-!Bg;34AJ}F2Lt6I!V5mN62+!J%4%j%e%&%*%&!K!W(B
$B-"Bg;34AJ}F2Lt6I!V`{6L9Q!J%Q%J%C%/%9%1%$%.%g%/!aHNGd=*N;!K"*`{6L9Q!J%+%$%[%&%1%$%.%g%/!K!W(B
$B-#Bg;34AJ}F2Lt6I!V@8Lt@=:^Fs9fJ}!J%K%4%&%[%&!K!W(B

$B!!Bg;34AJ}F2Lt6I%V%i%s%I>&IJ(B



$BBg;34AJ}F2Lt6I!!CN<1$d7P83K-IY$J4AJ}@lLg!!4AJ}7r9/AjCL!!2,;3Bg3X0e3XGn;N!!FAEgBg3XLt3X=$;N!!Bg;3Gn9T(B

$B-!Bg;3=!Gl5-G0(B $B!VBg;34AJ}F2Lt6I!&Bg;3o*5d1!!K!W(B $B$O7r9/$r4j$&?M$K!"<+A3$N?"J*$r86NA$H$7$?(B $B!V4AJ}Lt!W(B $B$r$*4+$aCW$7$^$9!#(B

$B-"$*C5$7$N(B (I"$B4AJ}Lt!&LtAp!&7r9/?)IJ(I#(B $B$,$"$j$^$7$?$i!!$*5$7Z$K!"$4AjCL(B $B2<$5$$!#(B

$B-#87A*$5$l$?(B (I"$B4AJ}Lt(B (I#$B$r(B $B!VFCJL2A3J(B $B!J3d0zM%6x!K!W(B $B$K$FHNGdCW$7$^$9!#(B

$B!VBg;34AJ}F2Lt6I!W(B $B$O(B $B8|@8>J$N4p=`$rDL2a$7;XDj$r
$B!cLt6I3+@_5v2DHV9f!!Bh#E#6#0#8#09f!!0eLtIJ@=B$6H5v2DHV9f!!Bh#E#6#0#1#89f!!0eLtIJ@=B$>5G'HV9f!!Bh#A(B-$B#2#69f!d(B


$B#2#0#1#5!!Bg;3=!Gl5-G0!!Bg;34AJ}F2Lt6I!!Bg;3o*5d1!!!E}3g

$BBg;34AJ}F2Lt6I!JElMN0e3X@lLg!J4AJ}Lt!&o*5d!K!ao*5d<#NE< $BKL3$F;$+$i6e=#!"2-Fl8)$N?M$^$G!"F|K\A49q!"MZ$+1sJ}$+$i$N$4AjCL $B3'MM$+$i$N$4?.Mj!"K\Ev$K4r$7$/;W$$$^$9!#!!;dC#$O!"$3$N;v $B8=>u$K4E$s$:$k$3$H$J$/!"F|!9?JJb$9$kElMN0e3X!":G@hC<$N4AJ}Lt!"o*5d<#NE$r$4Ds6!$G$-$k$h$&!"5;=Q8&oS!">pJs<}=8B>!"(B
$B?4$7$F!"F|!9!"EX$a$F$*$j$^$9!#!!4AJ}Lt6IE9Fb$O69$/HQ;($G!"$4LBOG$r$*$+$1$7$F!"?=$7Lu$"$j$^$;$s$,!"(B
$B$I$&$>!"$*5$7Z$K$*F~$j$/$@$5$$!#!!$^$?!"4AJ}Lt$Ho*5d<#NE$NJ;MQ$r$*9M$($N$*5RMM!"%W%i%$%P%7!<$rFC$K5$$K$J$5$k$*5RMM!"(B
$B$42HB2A40w$G$NAjCL$r4uK>$5$l$k$*5RMM$K$O!"$f$C$?$j$H$7$?!"o*5d<#NE< $B$I$&$>!"$4MhE9A0$K!";vA0M=Ls$r$*4j$$CW$7$^$9!#(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B

$B#1!KElMN0e3X!J4AJ}Lt!&o*5d!K$O!"?M4V$KK\MhHw$o$C$F$$$k@8BNKI8f%7%9%F%`!J@8L?NO!&<+A3<#L~NO!K$r3h@-2=$7Mp$l$?BN$N%P%i%s%9$r@0$($k!#(B
$B#2!KElMN0e3X!J4AJ}Lt!&o*5d!K4AJ}$O!"Fq$7$$M}O@$G$O$J$/!"45 $B9MN8$7$F!"8D?M$N>Z!JBNI>u!K$r:G=EMW;k$7$F8D?M$K9g$C$?o*5d<#NE!"4AJ}Lt$r%*!<%@!<%a%$%I$9$k$3$H$,Bg@Z$G$"$k!#(B
$B#3!KElMN0e3X!J4AJ}Lt!&o*5d!K$O!"4AJ}Lt!&o*5d$r@lLg$K3X$s$@!JC55a$7$F$$$k!K!"CN<1!"7P83!"6&$KK-IY$J?MJ*(B($B@h@8!K$rA*$V$3$H$,0lHVBg@Z$G$"$k!#(B

$BBg;34AJ}F2Lt6I!&Bg;3o*5d1!$G$O!"=iBeBg;3=!Gl@h@8$h$jEA>5$5$l$ko*5d<#NE$K2C$(!"K\3JE*$J4AJ}@y$8Lt$rCf?4$H$7$F!"4AJ}%(%-%9@=:^!"(B
$B4AJ}%(%-%9>{:^!"4AJ}Fp9Q:^!"4AJ}%-%6%_@8Lt!"L14VLtAp!"7r9/?)IJEy!"I}9-$/ $B$I$&$>$*5$7Z$K$*Ld$$9g$o$;$/$@$5$$!#(B

$BBg;3=!Gl5-G0!!Bg;34AJ}F2Lt6I!!Bg;3o*5d1!!!8\LdAjCLLr!!2qD9!!Bg;37<;J!JFsBeL\!K!!$40';"!!(B

$B!vBg;37<;J@h@8$O!"$3$l$^$G$N6H@S$r>N$(!"#2#0#0#4G/#47n#2#9F|!"F|K\9qE79D$h$j(B $B!V00F|C18w>O(B
$B!J$-$g$/$8$D$?$s$3$&$7$g$&!K!W(B" The Order of the Rising Sun, Silver Rays." $B$r

$B!vBg;37<;J@h@8$O!"$3$l$^$G$N6H@S$r>N$(!"#2#0#0#0G/#57n#2#9F|(B $BEl5~(B $B@V:d%W%j%s%9%[%F%k$K$F(B
$BC01)M::H(B $B8|@8Bg?C$h$j(B $B!V8|@8Bg?C>^!J8x=01R@8ItLg!K!W(B $B$r^$5$l$^$7$?!#(B


$B!!!!!!!!!!(B$B!!Bg;3=!Gl5-G0!VBg;34AJ}F2Lt6I!&Bg;3o*5d1!!W$N$4>R2p(B

$B!!!!!!(B$B!!Bg;34AJ}F2Lt6I!&Bg;3o*5d1!$X$N9T$-J}!!(B


$B!!!!!!(B$B!!K,LdHNGdK!$K4p$E$/I=<(!"8D?M>pJsJ]8n$K4X$9$k@k8@!J8D?M>pJsJ]8nJ}?K!K!"(B
$B!!!!!!!!!!!!!VLt6I$N4IM}$*$h$S1?1D$K4X$9$k;v9`!W!VMW;XF30eLtIJ5Z$S0lHLMQ0eLtIJ!J(BOTC$B!K$NHNGd@)EY$K4X$9$k;v9`!W(B

$B!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I(B $B?dA&?^=q!!!!!!FCA&(B $B8wJ8$r
$B!!!!!!!!!!(B$B!!!VBg;3=!Gl@h@8$HF|K\$NElMN0e3X!W!!o*5d$r8=BeIB$K3h$+$9!*Bg;3o*5d1!(B Web-Page.


$B!!!!!!!!!!(B$B!!>&IJ$N$*?=9~$_J}K!!!(B


$B!!Bg;34AJ}F2Lt6I$G!"$*
$B!J3t!K%&%A%@OB4ALt!!(B $B>>1:4AJ}!J3t!K!!(B$B!J3t!KFJK\E73$F2!!(B $B?-OB@=Lt!J3t!K!!(B $B!J3t!K7zNS>>DaF2!!(B JPS$B@=Lt!!(B $B!J3t!K%D%`%i(B

$B!!(B* $B>e5-!"#7$D$NFCLs%a!<%+!<$N>&IJ$O!"$9$Y$F$*

$BBgFC=8!'LtM\
$BBgFC=8!'LtMQ

$B!V4AJ}Lt!JLtM\ $B-!E_Cn2FAp!J>eIJ!'#1(Bg/$B#6#0#0#01_$h$j!"CfIJ!'#1(Bg/$B#5#0#0#01_$h$j!"JBIJ!'#1(Bg$B!'#4#0#0#01_$h$j!"%P%iIJ!'(B1g$B!'#3#0#0#01_$h$j!K(B
$B-"3$GO!"3$N6!J>eIJ!'#1(Bg/$B#1#0#0#01_$h$j!"CfIJ!'#1(Bg/$B#8#0#01_$h$j!"JBIJ!'#1(Bg$B!'#4#0#01_$h$j!"2 $B-#eIJ!'#1#0#0#g(B/$B#1#4#0#0#0!"JBIJ#1#0#0#g(B/$B#8#0#0#01_!"2 $B!!!!NneIJ!'#1#0#0#g(B/$B#1#4#0#0#0!"CfIJ!'#1#0#0(Bg/$B#7#0#0#01_!"JBIJ#1#0#0#g(B/$B#3#5#0#01_!K(B
$B-$eIJ!'#1(Bg/$B#3#0#0#01_!K(B
$B-%Fy=>MF!J>eIJ!'#5#0#0#g(B/$B#8#0#0#01_!K!"-&8^L#;R!J>eIJ!'#5#0#0#g(B/$B#6#0#0#01_!K!"(B
$B-'8feIJ!'#5#0#0#g(B/$B#1#6#0#0#01_!K!"@843?M;2!J>eIJ!'#5#0#0#g(B/$B#1#6#0#0#01_!K!"6J;2867A!J>eIJ!'#3#0#0#g(B/$B#2#4#0#0#01_!K(B
$B!!!!Gr;2!J>eIJ!'#1#0#0#g(B/$B#1#2#0#0#01_$h$j!K(B
$B-(HY9H2V!"%5%U%i%s!J>eIJ!'#2#5#g(B/$B#1#9#6#0#01_!K(B

$B!V4AJ}Lt!!9b5.Lt!W(B
$B-!7'C@!J>eIJ!'#1(Bg/$B#1#2#0#0#01_$h$j!"CfIJ!'#1(Bg/$B#1#0#0#0#01_$h$j!"JBIJ!'#1(Bg$B!'#8#0#0#01_$h$j!"2 $B-"5m2+!J>eIJ!'#1(Bg/$B#1#2#0#0#01_$h$j!"CfIJ!'#1(Bg/$B#1#0#0#0#01_$h$j!"JBIJ!'#1(Bg$B!'#8#0#0#01_$h$j!"2 $B-#eIJ!'#1(Bg/$B#3#0#0#01_$h$j!"CfIJ!'#1(Bg/$B#2#5#0#01_$h$j!"JBIJ!'#1(Bg$B!'#2#0#0#01_$h$j!"2 $B-$%A%c!<%,!"%+%P%N%"%J%?%1!"%7%Y%j%"NneIJ!'#5#0#0(Bg/$B#1#5#6#0#01_$h$j!K(B
$B-%%a%7%^%3%V!J>eIJ!'#5#0#0(Bg/$B#1#2#5#0#01_$h$j!"(B
$B-&%d%^%V%7%?%1!J>eIJ!'#5#0#0#g(B/$B#1#2#5#0#01_$h$j!"(B
$B-'%"%,%j%/%9B{!J%V%i%8%k;:!K!J>eIJ!'#5#0#0(Bg/$B#5#6#0#0#01_$h$j!K(B

$B!!(B$B!!(B$B!!!VL14VLt!JLtMQ?"J*!"LtAp!"@8Lt!K!"LtMQ


$BBg;34AJ}F2Lt6I(B $B87A*@8LtD49g4AJ}Lt(B
($B@y$8Lt(B)$B$N$40FFb!!Bg;34AJ}F2Lt6I!!4AJ}=hJ}2r@b!"8zG=!&8z2L!"EjLtL\I8$H1~MQ!!(B

$B!!(B$B5HED(B $BOBED(B $B6b5o!!!V4AJ}$r@y$8$kEZIS$r%/%j%C%/$7$F$M!*!W(B

$B!!$4MhE9$N3'MM!"4AJ}Lt$GLB$o$l$?$i!"Bg;34AJ}F2Lt6I$N!V4AJ}7r9/AjCL!JD49g4AJ}Lt!a87A*@8Lt;HMQ!K!W$r!"$4MxMQ$/$@$5$$!#(B
$B!!!!!!$I$&$>!"$*5$7Z$K$*EEOC$/$@$5$$!#$*BT$ACW$7$F$*$j$^$9!#(BTel : $B#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4!JBg;34AJ}$G!"%$%4!"IT0B!"%J%7!*!K(B

$B!!4AJ}Lt$O!"FC$KK}@-2=$7$?IB5$$K$h$/8z$/(B !!!

$B!VBg;34AJ}F2(B $BFC=8(B $B:#OCBj$N4AJ}Lt(B !!! $B!W(B

$B!VBg;34AJ}F2(B $BFC=8(B: $B4AJ}$NF@0U$JIB5$(B !!! $B!W(B

$B!VBg;34AJ}F2(B $BFC=8(B: $B$3$N4AJ}Lt$,8z$/(B !!! $B!W(B

$B!V(B $B87A*(B: $B$9$08z$/$HI>H=$N4AJ}Lt(B !!! $B!W(B

$B!V(B $B87A*(B: $B$h$/8z$/$HI>H=$N4AJ}Lt(B !!! $B!W(B


$B!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B

$B!!!!!!!!!!!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I!!4AJ}7r9/AjCL!JL5NA!K!!$*?=$79~$_MQ;f!JLd?GI=!K(B

$B!VBg;34AJ}F2(B $B4AJ}0e3X$H4AJ}7r9/AjCL!W(B

$B!!(B$B!!(B

$B$40';"(B
$BBg;34AJ}F2Lt6I!JElMN0e3X@lLg!J4AJ}Lt!&o*5d!K!ao*5d<#NE< $BKL3$F;$+$i6e=#!"2-Fl8)$N?M$^$G!"F|K\A49q!"MZ$+1sJ}$+$i$N$4AjCL $B3'MM$+$i$N$4?.Mj!"K\Ev$K4r$7$/;W$$$^$9!#!!;dC#$O!"$3$N;v $B8=>u$K4E$s$:$k$3$H$J$/!"F|!9?JJb$9$kElMN0e3X!":G@hC<$N4AJ}Lt!"o*5d<#NE$r$4Ds6!$G$-$k$h$&!"5;=Q8&oS!">pJs<}=8B>!"(B
$B?4$7$F!"F|!9!"EX$a$F$*$j$^$9!#!!4AJ}Lt6IE9Fb$O69$/HQ;($G!"$4LBOG$r$*$+$1$7$F!"?=$7Lu$"$j$^$;$s$,!"(B
$B$I$&$>!"$*5$7Z$K$*F~$j$/$@$5$$!#!!$^$?!"4AJ}Lt$Ho*5d<#NE$NJ;MQ$r$*9M$($N$*5RMM!"%W%i%$%P%7!<$rFC$K5$$K$J$5$k$*5RMM!"(B
$B2HB2A40w$G$N$4AjCL$r4uK>$5$l$k$*5RMM$K$O!"$f$C$?$j$H$7$?!"o*5d<#NE< $B$I$&$>!"$4MhE9A0$K!";vA0M=Ls$r$*4j$$CW$7$^$9!#(B0283-22-1574$B!J%$%4!&IT0B!&%J%7!K(B



$BElMN0e3X!J4AJ}Lt!&o*5d!K@lLg!!Bg;34AJ}F2Lt6I!JF1o*5d<#NE<
$B8=:_!"@>MN0e3XC1FH$G$O $BElMN0e3X!J4AJ}Lt!&o*5d!K!&<+A3NEK!!&Jd40BeBXNEK!$NNO$r3hMQ$7$F8z2L$r>e$2$F$$$/!"(B
$BE}9g0eLt3X!"E}9gNEK!$N
$BBg;34AJ}F2Lt6I!JF1o*5d<#NE< $BEl@>$N1QCN!J2a5n$+$i8=Be$^$G$N0e3XLt3X0eNE>pJs!a4AJ}Lt!&o*5d$N8EE5!"@.=q!"4AJ}Er:^$N;HMQ7P83!"8=Be$NNW>27P83!"Jd40BeBXNEK!$NNW>27P83!K(B
$B$r=8$a$F!":G$bM-8z$H9M$($i$l$kElMN0e3X!J4AJ}Lt!&o*5d!K!"<+A3NEK!!"Jd40BeBXNEK!$r!"$4Ds6!$9$k$3$H$G$9!#(B

$BBg;34AJ}F2Lt6I!JF1o*5d<#NE< $B?@7PaVDK!JK}@-aVDK!&DK3P2aIR>uBV!&@~0]6ZDK>I!&?@7P>c32@-aVDK!K$dG>7l4I>c328e0d>I!"=E>I6ZL5NO>I$J$I$N?@7PJQ@-<@45!J?@7PFqIB!K!"(B
$B4X@a%j%&%^%A$d%7%'!<%0%l%s>I8u72$J$I$Ng186IB!"5$4I;YSCB)$J$I$NK}@-8F5[4o<@45!"DYag@-BgD21j$d%/%m!<%sIB!"%"%H%T!<@-HiIf1j$J$I<+8JLH1V<@45!"(B
$B?R>o@-4%a}$N45I>u$,0BDj$7$J$$J}!9!"99G/4|>c32$dITG%>I$N$h$&$J=w@-FCM-$NIB5$$J$I$N45 $B@>MN0e3XE*<#NE$@$1$G$O= $B$^$?!"9bNpI$dJb9T:$Fq!"GY1j!"Nd$(!"$7$S$l!"GSG">c32$J$IG/Np$H6&$KA}$($F$/$kIB5$$N45
$B7+$jJV$7$^$9$,!"Bg;34AJ}F2Lt6I!JF1o*5d<#NE< $B8=:_!"@>MN0e3XC1FH$G$O $BElMN0e3X!J4AJ}Lt!&o*5d!K!"<+A3NEK!!"Jd40BeBXNEK!$NNO$r3hMQ$9$kE}9g0eLt3X!"E}9gNEK!$N3NN)$rL\;X$7$F$$$^$9!#(B
$B4pK\E*$K!"$I$NMM$J<@45$N$4AjCL$b$*o$KM-8z@-$,9b$$<@45$H$"$^$j8z2L$,4|BT$G$-$J$$<@45$,$"$k$3$H$b;v $B$=$3$G!"Bg;34AJ}F2Lt6I!JF1o*5d<#NE<e$2$F$$$k<@45$r$$$/$D$+$4>R2p$7$^$9!#(B

$B-!G'CN>I!J%"%k%D%O%$%^!7l4I@-G'CN>I!"%l%S!<>.BN7?G'CN>I!"A0F,B&F,7?G'CN>I!J%T%C%/IB!K!"%Q!<%-%s%=%sIB!"$F$s$+$s!K(B
$BFC$K!"G'CN>I!"$F$s$+$s$N45I>u$N2~A1!"(BQOL$B!J@83h$Ne$K8z2L$r>e$2$F$$$^$9!#(B
$B9bNpI$G$O!"J*K:$l$NB>$K@:?@E*$KIT0BDj$K$J$k!"J*$r $B$"$k$O$:$N$J$$J*$,8+$($F61$($k!"$J$IMM!9$J0[>o$J@:?@>I>u$,H/>I$7$F45 $B$3$NMM$J45$rR2p!K$,M-8z$G$"$j$^$9!#(B
$B$^$?!"?@7PJQ@-<@45$J$I$N?@7PFqIB$N45I8u$K!"Bg;34AJ}F2Lt6I$ND49g4AJ}Lt!"(B
$B!V8bh%hPEr!"8^NjEr!"5m $BF1
$B-"G>7l4I>c32!JG>9<:I!"G>=P7l!"$/$bKl2<=P7l!K8e0d>I(B
$BFC$K!"G>7l4I>c32!JG>9<:I!"G>=P7l!"$/$bKl2<=P7l!K8e0d>I$d?@7PJQ@-<@45$KH<$&Sk2<>c32$K8z2L$r>e$2$F$$$^$9!#(B
$BG>7l4I>c32$d%Q!<%-%s%=%sIB$J$I$N?@7PJQ@-<@45!J?@7PFqIB!K$G$OJ*$,H~L#$/?)$Y$i$l$J$$!VSk2<>c32!W$,@8$8$d$9$/!"$=$l$K$h$C$FGY1j$r5/$3$7$?$j0_aq$r:n$k$3$H$,$"$j$^$9!#(B
$B$3$NMM$J452F8|KQEr9gIzNa0{2C8:J}!"B>1~MQ=hJ}!W$do*5d7PMm%D%\NEK!(B($BB@l0!"B-;0N$!"B>1~MQ7j!K$X$N;\=Q$,M-8z$G$"$j$^$9!#(B

$B-#K}@-8F5[4o<@45!J(BChronic Respiratory Disease, CRD$B!K(B
$B!aK}@-JD:I@-GY<@45(B(COPD)$BGY5$.:YK&4b!"GY@~0]>I!"K}@-6;Kl<@45!"?PGY!"GY9%;@5eA}B?>I!"GY:I@r>I!"%5%k%3%$%I!<%7%9!"?gL2L58F5[>I8u72!"(B
$BGY@-?4!"5$4I;Y3HD%>I$J$I$N5^@-A}0-$NM=KI!"K}@-8F5[4o<@45$G$O!"Iwu$,A}0-$7!"$=$N7+$jJV$7$G $B$3$NMM$J451~MQ=hJ}!W$,M-8z$G$"$j$^$9!#(B
$B$3$&$7$?45
$B-%3F $B0\M=KI!K!"4KOB%1%"!"@83h$N $B1dL?!aM\@8!J$h$&$;$$!aL?$rM\$$?-$P$9!a:G8e$^$GDL>o$N@83h$rB3$1$J$,$i!V$,$s$H6&B8!W $BJd40BeBX0eNE(B $B!J(BCAM=Complementary and Altemative Medicine$B!K$N2r@b(B

2015. 4
$B!JJ?@.#2#7G/#47n!K(B
$BBg;34AJ}F2Lt6I!JF1o*5d<#NE<
$B2,;3Bg3X0e3XGn;N!JJ,;R:YK&0e3X8&5f;\@_?@7P>pJs3X!"G>Be $BFAEgBg3XLt3X=$;N!J0eNE@8L?Lt3X!!@=Lt2=3X!!@8J*LtIJ2=3X!K(B
$BBg;3Gn9T(B
Dr. HIROYUKI OHYAMA,Ph.D.

$B!JI,MW;v9`$r!"$45-F~$N>e!"Aw?.$7$F$/$@$5$$!#!K(B

$BBg;34AJ}F2Lt6I!!Bg;3Gn9T!!4AJ}7r9/AjCL(B
$B$*?=$79~$_MQ;f(B
$B!JLd?GI=!K(B

$B!VElMN0e3X(B($B4AJ}Lt(B $Bo*5d(B)$B<+A3NEK!(B.$BJd40BeBXNEK!!W(B

$B!!!!-!G'CN>I!!!J%"%k%D%O%$%^!7l4I@-G'CN>I!"%l%S!<>.BN7?G'CN>I!"A0F,B&F,7?G'CN>I!J%T%C%/IB!K!"(B

$B!!!!-"G>7l4I>c328e0d>I!!!JG>9<:I!"G>=P7l!"$/$bKl2<=P7l!K!!(B

$B!!!!-#%Q!<%-%s%=%sIB!"$F$s$+$s!!(B

$B!!!!-$?@7P>c32@-aVDK!!(B

$B!!!!-%=E>I6ZL5NO>I!!(B

$B!!!!-&g186IB!!!J4X@a%j%&%^%A!"%7%'!<%0%l%s>I8u72!K!!(B

$B!!!!-'K}@-8F5[4o<@45!!!JK}@-JD:I@-GY<@45(B(COPD)$BGY5$I!"K}@-6;Kl<@45!"(B
$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?PGY!"GY9%;@5eA}B?>I!"GY:I@r>I!"%5%k%3%$%I!<%7%9!"?gL2L58F5[>I8u72!"GY@-?4!K!!(B

$B!!!!-(<+8JLH1V<@45!!!JDYag@-BgD21j!"%/%m!<%sIB!K!!(B$B!!(B

$B!!!!-)%"%H%T!<@-HiIf1j!!(B

$B!!!!-*=w@-FCM-$NIB5$!!!J99G/4|>c32!";R5\FbKl1j!";R5\6ZI!K!!(B

$B!!!!-+$*G/4s$j$NIB5$!!!JJb9T:$Fq!"JQ7A@-4X@a>I!"9|AFr">I!"GY1j!"Nd$(!"$7$S$l!"GSG">c32!"GrFb>c!"NPFb>c(B
$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!"K}@-?UITA4!"69?4>I!"K}@-?4ITA4!"4N9EJQ!"C@@P!"C@$N$&1j!"D2JD:I!"0_$,$s!"BgD2$,$s!K!!(B

$B!!!!(B$B!!(B$BBg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B


$B!!!!FC=8!'%9%H%l%9$H?4$N2J3X(B

$B!!(B$B!!(B

$BBg;34AJ}F2Lt6IImB0Bg;3=!GlElMN0e3X5-G04[ITG%<#NE@lLgo*5d<#NE<<(B $B40A4M=Ls@)(B 0283-22-1607

$B4AJ}$r8=BeIB$K3h$+$9!*4AJ}@lLg$NBg;34AJ}F2Lt6I(B
$B4AJ}2r@b!!4AJ}Lt$N:^7A$K$D$$$F(B

$B-!@y$8Lt!'#1F|J,$N@8Lt$r#4#0!A#6#0J,@y$8$FI~MQ$9$k$b$N(B
$B-"%(%-%9:^!'@y$8$?$b$N$rG;=L$7!"Ij7A:^$rF~$lpyN3!">{:^Ey$H$7$?$b$N(B
$B-#86Kv;6:^!'@8LtJ4Kv$r:.OB$7$?$b$N(B
$B-$4]:^!'@8LtJ4Kv$r:.OB$7!"K*L*!&$G$s$W$s$J$I$GN}$C$F5e7A$K$7$?$b$N(B

$BBg;34AJ}F2Lt6I!!87A*!!4AJ}4]:^$O!"MM!9$JMxE@$r;}$D4AJ}Lt$G$9(B

$B-!J4Kv$=$N$^$^8G$a$?$b$N$G$9$N$G!"2CG.$9$k$3$H$G4xH/$7$F$7$^$&@:L}!"(B
$B?e$KMO$1$K$/$$@.J,!"G.$GJ,2r$7$F$7$^$&@.J,$J$I!"7A$NDL$j!"4]$4$HMxMQ$G$-$^$9!#(B
$B-"L#!&=-$$$,$7$K$/$$$?$a!"@y$8Lt$d%(%-%9:^$,0{$a$J$$?M$K$b$4MxMQ$$$?$@$1$^$9!#(B
$B-#=y!9$K$H$1$k$?$a!"$f$C$/$j!"2:$d$+$K8z$-$^$9!#(B
$B-$$5$i$K!"@y$8Lt$d%(%-%9:^$KHf$Y!"#1F|$N@8Lt$N;HMQNL$,>/$J$/!"(B
$B@8Lt$rL5BL$J$/;H$($k4D6-$KM%$7$$:^7A$G$9!#(B

$B4AJ}@lLg!!Bg;34AJ}F2Lt6I!!87A*!!4AJ}4]:^!!0lMw(B

$B-!6n1w7l4]!"-"Em3K>55$4]!"-#7K;^h*Nj4]!"-$7KNj2CBg2+4]!"-%M}Cf4]!"-&4%U*?M;2H>2F4]!"(B
$B-';02+4]!"-(2+O"2rFG4]!"-)2+2r4]2CBg2+!"-*Bg4E4]!"-+Kc;R?N4]!"-,H,L#4]!"--O;L#4](B





$B8M8e4|(B



$B8MKv4|!JKkKv!K(B

$B$40';"!'(B
$BBg;34AJ}F2Lt6I!JElMN0e3X@lLg!J4AJ}Lt!&o*5d!K!ao*5d<#NE< $BKL3$F;$+$i6e=#!"2-Fl8)$N?M$^$G!"F|K\A49q!"MZ$+1sJ}$+$i$N$4AjCL $B3'MM$+$i$N$4?.Mj!"K\Ev$K$"$j$,$?$/;W$$$^$9!#!!;dC#$O!"$3$N;v $B8=>u$K4E$s$:$k$3$H$J$/!"F|!9?JJb$9$kElMN0e3X!":G@hC<$N4AJ}Lt!"o*5d<#NE$r$4Ds6!$G$-$k$h$&!"5;=Q8&oS!">pJs<}=8B>!"(B
$B?4$7$F!"F|!9!"@:0lGU$NEXNO$rCW$7$F$*$j$^$9!#!!4AJ}Lt6IE9Fb$O69$/HQ;($G!"$4LBOG$r$*$+$1$7$F!"?=$7Lu$"$j$^$;$s$,!"(B
$B$I$&$>!"$*5$7Z$K$*F~$j$/$@$5$$!#!!$^$?!"4AJ}Lt$Ho*5d<#NE$NJ;MQ$r$*9M$($N$*5RMM!"%W%i%$%P%7!<$rFC$K5$$K$J$5$k$*5RMM!"(B
$B$42HB2A40w$G$NAjCL$r4uK>$5$l$k$*5RMM$K$O!"$f$C$?$j$H$7$?!"o*5d<#NE< $B$I$&$>!"$4MhE9A0$K!";vA0M=Ls$r$*4j$$CW$7$^$9!#(B0283-22-1574$B!J%$%4!&IT0B!&%J%7!K(B

$B!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B

$B!!!!!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I!!4AJ}7r9/AjCL!JL5NA!K!!$*?=$79~$_MQ;f!JLd?GI=!K(B




$B!VBg;34AJ}F2(B $BFC=8(B $B<+A3Lt$r9M$($k(B !!! $B!W(B

$B!!!!!!!!(B$B!!!V9b5.Lt!W0lMw(B

$B!!!!!!!!(B$B!!5m2+!J%4%*%&!K!"sM9a!J%8%c%3%&!K!"7'C@!J%f%&%?%s!K!"j9nH(B($B%;%s%=(B)$B!"f9MS3Q!J%l%$%h%&%+%/!K!"
$B!!!!!!!!(B$B!!Nn
$B!!!!!!!!(B$B!!3$N6!J%+%$%j%e%&!K!"3$GO!J%+%$%P!K!"3$6i?U!J%+%$%/%8%s!K!"
$B!!!!!!!!(B$B!!BgFC=8!'E_Cn2FAp(B($B$H$&$A$e$&$+$=$&!K$H$O!)!*4Z9q%I%i%^(B $B!V5\Dn=w41%A%c%s%0%`$N@@$$!W$G$b>R2p$5$l$?HkLt!)(B

$B!!!!!!!!(B$B!!BgFC=8!'!V(B $B

$B!!!!!!!!!!(B$B!!FC=8!'5m2+!J$4$*$&!K!"
$B!!!!!!!!!!(B$B!!FC=8!'
$B!!!!!!!!(B$B!!FC=8!'CON5!J$8$j$e$&!K(B Lumbricus$B!!!VCON5$NNW>21~MQ$r9M$($k!W!!-!E|G"IB!"-"K}@-4X@a%j%&%^%A(B

$B!!!!!!!!!!(B$B!!FC=8!'5m2+!J%4%*%&!K!aO;?@4]!J$m$/$7$s$,$s!K!"5m2+@:?44]!J$4$*$&$;$$$7$s$,$s!K!"?M;25m2+;6!J$K$s$8$s$4$*$&$5$s!K(B

$B!!!!!!!!(B$B!!FC=8!'5m2+@6?44]!J$4$*$&$;$$$7$s$,$s!K!!NnG-9a!J%7%Y%C%H!K$H$O!)(B

$B!!!!!!!!!!(B$B!!FC=8!'ED<7?M;2$H$O!"-!!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!!!!!(B$B!!FC=8!'Nn$B!!(B

$B!!!!!!!!!!(B$B!!;I8^2C!J$7$4$+!K$H$O!)!!#N#A#S#A$bCmL\$7$?Lt8z!*!*!*(B

$B!!!!!!!!(B$B!!FC=8!'?M;2!J$K$s$8$s!K$H$O!"(B

$B!!!!!!!!(B$B!!FC=8!';0<7?M;2!"ED<7?M;2!"ED;0<7?M;2$H$O!"-"(B

$B!!!!!!!!(B$B!!FC=8!'Im;R!J$V$7!K$H$O!)(B

$B!!!!!!!!!!(B$B!!FC=8!'C0;2!J$?$s$8$s!K$H$O!)!!@8Lt!VC0;2!J$?$s$8$s!K$NLtM}:nMQ$K$D$$$F(B

$B!!!!!!!!!!(B$B!!6Z9|Ap!J$-$s$3$D$=$&!K$H$O!)(B

$B!!!!!!!!!!(B$B!!FC=8!'LtAp$N8zG=!&8z2L(B


$B!VFC=8(B $BITO7D9

$B!!!!!!!!!!(B$B!!`{6L9Q!V%1%$%.%g%/!W$H$O!)!!(B*$BNr;KE*0e=q(B (I"$BEl0eJu4U(I#(B $B$N:G=i$K5-:\$5$l$F$$$k:G=EMW=hJ}$H$O!)(B

$B!!!!!!!!!!(B$B!!ITO7D9

$B!!!!!!!!!!(B$B!!BNCf$N7l9T$r$h$/$7@83h=,47IB$rJQ$($k!X(B $B`{6L9Q!J$1$$$.$g$/$3$&!K!Y$NHkL)(B

$B!!!!!!!!!!(B$B!!HkLt!"!V`{6L9Q!J$1$$$.$g$/$3$&!K!W$NFf$KGw$k!*(B

$B!!!!!!!!!!(B$B!!FC=8!'54J?$H`{6L9Q!J$1$$$.$g$/$3$&!K!!!V54J?!aD9C+@nJ?B"30EA!W(B

$B!!!!!!!!!!(B$B!!CO2+!J%8%*%&!K$N8zG=$K$D$$$F(B

$B!!!!!!!!!!(B$B!!%(%>%&%3%.$H$O!)!!8^2C;2(B

$B!!!!!!!!!!(B$B!!FC=8!'!V?U5u!J$8$s$-$g!K!W$H$O!)(B

$B!!!!!!!!!!(B$B!!IO7l$K8z$/4AJ}Lt!*(B

$B!!!!!!!!(B$B!!%H%T%C%/%9(B $B!V(B $B4AJ}Lt$G7l1U%5%i%5%i!*!W(B $B!v!V4'?4#29fJ}!W$H$$$&4AJ}Lt$r$4B8CN$G$9$+!)(B

$B!!!!(B $B!!!!!!(B $B!!!!!VG>9<:I!"G>=P7l!"?46Z9<:I!"69?4>I!"F0L.9E2=>I$N4AJ}AjCL(B $B!W!!H/IB!":FH/$rM=KI$9$kElMN0e3X(B

$B!!!!!!!!!!!!!!!!Bg;3Gn9T@h@8!"4XEl1w7l8&5f2q!"=w@-$N7r9/!!!V$J$$$7$g$NOC!W!!Bh#82s7G:\5-;v(B

$B!!!!!!!!!!(B$B!!7l1U$K:nMQ$9$kJ*
$B!!!!!!!!!!(B$B!!=w@-$N@;Lt!*!V%5%U%i%s!W(B $B$N8z2L$H$O!"(B

$B!!!!!!!!!!(B$B!!FC=8!'?@7PDK$K8z$/4AJ}Lt!J?@7PDK!":B9|?@7PDK!"4X@a1j!"%j%e!<%^%A!K(B

$B!!!!!!!!(B$B!!D65iM[?@pyN3!J$h$&$8$s$+$j$e$&!K$HD65iW"A5pyN3!J$3$&$<$s$+$j$e$&!K$H$O!"(B

$B!!!!!!!!!!(B$B!!5H>MAINnW"!J$-$C$7$g$&$=$l$$$3$&!K$H$O!*(B

$B!!!!!!!!(B$B!!ED<7!J$G$s$7$A!K!"%3%(%s%6%$%`#Q#1#0!"%3%l%9%F%V%m%C%/!J(BCSPHP$B!K$H$O!"(B

$B!!!!!!!!(B$B!!FC=8!'%3%l%9%F%m!<%kCM$,9b$a$NJ}$KO/Js!*BgF&$+$i@8$^$l$?(B $B#C#S#P#H#P(B $B$N6C$/$Y$-8z2L(B

$B!!!!!!!!!!(B$B!!FC=8!'3h@-;@AG!J%U%j!<%i%8%+%k!K$H$O!)(B

$B!!!!!!!!!!(B$B!!FC=8!'3h@-;@AG!J%U%j!<%i%8%+%k!K$,4X$o$kBeI=E*<@45(B

$B!!!!!!!!!!(B$B!!FC=8!'3h@-;@AG=|5n:^!J%i%8%+%k%9%+%Y%s%8%c!
$B!!!!!!!!!!(B$B!!FC=8!'3h@-;@AG$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!%7%_!"%=%P%+%9$KBP$9$k4AJ}Lt(B

$B!!!!!!!!!!(B$B!!!VG"O)46@w>I!W$H4AJ}Lt(B

$B!!!!!!!!!!(B$B!!FC=8!'G"O)7k@P$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'g/fy1j$N4AJ}<#NE!!!JGSG":$Fq!"GSG"DK!";DG"46!"IQG"!"$`$/$_!"G"$NBy$j$K8z$/4AJ}Lt!K(B

$B!!!!!!!!!!(B$B!!FC=8!'E|G"IB$H%a%?%\%j%C%/%7%s%I%m!<%`!J2+O"CO2+Er$N7lE|CM!"G";@CM2~A1:nMQ$N8!>Z!K(B

$B!!!!!!!!!!(B$B!!FC=8!'FbB!;iKC$H%a%?%\%j%C%/%7%s%I%m!<%`!J6eL#H>2FEr2C8:J}$NHnK~2~A1M-8z@-$r8!>Z!K(B

$B!!!!!!!!!!(B$B!!%K%-%S$K8z$/4AJ}Lt(B

$B!!!!!!!!!!(B$B!!FC=8!'G";@CM$N9b$$?M!J9bG";@7l>I!"DKIw$N?M!K$H4AJ}Lt(B

$B!!!!!!!!!!!!(B$B!!Bg;3=!GlElMN0e3X5-G04[(B

$B!!!!!!!!!!(B$B!!FC=8!'E|G"IB$K8z$/4AJ}Lt(B$B!!9V5A!'E|G"IB$H4AJ}Lt!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!!!!!!!(B$B!!FC=8!'%3%l%9%F%m!<%k$r9M$($k!!!V9b;i7l>I$HElMN0e3X!J4AJ}Lt!&o*5d!K!W!!!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!!!!!!!(B$B!!FC=8!'%a%K%(!<%kIB$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'<*LD$j$K8z$/4AJ}Lt(B

$B!!!!!!!!!!(B$B!!FC=8!'L\$N7r9/$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'%"%l%k%.!<@-I!1j(B,$BC_G?>I!"I!?e!"I!$E$^$j$K8z$/4AJ}Lt(B

$B!!!!!!!!!!(B$B!!FC=8!'2VJ4>I!"%"%l%k%.!<@-I!1j$K8z$/4AJ}Lt(B

$B!!!!!!!!!!(B$B!!FC=8!'5$4I;YSCB)$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'?gL2>c32$HElMN0e3X!J4AJ}Lt!&o*5d!K!"ITL2>I$K8z$/4AJ}Lt!"o*5d(B

$B!!!!!!!!!!(B$B!!FC=8!'Dc7l05$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!IO7l$K8z$/4AJ}Lt!*!!FC=8!'IO7l$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!L#3P0[>o!&=-3P0[>o$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!@8LtFp9Q:^!!Cf2+9Q!J%$%\<&(B $B@Z$l<&(B $B<&$m$&(B $BC&fj(B $BaVDK(B $B$+$f$_(B $B=P7l(B $B$*$G$-(B $BF};y$/$5(B $B<>?>(B $B$H$S$R(B $BH)9S$l(B $BF|>F$1!K(B

$B!!!!!!!!!!(B$B!!@8LtFp9Q:^!!;g:,!";g1@9Q!J$R$S(B $B$"$+$.$l(B $B$7$b$d$1(B $B5{$NL\(B $B$"$;$b(B $B$?$@$l(B $B30=}(B $B2P=}(B $B<&3K(B $BfjLgNv=}(B $B$+$V$l!K(B

$B!!!!!!!!!!(B$B!!FC=8!'%"%H%T!<@-HiIf1j$HElMN0e3X!J4AJ}Lt!&o*5d!K%"%H%T!<$NHiIf>I>u$HaZ$_$K$h$$4AJ}Lt(B

$B!!!!!!!!!!(B$B!!FC=8!'%/%m!<%sIB$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!@83h=,47IB$rH<$&HnK~$KE,$7$?4AJ}Lt(B

$B!!!!!!!!!!(B$B!!!VHnK~>I!JAi$;!K$K8z$/4AJ}Lt!W!J3l?';iKCAH?%(BBAT$B$r3h@-2=$5$;M>J,$J;iKC$rJ,2r$9$k!K$H$O!"(B

$B!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I$N!VHnK~>I!JAi$;!K$K8z$/4AJ}Lt!W$,!"(B
$B!!!!!!!!!!!!!!!!!!!!J?@.#1#5G/#67n#8F|$K:4Ln;TL1?7J9!JFIGd?7J9@^9~!K$K>R2p$5$l$^$7$?!*(B
$B!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I$N!V7l1U$5$i$5$i4AJ}Lt!JF0L.9E2=$NM=KI!K!W$,!"(B
$B!!!!!!!!!!!!!!!!!!!!J?@.#1#6G/#67n#2#7F|$K:4Ln;TL1?7J9!JFIGd?7J9@^9~!K$K>R2p$5$l$^$7$?!*(B


$B!!!!!!!!(B$B!!!VK}@-aVDK!&DK3P2aIR>uBV!&@~0]6ZDK>I!W$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!(B$B!!FC=8!'@~0]6ZDK>I!J$;$s$$$-$s$D$&$7$g$&!K$H4AJ}Lt(B

$B!!!!!!!!(B$B!!FC=8!'K}@-4X@a%j%&%^%A!J(BRA$B!K$H4AJ}Lt(B

$B!!!!!!!!(B$B!!FC=8!'?M9)F)@O$H9gJ;>I!J?M9)F)@O$N45
$B!!!!!!!!(B$B!!!V4c@:HhO+!&%I%i%$%"%$!W$H4AJ}Lt(B

$B!!!!!!!!(B$B!!FC=8!'JXHk$H4AJ}Lt!!(B- $B7r9/$N%P%m%a!<%?!
$B!!!!!!!!(B$B!!!VDYag@-BgD21j!W$H4AJ}Lt(B

$B!!!!!!!!(B$B!!!V?R>o@-4%a}!W$H4AJ}Lt(B

$B!!!!!!!!(B$B!!!V%"%H%T!<@-HiIf1j!W$H4AJ}Lt(B

$B!!!!!!!!(B$B!!!V4NB!IB!J;iKC4N!&#C7?4N1j!&4N9EJQ!&4NB!4b!K!W$H4AJ}Lt(B

$B!!!!!!!!(B$B!!!VE|G"IB!&g9B!1j!W$H4AJ}Lt!!9V5A!'E|G"IB$H4AJ}Lt(B $B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!!!!!(B$B!!!VF0L.9E2=!&9b7l05!W$H4AJ}Lt!J(B $BFC=8!'%3%l%9%F%m!<%k$r9M$($k!*!K!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!!!!!(B$B!!FC=8!'9b7l05$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!(B$B!!!VK}@-?U1j!&?UITA4!W$H4AJ}Lt!!(B

$B!!!!!!!!!!!!(B*$B#g#f#r!J;e5eBN_I2aNL!K$H$O!)!!(B*CCr$B!J(BCreatinine Clearance$B!K%/%l%"%A%K%s!&%/%j%"%i%s%9(B $B$H$O!)(B

$B!!!!!!!!(B$B!!!V;R5\6Z
$B!!!!!!!!(B$B!!!V$,$s!J0-@-?7@8J*!K!W$N4AJ}AjCL!!(B- $B4b$r9M$($k(B -


$B!!!!!!(B$B!!?4$N7r9/AjCL!JElMN0e3X$HNW>2?4M}3X!K!"%9%T%j%A%e%"%k!&%1%"!c32(B

$B!!!!!!!!!!(B$B!!%Z%C%H$rK4$/$7$?;~$NHa$7$_$K8z$/4AJ}Lt!*!!FC=8!'Ha$7$_!"=}?4$K$h$$ElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'?gL2>c32!aITL2>I!"IT0B46!"7rK:>I$K8z$/ElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!?<9o$JG:$_$4AjCL$/$@$5$$!!-!$*$J$i$,=-$$!!-"H1$NLS$,Gv$$!JH4$1LS!"1_7AC&LS>I!K!!-#8}=-$,5$$K$J$k!!-$BN=-$,5$$K$J$k(B

$B!!!!FC=8!'4AJ}Lt$GBNFb>t2=!*D2Fb%U%m!<%i$,Mp$l$F$$$k$H!"-!8}=-$dBN=-$J$I!"BN$,$K$*$C$F$/$k!"0-6L6]$K$h$jD2Fb$G?)$YJ*$,IeGT$9$k$H!"(B
$B!!!!$K$*$$$N$-$D$$M-32@.J,$rH/@8!#$3$l$i$N$K$*$$@.J,$O!"JX$N$K$*$$$K1F6A$9$k$@$1$G$J$/!"7l1U$K5[<}$5$lBN=-$N860x$K$b$J$k!#(B$B!!(B

$B!!!!!!!!!!(B$B!!FC=8!'#3#0Bf$N=w@-$NG:$_!aGrH1!"$7$_!"$=$P$+$9!">.$8$o!"IX?M2J$NG:$_$K8z$/ElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'7ZEYH/C#>c32!"<+JD>I!"#L#D!"#A#D#H#D!"%"%9%Z%k%,!<>I8u72$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!(B $B4AJ}@lLg(B $BBg;34AJ}F2Lt6I!!(BQ & A$B!!=8(B

$B!!!!!!!!!!(B$B!!$J$k$[$I$J$C$H$/4AJ}Lt(B $B!J<+A3$H7r9/$r2J3X$9$k%D%`%iDs6!(B $B!K(B

$B!!!!!!!!!!(B$B!!FC=8!'@5>o$JNW>28!::CM0lMwI=!!!J7l1U@82=3X8!::!"G"8!::!"4NB!!&g9B!5!G=8!::!"E|G"IB8!::!K(B

$B!!!!!!!!!!!!!!!!!!!!!!!!9V5A!'NW>28!::!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!!!!!!!(B$B!!Bg;3=!Gl!!!V(B $BElMN0e3X5-G04[(B $B!W!!:G?7$N4AJ}0e3X!!(B
$B!!!!!!(B' sohhaku OHYAMA ' memorial, Oriental Medicine Research Museum.

$B!!!!!!(B $B!!!V!!M\@8!J$h$&$;$$!K$NF;!!!a!!<+A3$r


$B!!!!!!!!!V!!0e?4J}4,#2#2!!G%?1L.?^!!!a!!Bg;3=!GlB"=q!!0e?4J}#1#0#0#0G/$N$"$f$_$h$j!!!W(B

$B!!1J4Q#2G/!J#9#8#4!K$KC0GH9/Mj$,KP?J$7$?!"$o$,9q!"8=B8:G8E$N0e=q!V0e?4J}!W#3#04,$N$&$A!"(B
$B!!Bh#2#24,(B $B!VIX?MG%?1JT!W(B $B!VG%?1L.?^!W(B $BG%?13F7n$NG%IX$HB[;y$N;Q$J$i$S$K!"o*5d$N7P7j$,IA$+$l$F$$$k!#(B
$B!!$D$^$j!"Nr;KE*$K8+$F$b!"ElMN0e3X$OITG%<#NE$N%N%&%O%&$NJu8K$G$"$k!#!!Bg;3=!Gl(B


$B!VBg;34AJ}F2(B $BFC=8(B $B%\%1(B.$BCTJr$r9M$($k(B !!! $B!W(B

$B!!!!!!!!!!(B$B!!FC=8!'G'CN>I$HM^4N;6!J$h$/$+$s$5$s!K(B

$B!!!!!!(B$B!!FC=8!'G'CN>I$HElMN0e3X!J4AJ}Lt!"o*5d!K!!(B$B!!(B$B!!(B

$B!!!!!!!!!!(B-$B:G?72J3X$GZ$5$l$k8=Be$N4AJ}Lt(B- $B2,;3Bg3X(B $B0e3XGn;N(B $BBg;3Gn9T(B
$B!!!!!!(B$B!!%\%1!JG'CN>I!"%"%k%D%O%$%^!
$B!!!!!!!!!!(B$B!!4AJ}Lt!"!V2CL#29C@Er!J$+$_$&$s$?$s$H$&!K!W$,!"%"%k%D%O%$%^!
$B!!!!!!!!!!(B$B!!FC=8!'G'CN>I$HElMN0e3X!J4AJ}Lt!&o*5d!K!a%"%k%D%O%$%^!<7?!"G>7l4I@-!"%l%S!<>.BN7?!"%T%C%/IB!"8&5f:GA0@~(B

$B!!!!!!!!!!(B$B!!FC=8!'%l%S!<>.BN7?G'CN>I!J(Bdementia with Lewy bodies$B!a(BDLB$B!K$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!FC=8!'%Q!<%-%s%=%sIB$HElMN0e3X!J4AJ}Lt!&o*5d!K(B

$B!!!!!!!!!!(B$B!!%"%k%D%O%$%^!<7?O7G/G'CN>I$KBP$9$k!V%d%^%V%7%?%1;R28z2L!!BgM'1Q0l!"@6?eDLN4!">.>>Lw90(B

$B!!(B$B!VElMN0e3X%\%1!JG'CN>I!aCTJr>I!K$NAjCL!W$*?=$79~$_%U%)!<%`(B $B!!(B $BG'CN>I!aCTJr>I$NAjCL(B

$B!V%"%k%D%O%$%^!7l4I@-CTJr(B($BG>9<:I(B.$BG>=P7l(B)$B!W(B

$B!!!!!!!!!!!!!!%\%1$:$K#1#0#0:P$^$G@8$-$k$?$a$K!"2,;3Bg3X!!0e3XGn;N!!Bg;3Gn9T(B

$B!!!!!!!V!!CTJr>I!JG'CN>I!"%\%1!K!&%"%k%D%O%$%^!<$O$b$&I]$/$J$$!*!!%\%1$NG:$_(B $BAjCLAk8}!!!W!!(B
$B!!!!!!!!!!!!!!!!!!!!!!>o;~
$B!!!!(B $B!!!!!!!!(B $B!!(B$BI=;f(B$B!!(B$BI=;f(B$B!!(B$BI=;f(B

$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!Bg;3Gn9TCx:n(B

$B!!!!!!!!!!Bg%Y%9%H%;%i!$r


$B!V(B $BFC=8(B $B%Z%C%H$N7r9/$H?)$r9M$($k(B !!! $B!W(B

$B8$!"G-!"$&$5$.!"%U%'%l%C%H$b?M4V$HF1$8S.F}N`$G$9!#?M$,$+$+$kIB5$$N$[$H$s$I$O%Z%C%H$b$+$+$j$^$9!#(B
$B$G$9$+$i!"Ls#2#0#0#0G/$N1QCN$+$i@8$^$l$?ElMN0e3X$O!"8$!"G-!"$&$5$.!"%U%'%l%C%HB>!"F0J*$K$b$H$F$b8z2L$,$"$j$^$9!#(B

$B!!(B$B!!!V(B $B%Z%C%H4AJ}AjCL<.>>Lw90@h@8!J=C0e;U!K(B

$B!!!!!!0e3XGn;N(B $B>.>>Lw90@h@8!!!V4AJ}Lt$N=C0e2JNN0h$K$*$1$k3hMQ$K$D$$$F!W(B

$B!V%Z%C%H4AJ}AjCL<$B!!(B

$B!!(B* $B%Z%C%H$,4n$V!"ElMN0e3X!J4AJ}Lt!"o*5d!"$"$s$^!&%^%C%5!<%8!&;X05!K!"2HDm$G$G$-$k%Z%C%H$N$?$a$NElMN0e3X7r9/K!Bg8x3+(B !!!$B!!(B
$B!!!!!!!V$U$l$k$@$1$G%Z%C%H$,4n$S855$$K$J$kElMN0e3X$NHkK!!W(B $B0e3XGn;NBg;3Gn9TCx:n!"0e3XGn;N>.>>Lw904F=$(B $B!J<9I.Cf!K(B

$B!V%Z%C%H4AJ}AjCL$NB?$$IB5$!W(B
$B$,$s!"?UB!IB!"?4B!IB!"4NB!IB!"E|G"IB!"$F$s$+$s!"D21j!"30<*1j!"HiIf1j!"7kKl1j!"DG4VHD%X%k%K%"!"5$4I;Y1j!"0_D21j(B

$B!V8$%Z%C%H4AJ}AjCL$NB?$$8$ $B-!%H%$!&%W!<%I%k-"%A%o%o-#%_%C%/%9(B*$B-$%_%K%A%e%"!&%@%C%/%9%U%s%I-% $B-(%_%K%A%e%"%7%e%J%&%6!<-)%7!
$B!VG-%Z%C%H4AJ}AjCL$NB?$$G- $B-!%9%3%F%#%C%7%e%U%)!<%k%I-"%"%S%7%K%"%s-#%"%a%j%+%s%7%g!<%H%X%"-$%"%i%0%I!<%k-%%m%7%"%s%V%k!<-&%^%k%A%+%s(B
$B-'%=%^%j-(%N%k%&%'%8%c%s%U%)%l%9%H%-%c%C%H-)%a%$%s%/%$!<%s-*%7%c%k%H%j%e!<(B

$B!!(B$B!!!!!!(B

$B!V8$%Z%C%H4AJ}AjCL$NB?$$IB5$!W!!$,$s!"?4B!IB!"?UB!IB!"4NB!IB!"D21j!"$F$s$+$s!"E|G"IB!"0_3HD%!"0_G1E>!"%/%C%7%s%0IB!"LH1V<@45!"LH1V0[>o(B

$B!VG-%Z%C%H4AJ}AjCL$NB?$$IB5$!W!!$,$s!"%M%3EA@w@-J"Kl1j!"G-%(%$%:!"G-Gr7lIB!"9C>uA#5!G=P6?J>I!"4N1j!"4N9EJQ!"%&%$%k%9@-8F5[4o46@w>I(B

$BFCJL4AJ}AjCL!'%Z%C%H!J8$!"G-!"$&$5$.!"%U%'%l%C%H$J$I!K$N$,$s4b!"?4B!IB!"$F$s$+$s!"Hn$j$9$.!"%\%1!"ITG%!"%"%l%k%.!<$NG:$_(B

$B!!FC=8!'%Z%C%H$r855$$KD9@8$-$5$;$k4AJ}Lt!"D9R2p(B


$B!!!!!!!!!!!!!!(B$B5HED(B $BOBED(B $B6b5o!!!!!V(B $B$4MhE9$N3'MM!"$I$&$>!"$h$m$7$/$*4j$$CW$7$^$9!*!W(B


$B!VBg;34AJ}F2Lt6I(B $B87A*>&IJ!WFCJL3d0z%;!<%kBP>]>&IJ(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!JCm0U!KBg;34AJ}F2Lt6I$NDL>o2A3J$O!"%a!<%+!<4uK>>.Gd2A3J$G$9!#(B

$B87A*4AJ}Lt!J0lHLMQ0eLtIJ!'Bh#2N`!"Bh#3N`!K(B
$B!!#1!K%&%A%@5mN62+(B$B!!#2!K%&%A%@@8Lt@=:^Fs9fJ}(B$B!!#3!K?.=#LtIJ8&5f=j(B $B%Q%J%C%/%9!&%1%$%.%g%/!J`{6L9Q!K(B$B!!#4!K!V5m2&4]!W(B
$B!!#5!K1@C@%(%-%9pyN3!J2CL#29C@Er!K(B$B!!#6!KO;?@4](B$B!!#7(B) $BY(s'!J$X$s$;$-!K(B$B!!#8(B) $B%;%s%J%@%$%*%&>{(B
$B!!#9(B) $B0UH/!J$$$O$D!K%(%-%9pyN3(B$B!!(B10) $B0RFA!J$$$H$/!K(B$B!!(B11) $B4N@8!J$+$s$;$$!K(B$B!!(B12$B!K87A*%^%D%&%i0lHLMQ4AJ}%(%-%9:YN3(B
$B!!(B13) $B87A*%D%`%i0lHLMQ4AJ}%(%-%9@=:^(B$B!!(B15) $B%^%D%&%i5]5"D47l0{Bh0l2C8:!J$-$e$&$-$A$g$&$1$D$$$s$@$$$$$A$+$2$s!K(B
$B!!(B16$B!K(B $BAI=a!J$=$8$e$s!K(B$B!!(B17$B!K6A@$B!!(B18$B!K6nIw2rFG;6!J$/$U$&$2$I$/$5$s!K%(%-%9:YN3!!(B
$B!!(B19$B!KI!NE!J$S$j$g$&!K(B$B!!(B20) $BAP;2!J$=$&$8$s!K(B$B!!(B22) $BFbI~MQ%Q%W%i!<%k(B $B!!(B23) $B5m2+@6?44]!J$4$*$&$;$$$7$s$,$s!K(B
$B!!(B24$B!K(BJPS $B[95FCO2+4]!J$3$.$/$8$*$&$,$s!K(B$B!!(B25$B!K(BJPS $BCNGpCO2+4]!J$A$P$/$8$*$&$,$s!K(B$B!!(B26$B!K0B?@Jd?44]!J$"$s$7$s$[$7$s$,$s!K(B
$B!!(B27$B!K<*LD4]!J$8$a$$$,$s!K(B$B!!(B28$B!K[95FCO2+4]!J$3$.$/$8$*$&$,$s!K(B$B!!(B29$B!K5_@:!J$-$e$&$;$$!K(B$B!!(B30$B!K%o%s%]%i%C%/$*$s(B
$B!!(B31$B!K?4N6!J$7$s$j$e$&!K(B$B!!(B32$B!K6dfK2rFG;6!J$.$s$.$g$&$2$I$/$5$s!K(B$B!!(B33$B!K6dfK2rFG4]!J$.$s$.$g$&$2$I$/$,$s!K(B
$B!!(B34$B!KDKMm4]!J$D$&$i$/$,$s!K(B$B!!(B35$B!K$B!!(B36$B!K@8L.Ju!J$7$g$&$_$c$/$[$&!K(B
$B!!(B37$B!K>.7zCfEr%A%e%"%V%k!J$7$g$&$1$s$A$e$&$H$&$A$e$"$V$k!K(B$B!!(B38$B!K;g:,!J$7$3$s!K#5#0#0#g(B $B!!(B39$B!K%R%]%l%9(B $B!!(B
$B!!(B40$B!K8^J*2rFGEr!J$4$b$D$2$I$/$H$&!K(B$B!!(B41$B!K6n1w7l4]!J$/$*$1$D$,$s!K(B$B!!(B42$B!K7K;^h*Nj4]!J$1$$$7$V$/$j$g$&$,$s!K(B
$B!!(B43$B!K2+O"2rFG4]!J$*$&$l$s$2$I$/$,$s!K(B$B!!(B44$B!KGrK2C0!J$O$/$[$&$?$s!K(B$B!!(B45$B!K%3%U%m%s%(!<%9(B$B!!(B46$B!K5m2+=cKv!J%4%*%&!K(B
$B!!(B47$B!K2s=U@g!J$+$$$7$e$s$;$s!K(B $B!!(B48$B!K2wD2F|OB!J$+$$$A$g$&$S$h$j!K(B$B!!(B49$B!K2wI!9Q!J$+$$$S$3$&!K(B$B!!(B50$B!KO;?@4]!J$m$/$7$s$,$s!K(B
$B!!(B51$B!K?M;25m2+;6!J$K$s$8$s$4$*$&$5$s!K(B$B!!(B$B!!(B52$B!K;2B{1I1R4]!J$8$s$8$g$&$($$$($$$,$s!K(B$B!!(B53$B!K;g1@9Q:A:^(BM$B!J$7$&$s$3$&$6$6$$!K(B
$B!!(B54$B!K8qC@G[9g0_D2Lt7K8q4]!J$1$$$j$,$s!K(B$B!!(B55$B!K%i%j%"%s>{(B $B!!(B56$B!K3+K-(B $B`{6L9Q!JFJK\E73$F2!K(B$B!!(B$B!!(B$B!!(B57$B!K$+$C$3$&$7$g$&$-$5$s(B
$B!!(B58$B!K@i6bFbBq;6!J$;$s$-$s$J$$$?$/$5$s!K(B$B!!(B59$B!K[95FCO2+4]%(%-%9pyN3(BG$B!J$3$.$/$8$*$&$,$s!K(B $B!!(B60$B!KO"
$B!!(B61$B!KBg7zCfEr!J$@$$$1$s$A$e$&$H$&!K(B $B!!(B62$B!K<"?UL@L\Er!J$8$8$s$a$$$b$/$H$&!K(B $B!!(B63$B!K<"?UDL<*Er!J$8$8$s$D$&$8$H$&!K(B
$B!!(B64$B!KFH3h4s@84]!J$I$C$+$D$-$;$$$,$s!K(B $B!!(B63$B!K4D85@67l0{!J$+$s$2$s$;$$$1$D$$$s!K(B$B!!(B64$B!K7K;^<[LtCNJlEr!J$1$$$7$7$c$/$d$/$A$b$H$&!K(B
$B!!(B65$B!K@6?4O!;R0{!J$;$$$7$s$l$s$7$$$s!K(B $B!!(B66$B!K?I0P@6GYEr!J$7$s$$$;$$$O$$$H$&!K(B$B!!(B67$B!KC]MU@P9QEr!J$A$/$h$&$;$C$3$&$H$&!K(B
$B!!(B68$B!K?@@gB@259Q!J$7$s$;$s$?$$$D$3$&!K(B

$B!!!v$=$NB>87A*4AJ}Lt(B

$B87A*7r9/?)IJ(B
$B!!#1!K%"%,%j%/%9pyN3%7%s%o(B$B!!#2!K6(OB%"%,%j%/%9B{(B$B!!#3!KED<7(B$B!!#4!K1@Fn5.@:(B$B!!#5!K%"%9%j!<%V(B$B!!#6!KE7A3E_Cn2FAp%+%W%;%k(B$B!!(B
$B!!#7!KD65i(B $BM[?@pyN3!J$h$&$8$s$+$j$e$&!K(B$B!!#8!KW"A5pyN3!J$3$&$<$s$+$j$e$&!K(B$B!!#9!K%W%m%]%J!<%k!&%9!<%Q!<%(%-%9%H%i(B 60ml $B!J%W%m%]%j%9!K(B
$B!!(B10$B!K%$%`%N%(!<%9!J(BAHCC$B!K(B$B!!(B11$B!K%*%l%s%8%Y%M%U%#%s!J%5%aFp9|!K(B$B!!(B12$B!KE7A3%a%7%^%3%V(B$B!!(B13$B!KE7A3%d%^%V%7%?%1(B
$B!!(B14$B!K6(OB$N%3%l%9%F%V%m%C%/#C#S#P#H#PN3(B$B!!(B15$B!KE7A3%A%c!<%,!J%+%P%N%"%J%?%1!"%7%i%+%P%?%1!"%7%Y%j%"Nn$B!!(B
$B!!(B16) $B$B!!(B17$B!K(B $B%0%j!<%s%(%3!$B!!(B18$B!K%3(B-$B%-%e%&%F%s!J%3%(%s%6%$%`(BQ10$B!K(B
$B!!(B19) JPS $B=g5$;6!J%8%e%s%-%5%s!K(B $B!!(B20$B!K%7%k%-!<%3%i!<%2%s(B$B!!(B21$B!K%<%j!<%8%e!<%9%$%5%4!<%k(B$B!!(B22$B!K@a!93Z:B!J$U$7$V$7$i$/$6!K(B
$B!!(B23$B!K5H>MAINnW"!J$-$C$7$g$&$=$l$$$3$&!K(B$B!!(B24$B!K2wJb3Z!J$+$$$[$i$/!K(B$B!!(B25$B!KD65i(B $BW"A5pyN3!J$A$g$&$-$e$&$3$&$<$s$+$j$e$&!K(B
$B!!(B26$B!K%$%_%e%J%C%W!&%4!<%k%I!J(BIMYUNAP GOLD$B!K(B $B!!(B27$B!K%^%D%&%iHDMu:,!J$P$s$i$s$3$s!K%(%-%9:YN3(B $B!!%<%j!<%8%e!<%9%$%5%4!<%k%W%i%9(B
$B!!(B28$B!K%$%5%4!<%k%W%i%9(B $B!!(B29$B!K7rD43Z!J$1$s$A$g$&$i$/!K(B$B!!(B30$B!K;3IzG5;r6L!J$d$^$V$7$N$7$.$g$/!K(B$B!!(B31$B!K
$B!!(B32$B!K%U%'%+%j%s!!F};@6]!J#F#K(B-$B#2#36]!a%(%s%F%m%3%C%+%9%U%'%+%j%96]!K4^M-?)IJ(B $B%U%'%+%j%s#2#0!"%U%'%+%j%s#8#0(B$B!!%U%'%+%j%s#3#0!"%U%'%+%j%s#1#2#0(B
$B!!(B33$B!K3h5$;2!J9bNo9H;2Cc!K(B$B!!(B33$B!K%(%-%J%1%"$N$I0;(B $B!!(B34$B!K8$B!!(B35$B!K
$B!!(B36$B!KE_Cn2FAp(B $B!!(B63$B!KHDMu:,%(%-%9!J$P$s$i$s$3$s%(%-%9!K(B

$B!!!v$=$NB>87A*7r9/?)IJ(B

$BBg;34AJ}F2Lt6I!!Gd$j@Z$j!*FCJL3d0z!*$4Jt;EIJ!*(B
$B-!%"%,%j%/%9pyN3%7%s%o-"6(OB%"%,%j%/%9B{(B $B-#%d%^%V%7%?%1(B $B-$

$B!V45I>u!"BN $B!V$^$:$O!"$*EEOC$/$@$5$$!#!!(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!JIT0B!K%J%7!K!W(B

$BGSMqF|8!::Lt!"G%?18!::Lt(B

$B!!#1!K%_%:%[GSMqF|8!::Lt!!(BP-CHECK$B!&(BLH$B!J(BP-$B%A%'%C%/!&(BLH$B!K(B
$B!!#2(B) $B%_%:%[G%?18!::Lt!!(BP-CHECK$B!&(BS$B!J(BP-$B%A%'%C%/!&(BS$B!K(B

$B$=$NB>!J4AJ}Lt$N<+F0@y$84oB>!K(B
$B!!#1!KFJK\E73$F2!VJ82P3Z!9!J$H$m$S$i$s$i$s!K!W(B$B!!#2(B) $B%&%A%@OB4ALt!V@y<#!J$;$s$8!K!W(B$B!!(B
$B!!#3!KF|K\@8Lt!VLt@y!J$d$/$;$s!K!W(B$B!!#4(B) $B%,!<%G%$#V%^%9%/!J%&%$%k%946@wKI;_MQ%^%9%/!K(B
$B!!#5(B) $B%D%`%i$NH/LSB%?J:^(B $B%$%s%;%s%H!V%b%&%,!JLS2j!K!W(B$B!!#6(B) $B%V%i%$%H%K%s%0%Q%W%i!<%k%m!<%7%g%s!"%/%j!<%`(B $B!!(B
$B!!#7(B) $B%Q%W%i!<%k%W%i%A%i%$%J!<%=!<%W!"%Q%W%i!<%k%W%i%A%i%$%J!<%&%*%C%7%e!!(B$B!!%Q%W%i!<%k(BUV$B%Y!<%9!!(B
$B!!#8(B) $B%&%A%@OB4ALt(B $B#I#HBP1~<+F0@y$84o(B $B!V$i$/$i$/@y!J$i$/$i$/$;$s!K!W(B$B!!(B
$B!!#9(B) $B:G?7<0(B $B%&%A%@OB4ALt<+F0@y$84o(B $B!V%^%$%3%s@y$84o#3!J$;$s$8$-%9%j!$B!!(B
$B!!(B10) $B%A%Y%C%H9b86!!!V4d1vIwO$!W(B$B!!(B11) $B2L
$B!!(B12$B!K%9%?%"%_%s(B hi $B%7%j!<%:!JL5Ce?'!"L59aNA!" $B!!(B12-$B-!%9%?%"%_%s(B hi $B%/%j!<%`!JLtMQ@0H)%/%j!<%`!K(B$B!!(B12-$B-"%9%?%"%_%s(B hi $B%m!<%7%g%s!J2=>Q?e!K(B

$B!!!!(B$B!!?73+H/!*(B $B%D%`%i$NH/LSB%?J:^(B $BLtMQ%$%s%;%s%H(B $B!V%b%&%,!JLS2j!K!W!*!*?7H/Gd!*!*!*(B
$B!!!!!!!!!!!!!!!v@8Lt%7%J%8!<8z2L$GLSJq:YK&$rA}?#$5$;?<$/:,6/$$H1$K$9$k!*!*!*(B
$B!!!!!!!!!V8zG=!&8z2L!aH/LSB%?J!"C&LSM=KI!"LS@8B%?J!"0iLS!"GvLS!"M\LS!"$U$1!"$+$f$_!W!*!*!*(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!Bg;34AJ}F2Lt6I$G!"$*
$B!J3t!K%&%A%@OB4ALt!!(B $B>>1:4AJ}!J3t!K!!(B$B!J3t!KFJK\E73$F2!!(B $B?-OB@=Lt!J3t!K!!(B $B!J3t!K7zNS>>DaF2!!(B JPS$B@=Lt!!(B $B!J3t!K%D%`%i(B

$B!!(B* $B>e5-!"#7$D$NFCLs%a!<%+!<$N>&IJ$O!"$9$Y$F$*

$B!VBg;34AJ}F2Lt6I(B NEWS $B:G?7>pJs(B !!! $B!W(B

$B!!!!(B$B!!!!(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B4AJ}@lLg(B $BBg;34AJ}F2Lt6I(B
$B:G?7%D%`%i4AJ}%(%-%9@=:^A4IJL\$N2r@b(B
Dr. HIROYUKI OHYAMA, Ph.D.

No $B=hJ}L>(B $B-!8zG=!&8z2L!!-";HMQL\I8!a>Z!!-#Lt8z!&LtM}(B $B9=@.@8Lt!&G[9gHf(B
001 $B%D%`%i3k:,Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$C$3$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B<+A3H/4@$,$J$/F,DK!"H/G.!"0-4(!"8*$3$jEy$rH<$&Hf3SE*BNNO$N$"$k$b$N$NI!'46KA!"I!$+$I@-<@45(B($B7kKl1j!"3QKl1j!"Cf<*1j!"Y(EmA#1j!"F}A#1j!"%j%s%QA#1j(B)$B!"8*$3$j!">eH>?H$N?@7PDK!"$8$s$^$7$s(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"1j>I@-$"$k$$$OaVDK@-<@45$N=i4|!"$"$k$$$OK}@-<@45!J8zG=!&8z2L;2>H!K$N5^@-A}0-4|$KMQ$$$k!#(B
$B#1!K46KA$J$I$NG.@-<@45$G$O!"=i4|$G0-4(!"H/G.!"F,DK!"9`GXIt$N$3$o$P$j$J$I$,$"$C$F!"<+A3H/4@$rH<$o$J$$>l9g!#(B
$B#2!KaVDK@-<@45$G$O6I=j$NaVDK!"l9g!#(B
$B#3!K45It$,H/@V!"l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$B#2!%%$%s%U%k%(%s%6%&%#%k%946@w>I$KBP$9$k:nMQ!J%^%&%9!K(B
$B#3!%%5%$%H%+%$%s$KBP$9$k:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x!!%W%m%9%?%0%i%s%8%s#E(B2$B!J#P#G#E(B2$B!K$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%+%C%3%s!D(B4.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%^%*%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B2.0g
002 $B%D%`%i3k:,Er2C@n5]?I0P(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$C$3$s$H$&$+$;$s$-$e$&$7$s$$(B
$B-!!V8zG=!&8z2L!W(B
$BI!$E$^$j!"C_G?>I!"K}@-I!1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"I!JD!"I!O3!"8eI!O3$J$I$NI!>I>u$rAJ$(!"$3$l$i$N>I>u$,$H$/$KK}@-2=$7$?>l9g$KMQ$$$k!#(B
$B#1!KF,DK!"F,=E!"9`GXIt$N$3$o$P$j$J$I$rH<$&>l9g!#(B

$BF|6I%+%C%3%s!D(B4.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%^%*%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%7%s%$!D(B2.0g
003 $B%D%`%i25;zEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$D$8$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIB>u$,$=$l$[$I7c$7$/$J$/!"BNNO$,Cf0L$G?jI(B:$B%-%l<&!"%$%\<&(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$N<&<@45$G!">I>u$N$"$^$j7c$7$/$J$$$b$N$KMQ$$$k!#(B
$B#1!KJXHk$N798~$N$"$k>l9g!#(B
$B#2!KfjLg$^$?$O1"It$NaVDK$dGBaZ$rH<$&>l9g!#(B
$B#3!K7ZEY$N=P7l$rH<$&>l9g!#(B

$BF|6I%H%&%-!D(B6.0g,$BF|6I%5%$%3!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%^!D(B1.0g,$BF|6I%@%$%*%&!D(B0.5g
005 $B%D%`%i0BCf;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$"$s$A$e$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$d$;7?$GJ"It6ZFy$,CP4K$9$k798~$K$"$j!"0_DK$^$?$OJ"DK$,$"$C$F!"$H$-$K6;$d$1!"$2$C$W!"?)M_IT?6!"$O$-$1$J$I$rH<$&I(B:$B?@7P@-0_1j!"K}@-0_1j!"0_%"%H%K!<(B

$B-"!V;HMQL\I8!a>Z!W(B
$BAi$;7?$GHf3SE*BNNO$NDc2<$7$??M$NK}@-$K7P2a$9$k0_DK$d6;$d$1$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K?)J*$N>C2=$,0-$/!"?4c]ItKDK~46!"0-?4!"SREG$J$I$rAJ$($k>l9g!#(B
$B#2!KJ"It$OFpl9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%(%s%4%5%/!D(B3.0g,$BF|6I%\%l%$!D(B3.0g,$BF|6I%&%$%-%g%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%e%/%7%c!D(B1.0g,$B%j%g%&%-%g%&!D(B0.5g
006 $B%D%`%i==L#GTFGEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$e$&$_$O$$$I$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B2=G?@-HiIf<@45!&5^@-HiIf<@45$N=i4|!"$8$s$^$7$s!"5^@-<>?>!"?eCn(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$NHiIf<@45$G!"45It$O;6H/@-$"$k$$$O!"$S$^$s@-$NH/?>$GJ$$o$l!"^z=P1U$N>/$J$$>l9g$KMQ$$$k!#(B
$B#1!K45It$K2=G?$rH<$&$+$"$k$$$O2=G?$r$/$jJV$9>l9g!#(B
$B#2!K5(O>2l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$B#2!%:nMQ5!=x(B
$B!J#1!K9%Cf5e3h@-2=:nMQ!J(Bin vitro$B!K(B
$B!J#2!K3h@-;@AG$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!J#3!KHiIf3Q2=$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%-%-%g%&!D(B3.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%&%U%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%\%/%=%/!D(B3.0g,$B%I%C%+%D!D(B1.5g
007 $B%D%`%iH,L#CO2+4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$A$_$8$*$&$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BHhO+!"7qBU46Cx$7$/!"G"Mx8:>/$^$?$OIQ?t!"8}3i$7!"I(B:$B?U1j!"E|G"IB!"1"0`!":A9|?@7PDK!"9xDK!"5S5$!"g/fy%+%?%k!"A0N)A#HnBg!"9b7l05(B

$B-"!V;HMQL\I8!a>Z!W(B
$BCfG/0J9_;~$KO7Npo!JFC$KLk4V$NIQG"!K$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K>eJ"It$KHf$Y$F2l9g!JgA2 $B#2!KB?G"!"IQG"!"K3G"!"GSG"DK$J$I$rH<$&>l9g!#(B
$B#3!KHhO+7qBU46!"9xDK!"8}3i$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%E|G"IBM^@):nMQ!J%i%C%H!K(B
$B#2!%=[4D4o7O$KBP$9$k:nMQ!J%&%5%.!"%^%&%9!K(B
$B#3!%9|Be $B#4!%B$@:5!G=$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#5!%MxG":nMQ!J%i%C%H!K(B
$B#6!%7l059_2<:nMQ!J%i%C%H!K(B
$B#7!%?UB!$KBP$9$k:nMQ!J%i%C%H!K(B
$B#8!%:nMQ5!=x(B
$B!J#1!K%"%k%I!<%9%j%@%/%?!<% $B!J#2!KB$@:5!G=$KBP$9$k:nMQ!J%i%C%H!K(B

$BF|6I%8%*%&!D(B6.0g,$BF|6I%5%s%7%e%f!D(B3.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B2.5g,$BF|6I%1%$%R!D(B1.0g,$B=$<#%V%7Kv!D(B0.5g
008 $B%D%`%iBg $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$5$$$3$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$N$"$k?M$G!"JXHk$,$A$G!">eJ"It$,D%$C$F6l$7$/!"<*LD$j!"8*$3$j$J$IH<$&$b$N$NI(B:$BC@@P>I!"C@$N$&1j!"2+aU!"4N5!G=>c32!"9b7l05>I!"G>0n7l!"$8$s$^$7$s!"0_;@2aB?>I!"5^@-0_D2%+%?%k!"0-?4!"SREG!"?)M_IT?6!"<&<@!"E|G"IB!"%N%$%m!<%I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!&BNNO$H$b$K=<l9g$KMQ$$$k!#(B
$B#1!K0-?4!"SREG!"5(O>It$N6lK~46$J$I$rH<$&>l9g!#(B
$B#2!K8*$3$j!"F,DK!"F,=E!"$a$^$$!"<*LD$j$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%4N>c32M^@):nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B#2!%4N$N;i $B#3!%C@@P7A@.M^@):nMQ!J%O%`%9%?! $B#4!%93%"%l%k%.!<:nMQ!J%&%5%.!"%i%C%H!"%^%&%9!K(B
$B#5!%=[4D7O$KBP$9$k:nMQ!J%&%5%.!"%i%C%H!"%^%&%9!K(B
$B#6!%:nMQ5!=x(B
$B!J#1!K4N$N;i $B!J#2!K4N$N;i
$BF|6I%5%$%3!D(B6.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%@%$%*%&!D(B1.0g
009 $B%D%`%i>. $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$5$$$3$H$&(B
$B-!!V8zG=!&8z2L!W(B
I.$BBNNOCfEyEY$G>eJ"It$,$O$C$F6l$7$/!"@eB]$r@8$8!"8}CfIT2w!"?)M_IT?6!";~$K$h$jHyG.!"0-?4$J$I$N$"$k$b$N$NI(B:$B=tc32!";:8e2sI|ITA4!!(B
II.$BK}@-4N1j$K$*$1$k4N5!G=>c32$N2~A1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G6;OF6lK~$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KG.@-<@45$G$O?)M_IT?6!"8}CfIT2w46$J$I$rH<$&>l9g!#(B
$B#2!K6;OF6lK~$NG'$a$i$l$k=tH!K(B
$B#3!K?)M_IT?6!"A4?H7qBU46$J$I$rH<$&=tH(B
$B#4!K5u.;y$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%4N>c32M^@):nMQ!J%i%C%H!K(B
$B#2!%4N7lN.NLDc2 $B#3!%4N:F@8B%?J:nMQ!J%i%C%H!K(B
$B#4!%4N@~0]2=M^@):nMQ!J%i%C%H!K(B
$B#5!%LH1VD4@0:nMQ!J%^%&%9!K(B
$B#6!%LH1VJ#9gBN=|5n:nMQ!J%^%&%9!K(B
$B#7!%93%"%l%k%.!<:nMQ!J%b%k%b%C%H!K(B
$B#8!%931j>I:nMQ!J%i%C%H!K(B
$B#9!%:nMQ5!=x(B
$B!J#1!K4N>c32M^@):nMQ!J(Bin vitro$B!K(B
$B!J#2!K4N@~0]2=M^@):nMQ!J(Bin vitro$B!K(B
$B!J#3!KLH1VD4@0:nMQ!J%i%C%H!"%^%&%9!"(Bin vitro$B!K(B
$B!J#4!K93%"%l%k%.!<:nMQ!J(Bin vitro$B!K(B
$B!J#5!K931j>I:nMQ!J(Bin vitro$B!K(B
$B!J#6!K3h@-;@AGM^@):nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B7.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,
010 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$1$1$$$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BH/G.4@=P$F!"0-4($7!"?HBNDK$_!"F,DK!"$O$-$1$N$"$k$b$N$NI(B:$B46KA!&N.46!&GY1j!&GY7k3K$J$I$NG.@-<@45!"0_DYag!&==Fs;XD2DYag!&C@$N$&1j!&C@@P!&4N5!G=>c32!&g9B!1j$J$I$N?42
$B-"!V;HMQL\I8!a>Z!W(B
$BG.@-<@45$G$O!"5^@-4|$r7P$F$J$*F,DK!"0-46!"4X@aDK!"?)M_IT?6$J$I$N$"$k>l9g$KMQ$$$k!#K}@-<@45$G$O!"?4c]It$h$j5(O>It$K$+$1$F6lK~46$rAJ$(!"Dq93!&05DK$,G'$a$i$l!J6;OF6lK~!K!"J"D>6Z$NZ;5^$rH<$&>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$N6lK~46!"?)M_IT?6!"J"DK$J$I$rH<$&>l9g!#(B
$B#2!K@:?@IT0B!"ITL2$J$I$N@:?@?@7P>I>u$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93DYag:nMQ!J%i%C%H!K(B
$B#2!%4N>c32M^@):nMQ!J%i%C%H!"%^%&%9!K(B
$B#3!%g91jM^@):nMQ!J%i%C%H!K(B
$B#4!%:nMQ5!=x(B
$B!J#1!K93DYag:nMQ!J(Bin vitro$B!K(B
$B!J#2!Kg91jM^@):nMQ!J(Bin vitro$B!K(B
$B!J#3!KLH1VD4@0:nMQ!J(Bin vitro$B!K(B
$B!J#4!K>C2=4I%[%k%b%s$KBP$9$k:nMQ!J%i%C%H!K(B
$B!J#5!K3h@-;@AG>C5n:nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
011 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$1$$$7$+$s$-$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO$,I!"IO7l5$L#$G!"F0X)!"B)@Z$l$,$"$j!"?@7P2aIR$N$b$N$NI(B:$B99G/4|>c32!"7l$NF;>I!"?@7P>I!"ITL2>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"4i?'$,$9$0$l$:!"HhO+7qBU46$,$"$j!"F0X)!"B)@Z$l!"ITL2$J$I$N@:?@?@7P>I>u$rH<$&>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$h$j5(O>2l9g!#(B
$B#2!K0-4(!"HyG.!"Ep4@!"8}3i$J$I$rH<$&>l9g!#(B

$BF|6I%5%$%3!D(B6.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%+%m%3%s!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%\%l%$!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$B%+%s%-%g%&!D(B2.0g
012 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$+$j$e$&$3$D$\$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"?4X)P6?J!"ITL2!"$$$i$@$AEy$N@:?@>I>u$N$"$k$b$N$NI(B:$B9b7l05>I!"F0L.9E2=>I!"K}@-?UB!IB!"?@7P?jI!"?@7P@-?4X)P6?J>I!"$F$s$+$s!"%R%9%F%j!.;yLkSF>I!"1"0`(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"@:?@IT0B!"ITL2!"$$$i$$$i$J$I$N@:?@?@7P>I>u$,$"$j!"6;OF6lK~$N$"$k>l9g!#(B
$B#1!KF,DK!"F,=E!"8*$3$j$J$I$rH<$&>l9g!#(B
$B#2!KgAK5$KJ"ItBgF0L.$NGoF0$NP6?J$rG'$a$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93F0L.9E2=:nMQ!J%&%5%.!"%i%C%H!K(B
$B#2!%DC@E:nMQ!J%^%&%9!K(B
$B#3!%93a[Z;:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!!!!!!93F0L.9E2=:nMQ!J%^%&%9!"(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%?%$%=%&!D(B2.5g,$BF|6I%K%s%8%s!D(B2.5g,$BF|6I%\%l%$!D(B2.5g,$BF|6I%j%e%&%3%D!D(B2.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
014 $B%D%`%iH>2F_C?4Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$s$2$7$c$7$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$_$>$*$A$,$D$+$(!"$H$-$K0-?4!"SREG$,$"$j?)M_IT?6$GJ"$,LD$C$FFpJX$^$?$O2I(B:$B5^!&K}@-0_D2%+%?%k!"H09Z@-2C2=ITNI!"0_2I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?4c]It$NKDK~46!"J"CfMkLD$,$"$j!"0-46!"SREG!"2l9g$KMQ$$$k!#(B
$B#1!K?)M_IT?6!"7ZEY$N>eJ"ItDK$J$I$rH<$&>l9g!#(B
$B#2!KIT0B!&ITL2$J$I$N@:?@?@7P>I>u$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B!L%R%H$G$N:nMQ!M(B
$B!!!!0_GS=PB%?J:nMQ(B
$B!LF0J*$G$N:nMQ!M(B
$B!!!!#1!%0_GS=PB%?J:nMQ!J%i%C%H!K(B
$B!!!!#2!%0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!K(B
$B!!!!#3!%@)EG:nMQ!J%U%'%l%C%H!K(B
$B!!!!#4!%;__C:nMQ!J%i%C%H!"%^%&%9!K(B
$B!!!!#5!%:nMQ5!=x(B
$B!!!!!!!J#1!K0_G4KlKI8f:nMQ!J%i%C%H!K(B
$B!!!!!!!J#2!K931j>I:nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B!!!!!!!J#3!KBgD2?eJ,5[<}P6?J:nMQ!J%i%C%H!K(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%+%s%>%&!D(B2.5g,$BF|6I%?%$%=%&!D(B2.5g,$BF|6I%K%s%8%s!D(B2.5g,$BF|6I%*%&%l%s!D(B1.0g,$B%+%s%-%g%&!D(B2.5g
015 $B%D%`%i2+O"2rFGEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$&$l$s$2$I$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"$N$\$;5$L#$G!"$$$i$$$i$9$k798~$N$"$k$b$N$NI(B:$BS=7l!"EG7l!"2<7l!"G>0n7l!"9b7l05!"?4X)P6?J!"%N%$%m!<%I!"0_1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"$N$\$;5$L#$G4iLL9HD,$7!"@:?@IT0B!"ITL2!"%$%i%$%i$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$NKDK~46$rAJ$($k>l9g!#(B
$B#2!KS=7l!"EG7l!"2<7l$J$I$N=P7l$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%=[4D7O$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!K(B
$B#3!%931j>I:nMQ!J%i%C%H!"%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!K7l>.HD6E=8M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%*%&%l%s!D(B2.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%*%&%P%/!D(B1.5g
016 $B%D%`%iH>2F8|KQEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$s$2$3$&$\$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5$J,$,$U$5$$$G!"0v9"!"?)F;It$K0[J*46$,$"$j!"$H$-$KF0X)!"$a$^$$!"SR5$$J$I$rH<$&I!'IT0B?@7P>I!"?@7P@-0_1j!"$D$o$j!"$;$-!"$7$o$,$l@I!"ITL2>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY0J2<$N?M$G!"4i?'$,$9$0$l$:!"?@7P>IE*798~$,$"$j!"0v9"$,:I$,$k46$8!J$$$o$f$k%R%9%F%j!<5e!K$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K5$J,$,$U$5$.!"ITL2!"F0X)!"@:?@IT0B$J$I$rAJ$($k>l9g!#(B
$B#2!K8F5[:$Fq!"31SV!"6;DK$J$I$rH<$&>l9g!#(B
$B#3!K?4c]It$N?6?e2;$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
017 $B%D%`%i8^Nj;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$l$$$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B8}3i!"G"NL8:>/$9$k$b$N$NI(B:$BIbI!"=k5$$"$?$j!"E|G"IB(B

$B-"!V;HMQL\I8!a>Z!W(B
$B8}3i$J$i$S$KMxG"8:>/$r $B#1!KIbI>u$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%"%k%3!<%kBe $B#2!%MxG":nMQ!J%i%C%H!K(B
$B#3!%>C2=4I1?F0P6?J:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!!!!MxG":nMQ!J(Bin vitro$B!K(B

$BF|6I%?%/%7%c!D(B4.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%1%$%R!D(B1.5g
018 $B%D%`%i7K;^2C[2ImEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$8$e$D$V$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"?@7PDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BNd$(@-$GHf3SE*BNNO$NDc2<$7$??M$,!";M;h4X@a$NaVDK!"c32$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K4X@aDK$,$"$j!"4(Nd$K$h$jA~0-$9$k>l9g!#(B
$B#2!KHyG.!"Ep4@!"D+$N/$J$I$rAJ$($k>l9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B=$<#%V%7Kv!D(B0.5g
019 $B%D%`%i>.@DN5Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$;$$$j$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
1 $B2<5-<@45$K$*$1$k?eMM$Nab!"?eMMI!=A!"I!JD!"$/$7$c$_!"SCLD!"31SV!"N.N^!!5$4I;YSCB)!"I!1j!"%"%l%k%.!]@-I!1j!"%"%l%k%.!]@-7kKl1j!"46KA!!(B2 $B5$4I;Y1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"SCLD!"31SV!"8F5[:$Fq!"I!>I>u$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KK"Kw?eMM@-$Nab!"?eMM@-I!=A!"$/$7$c$_$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!I:nMQ!J%b%k%b%C%H!"%i%C%H!"(Bin vitro$B!K(B
$B#2!%%&%#%k%946@w$KBP$9$k:nMQ!J%^%&%9!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K%1%_%+%k%a%G%#%(!<%?!<;:@8!&M7N%M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K1j>I:YK&$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K%"%;%A%k%3%j%s;I7c$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#4!K%&%#%k%946@w$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%4%_%7!D(B3.0g,$BF|6I%5%$%7%s!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%^%*%&!D(B3.0g,$B%+%s%-%g%&!D(B3.0g
020 $B%D%`%iKI8J2+fMEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$\$&$$$*$&$.$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?'Gr$G6ZFyFp$i$+$/?e$V$H$j$NBN.JXITMx$G2<;h$KIbI!'?U1j!"%M%U%m!<%I!"4X@a1j!"a~!"$;$D!"6Z1j!"IbI!"7n7PIT=g(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$,Dc2<$7?'Gr$G6ZFy=@$i$+$/!"$$$o$f$k?e$V$H$jBNl9g$KMQ$$$k!#(B
$B#1!KIb/!"4X@a!J$H$/$KI(4X@a!K$Nl9g!#(B

$BF|6I%*%&%.!D(B5.0g,$BF|6I%\%&%$!D(B5.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
021 $B%D%`%i>.H>2F2Ch*NjEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$O$s$2$+$V$/$j$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNOCfEyEY$NI(B:$BG%?1SREG(B($B$D$o$j(B)$B!"$=$N$[$+$N=tIB$NSREG(B($B5^@-0_D21j!"<>@-6;Kl1j!"?eI(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"0-?4!"SREG$rl9g$KMQ$$$k!#(B
$B#1!KSREG$O>/$7$:$D2?2s$bEG$-!"EG$$$?8e$b0-?4$N;D$k$h$&$J$b$N$G$"$k!#(B
$B#2!K?4c]It$N$D$+$(46!"$a$^$$!"F0X)$J$I$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
022 $B%D%`%i>CIw;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$U$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BJ,HgJ*$,B?$/!"$+$f$_$N6/$$K}@-$NHiIfIB(B($B<>?>!"i!Kc?>!"?eCn!"$"$;$b!"HiIf$=$&aZ>I(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$NK}@-$NHiIf<@45$G!"45It$KG.46$,$"$C$F!"B?$/$O<>=a$7!"GBaZ$N$O$J$O$@$7$$>l9g$KMQ$$$k!#(B
$B#1!K4h8G$JHi?>$G!"J,HgJ*$,$"$C$FaPHi$r7A@.$7!"$=$N308+$,1xcR$GCOH)$K@VL#$rBS$S!"8}3i$rAJ$($k>l9g!#(B
$B#2!KHiIf$NIBJQ$,2F4|$K$`$+$C$F!"A~0-$9$k798~$N$"$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%R%9%?%_%s:nMQ!J%$%L!K(B
$B#2!%93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K93%R%9%?%_%s:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B
$BF|6I%;%C%3%&!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%=%&%8%e%D!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%b%/%D%&!D(B2.0g,$BF|6I%A%b!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%/%8%s!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$B%4%\%&%7!D(B2.0g,$B%4%^!D(B1.5g,$B%<%s%?%$!D(B1.0g
023 $B%D%`%iEv5"giLt;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$7$c$/$d$/$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B6ZFy$,0lBN$KFpI!'IO7l!"7qBU46!"99G/4|>c32(B($BF,=E!"F,DK!"$a$^$$!"8*$3$jEy(B)$B!"7n7PIT=g!"7n7P:$Fq!"ITG%>I!"F0X)!"K}@-?U1j!"G%?1Cf$N=tIB(B($BIb?HIT?q!"?4B!J[Kl>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?@.?M=w;R$KMQ$$$i$l$k$3$H$,B?$/!"0lHL$KNd$(>I$GIO7l798~$,$"$j!"@-<~4|$KH<$C$F7PEY$NIbl9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!";M;hNd46!"F,DK!"$a$^$$!"<*LD!"8*$3$j!"?4X)P6?J$J$I$N>I>u$rAJ$($k>l9g!#(B
$B#2!KL57n7P!"2aB?7n7P!"7n7P:$Fq$J$I!"7n7P0[>o$N$"$kIX?M!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%[%k%b%s$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%GSMqM6H/:nMQ!J%i%C%H!K(B
$B#3!%7l1U6E8G7O$KBP$9$k:nMQ!J%i%C%H!K(B
$B#4!%?UJ]8n:nMQ!J%i%C%H!K(B
$B#5!%99G/4|>c32$KBP$9$k:nMQ!J%^%&%9!K(B
$B#6!%:nMQ5!=x(B
$B!!!J#1!K%[%k%b%s$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K;R5\$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K7l1U6E8G7O$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#4!K%U%j!<%i%8%+%k>C5n:nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B!!!J#5!K%"%i%-%I%s;@%+%9%1!<%I$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%?%/%7%c!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g
024 $B%D%`%i2CL#mvMZ;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$_$7$g$&$h$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BBNI>u!"$H$-$KJXHk$N798~$N$"$kI(B:$BNd$(>I!"5uc32!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*5uI>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K8*$3$j!"F,DK!"$a$^$$!">eH>?H$N<^G.46!"H/:n@-$NH/4@$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It!&5(O>It$K7ZEY$NDq93!&05DK$N$"$k>l9g!#!J6;OF6lK~!K(B
$B#3!K@-<~4|$K4XO"$7$F>e5-@:?@?@7P>I>u$rAJ$($k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%99G/4|>c32$KBP$9$k:nMQ!J%^%&%9!K(B
$B#2!%:nMQ5!=x(B
$B!!!!!!!!FbJ,Hg7O$X$N:nMQ!J%^%&%9!K(B

$BF|6I%5%$%3!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%\%?%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%O%C%+!D(B1.0g
025 $B%D%`%i7K;^h*Nj4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$V$/$j$g$&$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BBN3J$O$7$C$+$j$7$F$$$F@V$i4i$,B?$/!"J"It$OBgBN=<I(B:$B;R5\JB$S$K$=$NIUB04o$N1j>I!";R5\FbKl1j!"7n7PIT=g!"7n7P:$Fq!"BS2c32(B($BF,DK!"$a$^$$!"$N$\$;!"8*$3$jEy(B)$B!"Nd$(>I!"J"Kl1j!"BGKP>I!"<&<@45!"bP4]1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"$N$\$;$F@V$i4i$N$3$H$,B?$/!"2l9g$KMQ$$$k!#1w7l$KH<$&=t>I>u$KMQ$$$k!#(B
$B#1!KF,DK!"8*$3$j!"$a$^$$!"$N$\$;!"B-$NNd$($J$I$rH<$&>l9g!#(B
$B#2!KL57n7P!"2aB?7n7P!"7n7P:$Fq$J$I7n7P0[>o$N$"$kIX?M!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%[%k%b%s$KBP$9$kD4@a:nMQ!J%i%C%H!K(B
$B#2!%;R5\$KBP$9$k:nMQ!J%^%&%9!K(B
$B#3!%99G/4|>c32$KBP$9$k:nMQ!J%i%C%H!K(B

$BF|6I%1%$%R!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%H%&%K%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B3.0g
026 $B%D%`%i7K;^2CN59|24iZEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$j$e$&$3$D$\$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B2J"6Z$K6[D%$N$"$kHf3SE*BNNO$N?j$($F$$$k$b$N$NI(B:$B>.;yLkG">I!"?@7P?j
$B-"!V;HMQL\I8!a>Z!W(B
$BBNl9g$KMQ$$$k!#(B
$B#1!K1"0`!"0d@:$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#2!K0WHhO+46!"Ep4@!"l9g!#(B
$B#3!KJ"It$,Fpl9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%\%l%$!D(B3.0g,$BF|6I%j%e%&%3%D!D(B3.0,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
027 $B%D%`%iKc2+Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$*$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0-4(!"H/G.!"F,DK!"9xDK!"<+A3$K4@$N=P$J$$$b$N$NI(B:$B46KA!"%$%s%U%k%(%s%6(B($B=i4|$N$b$N(B)$B!"4X@a%j%&%^%A!"SCB)!"F};y$NI!JD:I!"S.F}:$Fq(B

$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$+$i>fIW$GBNNO=<l9g$KMQ$$$k!#(B
$B#1!KSCLD!"31SV$J$I$rH<$&>l9g!#(B
$B#2!KF}MD;y$N46KA$G!"I!JD:I$N$"$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%&%#%k%9A}?#M^@):nMQ!J(Bin vitro$B!K(B
$B#2!%931j>I:nMQ!J%i%C%H!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K931j>I:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!KH/G.$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%-%g%&%K%s!D(B5.0g,$BF|6I%^%*%&!D(B5.0,$BF|6I%1%$%R!D(B4.0g,$BF|6I%+%s%>%&!D(B1.5g
028 $B%D%`%i1[U92C[2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$($C$T$+$8$e$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIb.JXITMx$N$"$k$b$N$NI(B:$B?U1j!"%M%U%m!<%I!"<>?>(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"Ib/$9$k>l9g$KMQ$$$k!#(B
$B#1!K;M;h4X@a$Nl9g!#(B

$B-#!VLt8z!&LtM}!W(B
$BHiIf1j$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%;%C%3%&!D(B8.0g,$BF|6I%^%*%&!D(B6.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
029 $B%D%`%iG~LgE_Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$P$/$b$s$I$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$Bab$N@Z$l$K$/$$31!"5$4I;Y1j!"5$4I;Y$<$s$=$/(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J2<$N?M$N7c$7$$31SV$G!"H/:n@-$K31$,IQH/$7$F4iLL9HD,$9$k>l9g$KMQ$$$k!#(B
$B#1!KG4cG$G@Z$l$K$/$$ab$rH<$&>l9g!#(B
$B#2!K0v9"$N4%Ag46$d0cOB46$N$"$k>l9g!#(B
$B#3!K>e5->I>u$rH<$&O7?M$N31SV!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%DC31:nMQ!J%b%k%b%C%H!K(B
$B#2!%5nab:nMQ!J%&%:%i!K(B
$B#3!%5$4I;Y3HD%:nMQ!J%b%k%b%C%H!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!K5nab:nMQ!J%&%:%i!"(Bin vitro$B!K(B
$B!!!J#2!K93%"%l%k%.!<:nMQ!J(Bin vitro$B!K(B

$BF|6I%P%/%b%s%I%&!D(B10.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$B%3%&%Y%$!D(B5.0g
030 $B%D%`%i??IpEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$s$V$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?7DDBeI(B:$B0_D2<@45!"0_D25uI!"K}@-D21j!">C2=ITNI!"0_%"%H%K!<>I!"0_2I!"%M%U%m!<%0n7l!"@T?q<@45$K$h$k1?F0$J$i$S$KCN3PKcac!"?@7P?jI!"?4B!J[Kl>I!"?4ITA4$G?4X)P6?J!"H>?HIT?q!"%j%&%^%A!"O7?M@-$=$&aZ>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$B?7DDBel9g$KMQ$$$k!#(B
$B#1!KK\J}$N2 $B#2!K$a$^$$!"?HBNF0MI46!"?4X)P6?J$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B7l059_2<:nMQ!J%i%C%H!K(B

$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g,$B=$<#%V%7Kv!D(B0.5g
031 $B%D%`%i8bh%hPEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$7$e$f$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI(B:$B=,47@-JPF,DK!"=,47@-F,DK!"SREG!"5S5$!">W?4(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?Nd$(>I$N?M$G!"H?I|@-$K5/$3$k7c$7$$F,DK$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K9`$d8*$N$3$j!"SREG$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$KKDK~46!"a]:I46$"$k$$$O?6?e2;$rG'$a$k>l9g!#(B
$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%4%7%e%f!D(B3.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
032 $B%D%`%i?M;2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$s$8$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO5uI!'5^@-!&K}@-0_D2%+%?%k!"0_%"%H%K!<>I!"0_3HD%!"0-AK(B($B$D$o$j(B)$B!"0`=L?U(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?Nd$(>I$N?M$G!"?)M_IT?6!"0_ItDdBZ46!"2l9g$KMQ$$$k!#(B
$B#1!K0_D25uI>u$rH<$&>l9g!#(B
$B#2!KJ"It$,Fpl9g!#(B

$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$B%+%s%-%g%&!D(B3.0g
033 $B%D%`%iBg2+24C0HiEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$*$&$\$?$s$T$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"2I!'7n7PIT=g!"7n7P:$Fq!"JXHk!"<&<@(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N=<l9g!#(B
$B#1!K7n7P:$Fq!"2aB?7n7P$J$I$N7n7P0[>o$N$"$k>l9g!#(B

$BF|6I%H%&%K%s!D(B4.0g,$BF|6I%\%?%s%T!D(B4.0g,$BF|6I%@%$%*%&!D(B2.0g,$B%H%&%,%7!D(B6.0g,$BL5?e%\%&%7%g%&!D(B1.8
034 $B%D%`%iGr8W2C?M;2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$S$c$C$3$+$K$s$8$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$N$I$N3i$-$H$[$F$j$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"BN$,$[$F$j!"8}3i$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KB?G"!"HiIfGBaZ46$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B:nMQ5!=x(B
$B!!!!8}3i$KBP$9$k:nMQ!J%i%C%H!K(B

$BF|6I%;%C%3%&!D(B15.0g,$BF|6I%A%b!D(B5.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%K%s%8%s!D(B1.5g,$B%3%&%Y%$!D(B8.0g
035 $B%D%`%i;M5U;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$.$c$/$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$N$"$k$b$N$G!"BgZ$H>.Z$H$NCf4V>ZI=$o$9$b$N$NI(B:$BC@G91j!"C@@P>I!"0_1j!"0_;@2aB?!"0_DYag!"I!%+%?%k!"5$4I;Y1j!"?@7P
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"6;OF6lK~!"J"D>6Z$NZ;5^$,$"$j!"%$%i%$%i!"ITL2!"M^$&$D46$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KJ"DK!"J"ItKDK~46!"F0X)$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93DYag:nMQ!J%i%C%H!K(B
$B#2!%4N!&C@F;>c32M^@):nMQ!J%i%C%H!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K93DYag:nMQ!J%i%C%H!K(B
$B!!!J#2!K3h@-;@AG>C5n:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K%W%m%H%s%]%s%W3h@-AK32:nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g
036 $B%D%`%iLZKIVaEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$b$/$\$&$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4i?'$,$5$($:!"31$r$H$b$J$&8F5[:$Fq$,$"$j!"?4B!2
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$,!"?4c]It$,$D$+$($F9E$/!"8F5[:$Fq!"Ibl9g$KMQ$$$k!#(B
$B#1!K8}3i!"G"NL8:>/$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B?4ITA4%b%G%k$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%\%&%$!D(B4.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g
037 $B%D%`%iH>2FGr[2E7KcEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$s$2$S$c$/$8$e$D$F$s$^$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_D25u
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?0_D25uI$G!";}B3@-$N$"$^$j7c$7$/$J$$F,DK!"F,=E46!"$a$^$$$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K0-?4!"SREG!"?)M_IT?6!"A4?H7qBU46$J$I$rH<$&>l9g!#(B
$B#2!KJ"It$,Fpl9g!#(B
$BF|6I%A%s%T!D(B3.0g,$BF|6I%O%s%2!D(B3.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%?%/%7%c!D(B1.5g,$BF|6I%K%s%8%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g,$B%F%s%^!D(B2.0g,$B%P%/%,!D(B2.0g,$B%+%s%-%g%&!D(B1.0g
038 $B%D%`%iEv5";M5U2C8bh%hP@8U*Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$7$.$c$/$+$4$7$e$f$7$g$&$-$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI!'$7$b$d$1!"F,DK!"2
$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$h$jNd$(>I$GBNl9g$KMQ$$$k!#(B
$B#1!KF,DK!"0-?4!"SREG$J$I$rH<$&>l9g!#(B
$B#2!K2e5-$N>I>u$rDh$9$k>l9g$K$bB?$/MQ$$$i$l$k!#(B

$BF|6I%?%$%=%&!D(B5.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%b%/%D%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%4%7%e%f!D(B2.0g,$BF|6I%5%$%7%s!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
039 $B%D%`%iNj7K[24EEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$g$&$1$$$8$e$D$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$a$^$$!"$U$i$D$-$,$"$j!"$^$?$OF0X)$,$"$jG"NL$,8:>/$9$k$b$N$NI!'?@7P
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"$a$^$$!"?HBNF0MI46!"$?$A$/$i$_$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KB)@Z$l!"?4X)P6?J!"F,DK!"$N$\$;!"G"NL8:>/$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k>l9g!#(B

$BF|6I%V%/%j%g%&!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g
040 $B%D%`%iCvNjEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BG"NL8:>/!">.JXFq!"8}3i$rAJ$($k$b$N$NI(B:$BG"F;1j!"?UB!1j!"?U@P>I!"NT1j!"GSG"DK!"7lG"!"9x0J2<$NIb
$B-"!V;HMQL\I8!a>Z!W(B
$BIQG"!";DG"46!"GSG"DK!"7lG"$J$I$NGSG">c32$N$"$k>l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%MxG":nMQ!J%i%C%H!K(B
$B#2!%7k@P7A@.M^@):nMQ!J%M%3!"%i%C%H!K(B
$B#3!%93?U1j:nMQ!J%i%C%H!K(B

$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$B%"%-%g%&!D(B3.0g,$B%+%C%;%-!D(B3.0g
041 $B%D%`%iJdCf1W5$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$[$A$e$&$($C$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B>C2=5!G=$,?j$(!";M;h7qBU46Cx$7$$5uI(B:$B2F$d$;!"IB8e$NBNNOA}6/!"7k3K>I!"?)M_IT?6!"0_2?HIT?o!"B?4@>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$,!"A4?H7qBU46!"?)M_IT?6$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K5uI$J$I$NK}@-<@45$G>e5->I>u$rDh$9$k>l9g!#(B
$B#2!K=Q8e!"IB8e!";:8e$J$I$G?jl9g!#(B
$B#3!K31SV!"HyG.!"Ep4@!"F0X)$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%IB8e$NBNNODc2<$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!%9bNp $B#3!%46KA$KBP$9$k:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!KGr7l5e$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!J#2!KLH1VD4@0:nMQ!J%i%C%H!"%^%&%9!"(Bin vitro$B!K(B
$B!!!J#3!K@:Ac$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%.!D(B4.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%K%s%8%s!D(B4.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%^!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g
043 $B%D%`%iO;7/;REr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$C$/$s$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_D2$N$*$A$,$D$+$(!"Hh$l$d$9$/!"IO7l@-$GI(B:$B0_1j!"0_%"%H%K!C2=ITNI!"?)M_IT?6!"0_DK!"SREG(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$,0_D25!G=$,Dc2<$7$F!"?)M_IT?6!"?4c]It$NKDK~46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"l9g!#(B
$B#2!KJ"JI$N6[D%$,l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B!L%R%H$G$N:nMQ!M(B
$B!!#1!%0_GS=PB%?J:nMQ(B
$B!!#2!%0_G4Kl7lN.NLA}2C:nMQ(B
$B!!#3!%0_G4KlEE0L:9!J(Bpotential difference$B!KDc2 $B!LF0J*$G$N:nMQ!M(B
$B!!#1!%>C2=4I1?F0P6?J:nMQ!J%$%L!K(B
$B!!#2!%0_E,1~@-CP4K$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!#3!%0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!K(B
$B!!#4!%0_G4Kl7lN.Dc2 $B!!#5!%0_;@!&%Z%W%7%s$NJ,HgM^@):nMQ!J%i%C%H!K(B
$B!!#6!%2CNp$KH<$&>.D2G4Kl$NJQ2=$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!#7!%:nMQ5!=x(B
$B!!!!!J#1!K0_E,1~@-CP4K$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!!!J#2!K0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B!!!!!J#3!K0_;@!&%Z%W%7%s$NJ,HgM^@):nMQ!J(Bin vitro$B!K(B
$B!!!!!J#4!K3h@-;@AG>C5n:nMQ!J(Bin vitro$B!K(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%K%s%8%s!D(B4.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g
045 $B%D%`%i7K;^Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO$,?j$($?$H$-$NIw
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$GF,DK!"H/G.!"0-46!"?HBNDK$J$I$,$"$j!"<+A3$K4@$N=P$d$9$$>l9g$KMQ$$$k!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
046 $B%D%`%i<7J*9_2 $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$A$b$D$3$&$+$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?HBN5uI(B:$B9b7l05$KH<$&?oH<>I>u(B($B$N$\$;!"8*$3$j!"<*$J$j!"F,=E(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBNI$KMQ$$$k!#(B
$B#1!K0WHhO+46!"2?H$NNd$(!"IQG"798~$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B7l059_2<:nMQ!J%i%C%H!K(B

$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%*%&%.!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%*%&%P%/!D(B2.0g,$B%A%g%&%H%&%3%&!D(B3.0g
047 $B%D%`%iD`F#;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$&$H$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BK}@-$KB3$/F,DK$GCfG/0J9_!"$^$?$O9b7l05$N798~$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$?CfG/0J9_$N?M$G!"K}@-$K7P2a$9$kF,DK!"8*$3$j!"$a$^$$$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KD+J}$"$k$$$O$a$6$a;~$KF,DK!"F,=E46$N$"$k$3$H$,B?$$!#(B
$B#2!K$N$\$;!"<*LD!"ITL2!"4c5e7kKl$N=<7l$J$I$rH<$&>l9g!#(B

$BF|6I%;%C%3%&!D(B5.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%O%s%2!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%A%g%&%H%&%3%&!D(B3.0g,$B%-%C%+!D(B2.0g
048 $B%D%`%i==A4BgJdEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$e$&$<$s$@$$$[$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIB8e$NBNNODc2
$B-"!V;HMQL\I8!a>Z!W(B
$BIB8e!"=Q8e$"$k$$$OK}@-<@45$J$I$G!"HhO+?jl9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"?)M_IT?6!"4i?'ITNI!"HiIf8OAg!"IO7l$J$I$rH<$&$3$H$,B?$$!#(B
$B#2!KEp4@!"8}Fb4%Ag46$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%IB8e$NBNNODc2<$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!% $B#3!%IO7l$KBP$9$k:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!!!!LH1VD4@0:nMQ(B
$B!!!!!!!J#1!K1U@-LH1V$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#2!K:YK&@-LH1V$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#3!K#N#K3h@-$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#4!K%^%/%m%U%!!<%83h@-$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#5!K%5%$%H%+%$%s;:@8$KBP$9$k:nMQ!J%^%&%9!"(Bin vitro$B!K(B

$BF|6I%*%&%.!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0,$BF|6I%H%&%-!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g
050 $B%D%`%i7U3)O"fKEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$,$$$l$s$.$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BC_G?>I!"K}@-I!1j!"K}@-Y(Em1j!"$K$-$S(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G!"HiIf$N?'$,@u9u$/!"I{I!9P!"Y(Em$J$I$K1j>I$r5/$3$7$d$9$$>l9g$KMQ$$$k!#(B
$B#1!K4iLL!"0v9"!">e5$F;$J$I$KH/$9$kK}@-$N1j>I@-=t<@45!#(B
$B-#!VLt8z!&LtM}!W(B
$B#1!%936]:nMQ!J(Bin vitro$B!K(B
$B#2!%:nMQ5!=x(B
$B!!!J#1!K:Bal$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$BF|6I%*%&%4%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%-%-%g%&!D(B1.5g,$BF|6I%-%8%D!D(B1.5g,$BF|6I%1%$%,%$!D(B1.5g,$BF|6I%5%$%3!D(B1.5g,$BF|6I%5%s%7%7!D(B1.5g,$BF|6I%8%*%&!D(B1.5g,$BF|6I%7%c%/%d%/!D(B1.5g,$BF|6I%;%s%-%e%&!D(B1.5g,$BF|6I%H%&%-!D(B1.5g,$BF|6I%O%C%+!D(B1.5g,$BF|6I%S%c%/%7!D(B1.5g,$BF|6I%\%&%U%&!D(B1.5g,$BF|6I%l%s%.%g%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g
051 $B%D%`%i=aD2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$e$s$A$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$NCP4K@-$^$?$Oa[Z;@-JXHk$KMQ$$$k!#(B
$B#1!KO7?M$"$k$$$O0_D25!G=$NDc2<$7$??M$NJXHk!#(B
$B#2!KHiIf8OAg!"J"JICP4K$7J52t$,?(CN$5$l$k>l9g!#(B

$BF|6I%8%*%&!D(B6.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%-%g%&%K%s!D(B2.0g,$BF|6I%3%&%\%/!D(B2.0g,$BF|6I%@%$%*%&!D(B2.0g,$BF|6I%H%&%K%s!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%^%7%K%s!D(B2.0g
052 $B%D%`%i0Ugo?NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$h$/$$$K$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"6ZFyDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"Hf3SE*K}@-$K7P2a$9$k;M;h$N4X@a!"6ZFy$NaVDK!"l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B931j>I:nMQ!J%i%C%H!K(B

$BF|6I%h%/%$%K%s!D(B8.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g
053 $B%D%`%iAB7P3h7lEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$=$1$$$+$C$1$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"?@7PDK!"9xDK!"6ZFyDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"9xIt$h$j2<;h$K$+$1$F$N6ZFy!"4X@a!"?@7P$,DK$`>l9g$KMQ$$$k!#(B
$B#1!KNd$($K$h$jA}0-$9$k$3$H$,B?$$!#(B
$B#2!K1w7l$rH<$&>l9g!#(B
$BF|6I%7%c%/%d%/!D(B2.5g,$BF|6I%8%*%&!D(B2.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%=%&%8%e%D!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%H%&%K%s!D(B2.0g,$BF|6I%V%/%j%g%&!D(B2.0g,$BF|6I%4%7%D!D(B1.5g,$BF|6I%A%s%T!D(B1.5g,$BF|6I%\%&%$!D(B1.5g,$BF|6I%\%&%U%&!D(B1.5g,$BF|6I%j%e%&%?%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%S%c%/%7!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g,$B%$%l%$%;%s!D(B1.5g,$B%-%g%&%+%D!D(B1.5g
054 $B%D%`%iM^4N;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$h$/$+$s$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$B?@7P>I!"ITL2>I!">.;yLk$J$-!">.;yaQ>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?@7P2aIR$G6=J3$7$d$9$/!"E\$j$d$9$$!"%$%i%$%i$9$k!"L2$l$J$$$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K$*$A$D$-$,$J$$!"$R$-$D$1!"Lk5c$-$J$I$N$"$k>.;y!#(B
$B#2!K4cb[a[Z;$dl9g!#(B
$B#3!KJ"D>6Z$N6[D%$7$F$$$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B93IT0B:nMQ!J%^%&%9!K(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%A%g%&%H%&%3%&!D(B3.0g
055 $B%D%`%iKc0I4E@PEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$-$g$&$+$s$;$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B>.;y$<$s$=$/!"5$4I;Y$<$s$=$/(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"31SV$,6/$/!"8}3i!"<+A3H/4@!"G.46$J$I$,$"$j!"SCLD!"8F5[:$Fq$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KG4cG$G$d$d@Z$l$K$/$$ab$rH<$&>l9g!#(B
$B#2!K>.;y$KE,MQ$5$l$k$3$H$,B?$$!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!<:nMQ!J%i%C%H!K(B
$B#2!%:nMQ5!=x(B
$B!!!!93%"%l%k%.!<:nMQ!J(Bin vitro$B!K(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g
056 $B%D%`%i8^NT;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$j$s$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BIQG"!"GSG"DK!";DG"46(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$NK}@-$K7P2a$7$?G"O)1j>I$G!"IQG"!"!";DG"46!"GSG"DK$J$I$N$"$k>l9g$KMQ$$$k!#(B
$BF|6I%V%/%j%g%&!D(B6.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%b%/%D%&!D(B3.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$B%+%C%;%-!D(B3.0g
057 $B%D%`%i29@60{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$&$s$;$$$$$s(B
$B-!!V8zG=!&8z2L!W(B
$BHiIf$N?'$D$d$,0-$/!"$N$\$;$k$b$N$KMQ$$$k(B:$B7n7PIT=g!"7n7P:$Fq!"7l$NF;>I!"99G/4|=}32!"?@7P>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"IT0B!"ITL2!"$N$\$;$J$I$N@:?@?@7P>I>u$,$"$j!"=P7l798~$rH<$&>l9g$KMQ$$$k!#(B
$B#1!KHiIf$O2+3l?'$rDh$7!"8OAg$7$F$$$k$3$H$,B?$$!#(B
$B#2!K2<7l$N$"$k>l9g$d!"IX?M$G$O;R5\=P7l$d7n7P2aB?$G=P7l$NB?$$>l9g!#(B
$B#3!KH/G.!"G.46$,$"$C$FGBaZ46$,6/$/!"J,HgJ*$N>/$J$$HiIf>I>u$rH<$&>l9g!#(B
$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%4%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%5%s%7%7!D(B1.5g
058 $B%D%`%i@6>eKIIwEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$8$g$&$\$&$U$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$K$-$S(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$N!"4iLL$*$h$SF,It$NH/?>$GH/@V$N6/$$$b$N!"2=G?$7$F$$$k$b$N$J$I$KMQ$$$k!#(B
$B#1!K@DG/
$B-#!VLt8z!&LtM}!W(B
$B#1!%936]:nMQ!J(Bin vitro$B!K(B
$B#2!%:nMQ5!=x(B
$B!!!!93%j%Q!<%<:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%-%-%g%&!D(B2.5g,$BF|6I%5%s%7%7!D(B2.5g,$BF|6I%;%s%-%e%&!D(B2.5g,$BF|6I%O%^%\%&%U%&!D(B2.5g,$BF|6I%S%c%/%7!D(B2.5g,$BF|6I%l%s%.%g%&!D(B2.5g,$BF|6I%*%&%l%s!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%-%8%D!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$BF|6I%O%C%+!D(B1.0g
059 $B%D%`%i<#F,al0lJ}(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$B$E$=$&$$$C$]$&(B
$B-!!V8zG=!&8z2L!W(B
$B<>?>!"$/$5!"F}MD;y$N<>?>(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$N4iLL!"F,It$J$I$N<>?>$G!"J,HgJ*!"$S$i$s!"aPHi$J$IG'$a!"GBaZ46$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K>.;y$N<>?>$KMQ$$$i$l$k$3$H$,B?$$!#(B
$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%l%s%.%g%&!D(B3.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$BF|6I%3%&%+!D(B1.0g,$BF|6I%@%$%*%&!D(B0.5g,$B%K%s%I%&!D(B2.0g
060 $B%D%`%i7K;^2CgiLtEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$7$c$/$d$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJ"ItKDK~46$N$"$kI(B:$B$7$V$jJ"!"J"DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"J"ItKDK~$7!"J"DK$,$"$j!"N"5^8e=E$rH<$&2l9g$KMQ$$$k!#(B
$BK\J}$O7K;^2CgiLtBg2+Er$h$j$bN"5^8e=E$"$k$$$OJXHk$,7ZEY$N>l9g$K$h$$!#(B
$B#1!KJX0U$r:E$9$,!"2w$/GSJX$7$J$$>l9g!#(B
$B#2!K2<:^I~MQ8e$NJ"DK!#(B
$B#3!K3+J"=Q8e$KJX$,2wDL$7$J$$>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%;__C:nMQ!J%^%&%9!K(B
$B#2!%D24IM"AwG=$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
061 $B%D%`%iEm3K>55$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$+$/$8$g$&$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"$N$\$;$FJXHk$7$,$A$J$b$N$NI(B:$B7n7PIT=g!"7n7P:$Fq>I!"7n7P;~$d;:8e$N@:?@IT0B!"9xDK!"JXHk!"9b7l05$N?oH<>I>u(B($BF,DK!"$a$^$$!"8*$3$j(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!"BNNO$N=<.J"5^7k!K!"JXHk$7!"$N$\$;$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KF,DK!"$a$^$$!"ITL2!"IT0B!"I>u$rH<$&>l9g!#(B
$B#2!K7n7PIT=g!"7n7P:$Fq$J$I$N$"$kIX?M!#(B

$BF|6I%H%&%K%s!D(B5.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%@%$%*%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g,$BL5?e%\%&%7%g%&!D(B0.9g
062 $B%D%`%iKIIwDL@;;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$\$&$U$&$D$&$7$g$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BJ"It$KHi2<;iKC$,B?$/!"JXHk$,$A$J$b$N$NI(B:$B9b7l05$N?oH<>I>u(B($B$I$&$-!"8*$3$j!"$N$\$;(B)$B!"HnK~>I!"$`$/$_!"JXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$N=<l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%HnK~$KBP$9$k:nMQ!J%^%&%9!K(B
$B#2!%:nMQ5!=x(B
$B!!!!!!3l?';iKCAH?%$N3h@-2=:nMQ!J%^%&%9!K(B
$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%;%C%3%&!D(B2.0g,$BF|6I%S%c%/%8%e%D!D(B2.0g,$BF|6I%@%$%*%&!D(B1.5g,$BF|6I%1%$%,%$!D(B1.2g,$BF|6I%5%s%7%7!D(B1.2g,$BF|6I%7%c%/%d%/!D(B1.2g,$BF|6I%;%s%-%e%&!D(B1.2g,$BF|6I%H%&%-!D(B1.2g,$BF|6I%O%C%+!D(B1.2g,$BF|6I%\%&%U%&!D(B1.2g,$BF|6I%^%*%&!D(B1.2g,$BF|6I%l%s%.%g%&!D(B1.2g,$BF|6I%7%g%&%-%g%&!D(B0.3g,$B%+%C%;%-!D(B3.0g,$BL5?e%\%&%7%g%&!D(B0.7g
063 $B%D%`%i8^@Q;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$7$c$/$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BK}@-$K7P2a$7!">I>u$N7c$7$/$J$$I(B:$B0_D21j!"9xDK!"?@7PDK!"4X@aDK!"7n7PDK!"F,DK!"Nd$(>I!"99G/4|=}32!"46KA(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G!"4(Nd$d<>5$$K?/$5$l$F!"9xDK!"2l9g$KMQ$$$k!#(B
$B#1!KIO7l5$L#$G!">eH>?H$,G.$72?H$NNd$($k>l9g!#(B
$B#2!K7n7PIT=g$d7n7P:$Fq$J$I$N$"$kIX?M!#(B
$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%O%s%2!D(B2.0g,$BF|6I%V%/%j%g%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%-%-%g%&!D(B1.0g,$BF|6I%-%8%D!D(B1.0g,$BF|6I%1%$%R!D(B1.0g,$BF|6I%3%&%\%/!D(B1.0g,$BF|6I%7%c%/%d%/!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%;%s%-%e%&!D(B1.0g,$BF|6I%?%$%=%&!D(B1.0g,$BF|6I%S%c%/%7!D(B1.0g,$BF|6I%^%*%&!D(B1.0g
064 $B%D%`%i_U4EApEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$c$+$s$>$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO$,$*$H$m$($F!"Hh$l$d$9$$$b$N$NF0X)!"B)@Z$l(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"F0X)!"B)@Z$l$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KHiIf$N8OAg!"0WHhO+46!"l9g!#(B
$BF|6I%8%*%&!D(B6.0g,$BF|6I%P%/%b%s%I%&!D(B6.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%^%7%K%s!D(B3.0g,$B%7%c%+%s%>%&!D(B3.0g,$B%"%-%g%&!D(B2.0g
065 $B%D%`%i5"g#Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$-$R$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$BIO7l!"ITL2>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNI>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K2<7l!"EG7l$J$I$rH<$&>l9g!#(B
$B#2!KEp4@!"A4?H7qBU46!"?)M_IT?6$J$I$rH<$&>l9g!#(B
$BF|6I%*%&%.!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%s%8!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%b%C%3%&!D(B1.0g,$B%5%s%=%&%K%s!D(B3.0g,$B%j%e%&%,%s%K%/!D(B3.0g
066 $B%D%`%i;2AI0{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$s$=$$$s(B
$B-!!V8zG=!&8z2L!W(B
$B46KA!"$;$-(B

$B-"!V;HMQL\I8!a>Z!W(B
$B0_D25ul9g$KMQ$$$k!#(B
$B#1!KF,DK!"H/G.!"31SV!"S=ab$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$N$D$+$(!"0-?4!"SREG$J$I$N$"$k>l9g!#(B
$BF|6I%O%s%2!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%C%3%s!D(B2.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%?%$%=%&!D(B1.5g,$BF|6I%K%s%8%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%-%8%D!D(B1.0g,$BF|6I%=%h%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g,$B%<%s%3!D(B2.0g
067 $B%D%`%i=w?@;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$g$7$s$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$N$\$;$H$a$^$$$N$"$k$b$N$NI(B:$B;:A0;:8e$N?@7P>I!"7n7PIT=g!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"$N$\$;$H$a$^$$$,$"$j!"IT0B!"F0X)!"@:?@IT0B!"ITL2!"F,DK$J$I$N@:?@?@7P>I>u$,$"$k>l9g$KMQ$$$k!#(B
$B#1!KK}@-$GB?:L$J>I>u$rAJ$($k>l9g!#(B
$B#2!K@-<~4|$KH<$C$F$"$k$$$O;:A0;:8e$K>I>u$rAJ$($k>l9g!#(B
$BF|6I%3%&%V%7!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%S%s%m%&%8!D(B2.0g,$BF|6I%*%&%l%s!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%A%g%&%8!D(B1.0g,$BF|6I%b%C%3%&!D(B1.0g
068 $B%D%`%igiLt4EApEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$c$/$d$/$+$s$>$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5^7c$K$*$3$k6ZFy$N$1$$$l$s$rH<$&aVDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$B5^7c$K5/$3$k6ZFy!J$*$b$K2<;h!K$Na[Z;@-aVDK$J$i$S$KJ"ItaMDK$rAJ$($k>l9g$KMQ$$$k!#F\I~$"$k$$$OB>$N=hJ}$HJ;MQ$5$l$k$3$H$,B?$$!#(B

$B-#!VLt8z!&LtM}!W(B
$Ba[=L%b%G%k$K$*$1$k6ZHhO+M^@):nMQ!J%i%C%H!K(B

$BF|6I%+%s%>%&!D(B6.0g,$BF|6I%7%c%/%d%/!D(B6.0g
069 $B%D%`%ih*Nj0{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$V$/$j$g$&$$$s(B
$B-!!V8zG=!&8z2L!W(B
$BEG$-$1$d6;$d$1$,$"$jG"NL$,8:>/$9$k$b$N$NI(B:$B0_1j!"0_%"%H%K!
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$G!"0_Fb$K?eJ,$,DdBZ$7$F$$$k$?$a!"0_ItKDK~46!"?4c]It?6?e2;!"6;$d$1!"0-?4$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K?)M_IT?6!"?4X)P6?J!"G"Mx8:>/$J$I$rH<$&>l9g!#(B

$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%-%8%D!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
070 $B%D%`%i9aAI;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$3$&$=$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B0_D25u
$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$h$j0_D25u $B#1!K?)M_IT?6$d7ZEY$N0-4(!"H/G.$J$I$rH<$&>l9g!#(B
$B#2!K3k:,Er$dKc2+Er$J$I$NKc2+:^$G$O?)M_IT?6$r5/$3$9>l9g!#(B
$BF|6I%3%&%V%7!D(B4.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
071 $B%D%`%i;MJ*Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$b$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHiIf$,8OAg$7!"?'$D$d$N0-$$BNc32$N$J$$?M$NI(B:$B;:8e$"$k$$$ON.;:8e$NHhO+2sI|!"7n7PIT=g!"Nd$(>I!"$7$b$d$1!"$7$_!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"l9g$KMQ$$$k!#(B
$B#1!K7n7PIT=g!"<+N'?@7P<:D4>I>u$J$I$rH<$&IX?M!#(B
$B#2!KJ"ItFpl9g!#(B

$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g
072 $B%D%`%i4EG~Bg\'Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$s$P$/$?$$$=$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BLk5c$-!"$R$-$D$1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"@:?@6=J3$,$O$J$O$@$7$/!"IT0B!"ITL2!"$R$-$D$1$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KJ"D>6Z$NZ;5^$7$F$$$k>l9g!#(B

$BF|6I%?%$%=%&!D(B6.0g,$BF|6I%+%s%>%&!D(B5.0g,$B%7%g%&%P%/!D(B20.0g
073 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B31!"31$K$h$k6;DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"6/$$31$,=P$F!"ab$,@Z$l$K$/$/!"6;DK$9$k>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$h$j5(O>It$K$+$1$F6lK~46$rAJ$(!"Dq93!&05DK$NG'$a$i$l$k>l9g!#!J6;OF6lK~!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%+%m%K%s!D(B3.0g
074 $B%D%`%iD40_>55$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$&$$$8$g$&$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$NJXHk$KMQ$$$k!#(B
$B#1!KJ"ItKDK~46$,6/$/!"J"DK$7!"JXHk$9$k>l9g!#(B

$BF|6I%@%$%*%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BL5?e%\%&%7%g%&!D(B0.5g
075 $B%D%`%i;M7/;REr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$/$s$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$d$;$F4i?'$,0-$/$F!"?)M_$,$J$/!"$D$+$l$d$9$$$b$N$NI(B:$B0_D25u
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$,!"0_D25!G=$,Dc2<$7$F!"?)M_IT?6!"?4c]It$NKDK~46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"l9g!#(B
$B#2!KJ"JI$N6[D%$,l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%DYag$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%@)EG:nMQ!J%$%L!K(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%K%s%8%s!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%?%$%=%&!D(B1.0g
076 $B%D%`%iN5C@_C4NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$e$&$?$s$7$c$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"2I(B:$BGSG"DK!";DG"46!"G"$NBy$j!"$3$7$1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$GHgG"4o!"@8?#4oEy$N1j>I$KH<$C$FGSG"DK!"IQG"!"BS2<$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K5^@-$"$k$$$OK}@-$NHgG"4o!&@8?#4o$N1j>I@-<@45!#(B
$B#2!K1"ItGBaZ46$rH<$&>l9g!#(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%H%&%-!D(B5.0g,$BF|6I%b%/%D%&%&!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%5%s%7%7!D(B1.0g,$BF|6I%j%e%&%?%s!D(B1.0g
077 $B%D%`%i5]5"g1ghEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$-$e$&$-$-$g$&$,$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B<&=P7l(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G<&=P7l!"2<7l$J$I$,$"$k>l9g$KMQ$$$k!#(B
$B#1!K=P7l$,D9$S$$$F!"IO7l$d$a$^$$!"l9g!#(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$B%,%$%h%&!D(B3.0g,$B%"%-%g%&!D(B3.0g
078 $B%D%`%iKc0I0U4EEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$-$g$&$h$/$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"?@7PDK!"6ZFyDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$,!"=t4X@a$d6ZFy$,l9g$KMQ$$$k!#(B
$B#1!Kl9g!#(B

$BF|6I%h%/%$%K%s!D(B10.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%-%g%&%K%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0
079 $B%D%`%iJ?0_;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$X$$$$$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B0_$,$b$?$l$F>C2=ITNI$N798~$N$"$kI(B:$B5^!&K}@-0_%+%?%k!"0_%"%H%K!C2=ITNI!"?)M_IT?6(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$,!">C2=>c32$r$-$?$7$F?4c]ItIT2w46!"J"ItKDK~46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K?)M_IT?6!"?)8e$NJ"LD!"2l9g!#(B
$B#2!K2a?)$J$I$K$h$k5^@-0_D2>c32!#(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g
080 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$;$$$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$+$s$N798~$N6/$$798~$N$"$k>.;y$NI(B:$B?@7P>I!"K}@-Y(EmA#1j!"<>?>(B

$B-"!V;HMQL\I8!a>Z!W(B
$BA#IBI!"l9g$KMQ$$$k!#(B
$B#1!K>.;y$KMQ$$$i$l$k$3$H$,B?$$!#(B
$B#2!KaQ$,6/$/!"ITL2!"Lk5c$-$J$I$N$"$k>l9g!#(B
$B#3!KN>J"D>6Z$N6[D%$d!"5(O>2l9g!#(B
$B-#!VLt8z!&LtM}!W(B
$B93%"%l%k%.!<:nMQ!J%^%&%9!K(B

$BF|6I%5%$%3!D(B2.0g,$BF|6I%*%&%4%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%+%m%3%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%-%-%g%&!D(B1.5g,$BF|6I%5%s%7%7!D(B1.5g,$BF|6I%8%*%&!D(B1.5g,$BF|6I%7%c%/%d%/!D(B1.5g,$BF|6I%;%s%-%e%&!D(B1.5g,$BF|6I%H%&%-!D(B1.5g,$BF|6I%O%C%+!D(B1.5g,$BF|6I%l%s%.%g%&!D(B1.5g,$B%4%\%&%7!D(B1.5g
081 $B%D%`%iFsDDEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$A$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0-?4!"SREG(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G0-?4!"SREG!"0_ItIT2w46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K$a$^$$!"F0X)!"F,DK$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k$3$H$,B?$$!#(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%A%s%T!D(B4.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
082 $B%D%`%i7K;^?M;2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$K$s$8$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_D2$NI(B:$BF,DK!"F0X)!"K}@-0_D21j!"0_%"%H%K!<(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"?)M_IT?6!"0-?4!"SREG!"0_ItDdBZ46!"2I>u$KF,DK!"F,=E!"?4X)P6?J$J$I$rH<$&>l9g$KMQ$$$k!#(B
$B#1!KNd$(>I$G4i?'0-$/Hh$l$d$9$$>l9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$B%+%s%-%g%&!D(B2.0g
083 $B%D%`%iM^4N;62CDDHiH>2F(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$h$/$+$s$5$s$+$A$s$T$O$s$2(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$B?@7P>I!"ITL2>I!">.;yLk$J$-!">.;yaQ>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"?@7P2aIR$G6=J3$7$d$9$/!"E\$j$d$9$$!"%$%i%$%i$9$k!"L2$l$J$$$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KM^4N;6$KHf$Y!"$h$jBNNO$,Dc2<$7$F>I>u$,$h$jK}@-2=$7$F$$$k$3$H$,B?$$!#(B
$B#2!K$*$A$D$-$,$J$/!"$R$-$D$1!"Lk5c$-$J$I$N$"$k>.;y!#(B
$B#3!K4cb[a[Z;$dl9g!#(B
$B#4!KJ"D>6Z$N6[D%$7$F$$$k>l9g!#(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%A%g%&%H%&%3%&!D(B3.0g
084 $B%D%`%iBg2+4EApEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$*$&$+$s$>$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$B>o=,JXHk$K9-$/MQ$$$k!#(B

$BF|6I%@%$%*%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g
085 $B%D%`%i?@HkEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$s$T$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B>.;y$<$s$=$/!"5$4I;Y$<$s$=$/!"5$4I;Y1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"8F5[:$Fq$rl9g$KMQ$$$k!#(B
$B#1!KSCB)!"31SV$rH<$&$,S=ab$N>/$J$$>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%931j>I:nMQ!J%i%C%H!K(B
$B#2!%:nMQ5!=x(B
$B!!!J#1!K%m%$%3%H%j%(%s!J#L#T!K;:@8AK32:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B

$BF|6I%^%*%&!D(B5.0g,$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%=%h%&!D(B1.5g
086 $B%D%`%iEv5"0{;R(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$$$s$7(B
$B-!!V8zG=!&8z2L!W(B
$BNd$(>I$N$b$N$NI!'K}@-<>?>(B($BJ,HgJ*$N>/$J$$$b$N(B)$B!"$+$f$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$NHiIf<@45$G!"GBaZ$r/$J$$>l9g$KMQ$$$k!#(B
$B#1!KHiIf$,4%Ag$7$F<>=a$7$F$$$J$$>l9g!#(B
$B#2!KO7?M$KE,MQ$5$l$k$3$H$,B?$$!#(B

$BF|6I%H%&%-!D(B5.0g,$BF|6I%8%*%&!D(B4.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%\%&%U%&!D(B3.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%1%$%,%$!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$B%7%D%j%7!D(B3.0g,$B%+%7%e%&!D(B2.0g
087 $B%D%`%iO;L#4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$m$/$_$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BHh$l$d$9$/$FG"NL8:>/$^$?$OB?G"$G!";~$K8}3i$N$"$k$b$N$NI(B:$BGSG":$Fq!"IQG"!"$`$/$_!"$+$f$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"9xDK$*$h$S2<;h$NC&NO46!"$7$S$l$J$I$,$"$j!"G"0UIQ?t!"GSG";~0cOB46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KH,L#CO2+4]!"5ml9g!#(B
$B#2!K>eJ"It$KHf$Y$F2l9g!#(B
$B#3!KHhO+7qBU46!"J"DK$J$I$rH<$&>l9g!#(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%5%s%7%e%f!D(B3.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B3.0g
088 $B%D%`%iFs[2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$8$e$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B8^==8*(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"8*$d>eOS$,DK$`>l9g$KMQ$$$k!#(B
$BF|6I%O%s%2!D(B4.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%3%&%V%7!D(B2.5g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%S%c%/%8%e%D!D(B2.5g,$BF|6I%V%/%j%g%&!D(B2.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%$%l%$%;%s!D(B2.5g,$B%F%s%J%s%7%g%&!D(B2.5g,$B%o%-%g%&%+%D!D(B2.5g
089 $B%D%`%i<#BGKP0lJ}(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$@$\$/$$$C$]$&(B
$B-!!V8zG=!&8z2L!W(B
$BBGKP$K$h$k$O$l5Z$SDK$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBGKP!"G1:CEy$G!"45It$,l9g$KMQ$$$k!#(B
$BF|6I%1%$%R!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%;%s%3%D!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%@%$%*%&!D(B1.0g,$BF|6I%A%g%&%8!D(B1.0g,$B%\%/%=%/!D(B3.0g
090 $B%D%`%i@6GYEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$O$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$Bab$NB?$/=P$k31(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"G4cG$G@Z$l$K$/$$ab$,B?$/31SV$,A+1d2=$7$?>l9g$KMQ$$$k!#(B
$B#1!K>e5->I>u$,D9$S$$$F0v9"DK!"SN@l9g!#(B
$B#2!KK}@-2=$7$?8F5[4o<@45$Gab$NB?$/=P$k31!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%5nab:nMQ!J%&%5%.!"%O%H!"(Bin vitro$B!K(B
$B#2!%:nMQ5!=x(B
$B!!!J#1!KG41U@~LSM"Aw7O$KBP$9$k:nMQ!J%&%5%.!"(Bin vitro$B!K(B
$B!!!J#2!K3h@-;@AG!"%1%_%+%k%a%G%#%(!<%?!<$KBP$9$k:nMQ(B
$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J(Bin vitro$B!K(B

$BF|6I%H%&%-!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%-%g%&%K%s!D(B2.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%=%&%O%/%R!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%4%_%7!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%A%/%8%g!D(B2.0g,$B%F%s%b%s%I%&!D(B2.0g,$B%P%$%b!D(B2.0g
091 $B%D%`%iC]G!29C@Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$/$8$g$&$s$?$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B%$%s%U%k%(%s%6!"Iw
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"46KA$J$I$GH/G.$,D9$S$-!"$"$k$$$O2rG.8e!"31$,=P$Fab$,B?$/!"ITL2$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K@:?@IT0B!"?4X)P6?J$J$I$rH<$&>l9g!#(B
$B#2!K5(O>2l9g!J6;OF6lK~!K(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%3%&%V%7!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%*%&%l%s!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%K%s%8%s!D(B1.0g,$B%A%/%8%g!D(B3.0g
092 $B%D%`%i<"1";jJuEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$$$s$7$[$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5u
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$,Dc2<$7$??M$NK}@-$K7P2a$7$?31SV$KMQ$$$k!#(B
$B#1!KHf3SE*@Z$l$d$9$$ab$G!"NL$N$5$[$IB?$/$J$$>l9g!#(B
$B#2!K?)M_IT?6!"A4?H7qBU46!"Ep4@$J$I$rH<$&>l9g!#(B
$B#3!K8F5[4o<@45$,D9$S$$$?>l9g$N$;$-!&$?$s!#(B
$BF|6I%3%&%V%7!D(B3.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%A%b!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%O%C%+!D(B1.0g,$B%8%C%3%T!D(B3.0g,$B%P%$%b!D(B2.0g
093 $B%D%`%i<"1"9_2PEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$$$s$3$&$+$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$N$I$K$&$k$*$$$,$J$/ab$N=P$J$/$F31$3$`$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNODc2<$7$??M$G!"HiIf$N?'$,@u9u$/!"31SV!"G4cG$G@Z$l$K$/$$ab$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KMl9g!#(B
$B#2!KO7?M$d5ul9g!#(B
$B#3!K8F5[4o<@45$,D9$S$$$?>l9g!#(B

$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%8%*%&!D(B2.5g,$BF|6I%7%c%/%d%/!D(B2.5g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%H%&%-!D(B2.5g,$BF|6I%P%/%b%s%I%&!D(B2.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%A%b!D(B1.5g,$B%F%s%b%s%I%&!D(B2.5g
095 $B%D%`%i8^8WEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$3$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$;$-!"5$4I;Y$<$s$=$/(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"SCLD!"7c$7$$31SV$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K0-46!"H/G.$O$J$/!"<+A3H/4@!"8}3i$rAJ$($k>l9g!#(B
$B#2!K>.;y$KIQMQ$5$l$k!#(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%=%&%O%/%R!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g
096 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$\$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5$J,$,$U$5$$$G!"0v9"!"?)F;It$K0[J*46$,$"$j!";~$KF0X)!"$a$^$$!"SR5$$J$I$rH<$&I(B:$B>.;y$<$s$=$/!"5$4I;Y$<$s$=$/!"5$4I;Y1j!"$;$-!"IT0B?@7P>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"7ZEY$N6;OF6lK~!"?4c]It$NKDK~46$,$"$j!"31SV!"SCLD!"@:?@IT0B!"M^$&$D798~!"?)M_IT?6!"A4?H7qBU46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%931j>I:nMQ!J%b%k%b%C%H!"(Bin vitro$B!K(B
$B#2!%5$F;G4Kl@~LSM"Aw$N2~A1:nMQ!J(Bin vitro$B!K(B
$B#3!%93IT0B:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!K%1%_%+%k%a%G%#%(!<%?!<$N;:@8!&M7N%M^@):nMQ!J(Bin vitro$B!!!!!!!!!!!K(B
$B!!!J#2!K#I#g#E;:@8M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K%5%$%H%+%$%s;:@8$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#4!K9%;@5e$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#5!K#N#O;:@8$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#6!K@\CeJ,;RH/8=M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#7!K%9%F%m%$%I
$BF|6I%5%$%3!D(B7.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
097 $B%D%`%iBgKIIwEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$\$&$U$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@a$,$O$l$FDK$_!"Kcac!"6/D>$7$F6~?-$7$,$?$$$b$N$NI(B:$B2<;h$NK}@-4X@a%j%&%^%A!"K}@-4X@a1j!"DKIw(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"4i?'$,0-$/!"4X@a$Nc32$J$I$,$"$j!"0lHL$K$3$l$i$N>I>u$,K}@-$K7P2a$7$?>l9g$KMQ$$$i$l$k!#(B
$BF|6I%*%&%.!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%\%&%U%&!D(B3.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%4%7%D!D(B1.5g,$BF|6I%?%$%=%&!D(B1.5g,$BF|6I%K%s%8%s!D(B1.5g,$B%-%g%&%+%D!D(B1.5g,$B%H%A%e%&!D(B3.0g,$B%+%s%-%g%&!D(B1.0g,$B=$<#%V%7Kv!D(B1.0g
098 $B%D%`%i2+fM7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$&$.$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?HBN5uI(B:$B5u
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$G!"HhO+7qBU46$,Cx$7$/!"Ep4@$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KJ"DK!"?)M_IT?6!"B)@Z$l$J$I$rH<$&>l9g!#(B
$B#2!KH/?>!"$S$i$s$J$I$NHiIf>I>u$rH<$&>l9g!#(B
$B#3!KAO=}<#L~$NA+1d2=$dK}@-2=G?Ac$N$"$k>l9g!#(B
$B#4!KJ"It$OJ"JI$,Gv$/J"D>6Z$,6[D%$7$F$$$k>l9g!#(B

$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%*%&%.!D(B4.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
099 $B%D%`%i>.7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNI(B:$B>.;y5u.;yLkG">I!"Lk$J$-(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBN6Z$N6[D%$9$k>l9g$KMQ$$$k!#(B
$B#1!KJ"DK$rH<$&>l9g!#(B
$B#2!K?4X)P6?J!"Ep4@!";M;h7qBU46$J$I$rH<$&>l9g!#(B
$B#3!K5u
$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
100 $B%D%`%iBg7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJ"$,Nd$($FDK$_!"J"ItKDK~46$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$,Dc2<$7$??M$G;M;h$dJ"It$,Nd$(!"J"DK!"J"ItKDK~!"8]D2$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KJ"JI$,$&$9$/Fpl9g!#(B
$B#2!KNd$($K$h$j>I>u$N0-2=$9$k>l9g!#(B
$B#3!K3+J"=Q8e$ND24IDL2a>c32$KH<$&J"DK!"J"ItKDK~46!#(B

$B-#!VLt8z!&LtM}!W(B
$B!L%R%H$G$N:nMQ!M(B
$B!!#1!%>C2=4I1?F0B%?J:nMQ(B
$B!!#2!%>C2=4I%[%k%b%s$KBP$9$k:nMQ(B
$B!LF0J*$G$N:nMQ!M(B
$B!!#1!%>C2=4I1?F0B%?J:nMQ!J%$%L!K(B
$B!!#2!%%$%l%&%92~A1:nMQ!J%i%C%H!"%^%&%9!K(B
$B!!#3!%>C2=4I5!G=0[>o2~A1:nMQ!J%i%C%H!K(B
$B!!#4!%:nMQ5!=x(B
$B!!!!!J#1!K>C2=4I1?F0B%?J:nMQ!J(Bin vitro$B!K(B
$B!!!!!J#2!K%7%/%m%*%-%7%2%J!<% $B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J(Bin vitro$B!K(B

$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%5%s%7%g%&!D(B2.0g,$B%+%s%-%g%&!D(B5.0g
101 $B%D%`%i>#Kc3k:,Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$^$+$C$3$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B46KA$N=i4|!"HiIf1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$B46KA$N=i4|!"HiIf1j$KMQ$$$k!#(B
$B#1!KF,DK!"H/G.!"0-46$J$I$rH<$&>l9g!#(B
$B#2!KKc?>$J$IH/?>$rH<$&>l9g!#(B

$BF|6I%+%C%3%s!D(B5.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%7%g%&%^!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B0.5g
102 $B%D%`%iEv5"Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BGXCf$K4(Nd$r3P$(!"J"ItKDK~46$dJ"DK$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BNd$(>I$G7l?'$N0-$$Hf3SE*BNNO$NDc2<$7$??M$G!"6;J"It(B
$B$h$jGXIt$K$+$1$F!"aVDK$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K69?4>IMM!"O>4V?@7PDKMM$NDK$_$,$"$k>l9g!#(B
$BF|6I%H%&%-!D(B5.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%5%s%7%g%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$B%+%s%-%g%&!D(B1.5g
103 $B%D%`%i;@\'?NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$s$=$&$K$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?4?H$,$D$+$l
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$G!"?4?H$H$b$KHhO+$7$F!"ITL2$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KK}@-<@4545l9g!#(B
$B#2!K@:?@IT0B!"?@7P2aIR$J$I$rH<$&>l9g!#(B

$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%A%b!D(B3.0g,$BF|6I%+%s%>%&!D(B1.0g,$B%5%s%=%&%K%s!D(B10.0g
104 $B%D%`%i?I0P@6GYEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$s$$$;$$$O$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI!$E$^$j!"K}@-I!1j!"C_G?>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"G?@-I!O3!"8eI!O3$J$I$rH<$&I!<@45$KMQ$$$k!#(B
$B#1!K45It$KG.465Z$SaVDK$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B:nMQ5!=x(B
$B!!!!931j>I:nMQ!J(Bin vitro$B!K(B

$BF|6I%;%C%3%&!D(B5.0g,$BF|6I%P%/%b%s%I%&!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%5%s%7%7!D(B3.0g,$BF|6I%A%b!D(B3.0g,$BF|6I%7%g%&%^!D(B1.0g,$B%S%c%/%4%&!D(B3.0g,$B%7%s%$!D(B2.0g,$B%S%o%h%&!D(B2.0g,
105 $B%D%`%iDLF3;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$D$&$I$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j2I(B:$B7n7PIT=g!"7n7PDK!"99G/4|=}32!"9xDK!"JXHk!"BG$A?H(B($BBGKP(B)$B!"9b7l05$N?oH<>I>u(B($BF,DK!"$a$^$$!"8*$3$j(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!"BNNO$H$b$K=<l9g$KMQ$$$k!#(B
$B#1!KEm3K>55$Er$KHf$Y!"@:?@?@7P>I>u$,$h$j7c$7$$>l9g!#(B
$B#2!KF,DK!"$N$\$;!"ITL2!"IT0B$J$I$N@:?@?@7P>I>u$rH<$&>l9g!#(B
$B#3!K7n7PIT=g!"7n7P:$Fq>I$J$I$N$"$kIX?M!#(B

$BF|6I%-%8%D!D(B3.0g,$BF|6I%@%$%*%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%3%&%+!D(B2.0g,$BF|6I%3%&%\%/!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%b%/%D%&!D(B2.0g,$B%=%\%/!D(B2.0g,$BL5?e%\%&%7%g%&!D(B1.8g
106 $B%D%`%i297PEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$&$s$1$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI(B:$B7n7PIT=g!"7n7P:$Fq!"$3$7$1!"99G/4|=}32!"ITL2!"?@7P>I!"<>?>!"B-9x$NNd$(!"$7$b$d$1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?Nd$(>I$N?M$G!"8$N$[$F$j!"8}?0$N4%Ag!"2l9g$KMQ$$$k!#(B
$B#1!K@-4o=P7l!"7n7P0[>o!"ITG%$J$I$N$"$kIX?M!#(B
$B#2!K>e5->I>u$O!"@-<~4|$K4XO"$7$F>CD9$9$k$3$H$,B?$$!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%GSMqM6H/:nMQ!J%i%C%H!K(B
$B#2!%:nMQ5!=x(B
$B!!!!!!!!%[%k%b%s$KBP$9$k:nMQ!J%i%C%H!"(Bin vitro$B!K(B

$BF|6I%P%/%b%s%I%&!D(B4.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%\%?%s%T!D(B2.0g,$BF|6I%4%7%e%f!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%"%-%g%&!D(B2.0g
107 $B%D%`%i5m $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$7$c$8$s$-$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BHh$l$d$9$/$F!";M;h$,Nd$($d$9$/G"NL8:>/$^$?$OB?G"$G;~$K8}3i$,$"$kI(B:$B2<;hDK!"9xDK!"$7$S$l!"O7?M$N$+$9$_L\!"$+$f$_!"GSG":$Fq!"IQG"!"$`$/$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$"$k$$$OO7?M$G9xIt$*$h$S2<;h$NC&NO46!"Nd$(!"$7$S$l$J$I$,$"$j!"GSG"$N0[>o!JFC$KLk4V$NIQG"!K$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K>eJ"It$K$/$i$Y$F2l9g!JgA2 $B#2!KB?G"!"IQG"!"K3G"!"GSG"DK$J$I$rH<$&>l9g!#(B
$B#3!KHhO+7qBU46!"9xDK!"8}3i$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%?e>=BN:.By$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%?@7PEAF3B.EY$KBP$9$k:nMQ!J%i%C%H!K(B
$B#3!%93?/32 $B#4!%7lN.NLA}2C:nMQ!J%i%C%H!K(B
$B#5!%:nMQ5!=x(B
$B!!#1!K?e>=BN:.By$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!#2!K93?/32 $B!!#3!K7lN.NLA}2C:nMQ!J%i%C%H!K(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%4%7%D!D(B3.0g,$BF|6I%5%s%7%e%f!D(B3.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B3.0g,$BF|6I%1%$%R!D(B1.0g,$B=$<#%V%7Kv!D(B1.0g
108 $B%D%`%i?M;2M\1IEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$s$8$s$h$&$($$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIB8e$NBNNODc2
$B-"!V;HMQL\I8!a>Z!W(B
$BIB8e!&=Q8e$"$k$$$OK}@-<@45$J$I$GHhO+?jl9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"4i?'ITNI!"?)M_IT?6$J$I$rH<$&$3$H$,B?$$!#(B
$B#2!KK}@-<@45$G!"HyG.!"0-46!"31SV$J$I$rH<$&>l9g!#(B

$BF|6I%8%*%&!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%S%c%/%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%1%$%R!D(B2.5g,$BF|6I%*%s%8!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%4%_%7!D(B1.0g
109 $B%D%`%i>. $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$5$$$3$H$&$+$-$-$g$&$;$C$3$&(B
$B-!!V8zG=!&8z2L!W(B
$B0v9"$,$O$l$FDK$`I!'Y(Em1j!"Y(Em<~0O1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"HyG.$,$"$j!"?4c]It$h$j5(O>It$K$+$1$F$N6lK~46!"05Gw46!J6;OF6lK~!K!"?)M_IT?6$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K>e5$F;$N0!5^@-$J$$$7K}@-$N1j>I@-<@45!#(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%5%$%3!D(B7.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%-%-%g%&!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
110 $B%D%`%iN)8z;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$C$3$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BH4;u8e$NaVDK!";uDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$B;uDK!";u:,DK$*$h$S8}9PFb$N
$BF|6I%5%$%7%s!D(B2.0g,$BF|6I%7%g%&%^!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%j%e%&%?%s!D(B1.0g
111 $B%D%`%i@6?4O!;R0{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$7$s$l$s$7$$$s(B
$B-!!V8zG=!&8z2L!W(B
$BA4?H7qBU46$,$"$j!"8}$d@e$,4%$-!"G"$,=P$7$V$k$b$N$NI(B:$B;DG"46!"IQG"!"GSG"DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$h$j0_D25ul9g$KMQ$$$k!#(B
$B#1!KNd$(>I$G?@7P $B#2!KK}@-$NHgG"4o<@45$KH<$&>l9g!#(B

$BF|6I%P%/%b%s%I%&!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%*%&%.!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%l%s%K%/!D(B4.0g,$B%8%3%C%T!D(B2.0g
112 $B%D%`%iCvNjEr9g;MJ*Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$l$$$H$&$4$&$7$b$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHiIf$,8OAg$7!"?'$D$d$N0-$$BNc32$N$J$$?M$NI(B:$BGSG":$Fq!"GSG"DK!";DG"46!"IQG"(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G!"IQG"!";DG"46!"GSG"DK$J$I$NGSG">c32$,K}@-2=$7$?$j!"H?I|$7$F5/$3$k>l9g$KMQ$$$k!#(B
$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$B%"%-%g%&!D(B3.0g,$B%+%C%;%-!D(B3.0g
113 $B%D%`%i;02+_C?4Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$s$*$&$7$c$7$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"$N$\$;5$L#$G!"4iLL9HD,$7!"@:?@IT0B$G!"JXHk$N798~$N$"$k$b$N$NI(B:$B9b7l05$N?oH<>I>u(B($B$N$\$;!"8*$3$j!"<*$J$j!"F,=E!"ITL2!"IT0B(B)$B!"I!7l!"<&=P7l!"JXHk!"99G/4|=}32!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!&BNNO$H$b$K=<l9g$KMQ$$$k!#(B
$B#1!K5$J,$,$$$i$$$i$7$FMn$ACe$+$:!"@:?@IT0B$dITL2$rAJ$($k>l9g!#(B
$B#2!K?4c]It$NKDK~46$rAJ$($k>l9g!#(B
$B#3!KI!=P7l!"2<7l$J$I$N$"$k>l9g!#$?$@$7!"=P7l$,D9$S$$$FIO7l$NCx$7$$>l9g$K$OMQ$$$J$$!#(B

$B-#!VLt8z!&LtM}!W(B
$B:nMQ5!=x(B
$B!!!!#1!%7l059_2<:nMQ!J(Bin vitro$B!K(B
$B!!!!#2!%Cf?u?@7P7O$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%*%&%l%s!D(B3.0g,$BF|6I%@%$%*%&!D(B3.0g
114 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BEG$-5$!"?)M_IT?6!"$N$I$N$+$o$-!"GSG"$,>/$J$$$J$I$NI!'?e_C@-2
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?4c]It$h$j5(O>It$K$+$1$F$N6lK~46!"$J$i$S$KDq93!&05DK!J6;OF6lK~!K$,$"$j!"G"NL8:>/!"Ibl9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%MxG":nMQ!J%i%C%H!K(B
$B#2!%931j>I:nMQ!J%i%C%H!"%^%&%9!K(B
$B#3!%:nMQ5!=x(B
$B!!!!!!MxG":nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B7.0g,$BF|6I%?%/%7%c!D(B5.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
115 $B%D%`%i0_NjEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$$$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?e_C@-$N2/$rH<$&I(B:$B?)$"$?$j!"=k5$$"$?$j!"Nd$(J"!"5^@-0_D21j!"J"DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?4c]It$K?6?e2;$rG'$a!"?eMM@-$N2l9g$KMQ$$$k!#(B
$B#1!KJ"ItKDK~46!"7ZEY$NJ"DK!"G"NL8:>/$J$I$rH<$&>l9g!#(B
$BF|6I%3%&%\%/!D(B2.5g,$BF|6I%=%&%8%e%D!D(B2.5g,$BF|6I%?%/%7%c!D(B2.5g,$BF|6I%A%g%l%$!D(B2.5g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%S%c%/%8%e%D!D(B2.5g,$BF|6I%V%/%j%g%&!D(B2.5g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g,$BF|6I%?%$%=%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g
116 $B%D%`%ih*Nj0{9gH>2F8|KQEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$V$/$j$g$&$$$s$4$&$O$s$2$3$&$\$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5$J,$,$U$5$$$G!"0v9"!"?)F;It$K0[J*46$,$"$j!";~$KF0X)!"$a$^$$!"SR5$!"6;$d$1$J$I$,$"$j!"G"NL$N8:>/$9$k$b$N$NI(B:$BIT0B?@7P>I!"?@7P@-0_1j!"$D$o$j!"N/0{!"0_1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$G!"M^$&$D>uBV$rDh$7!"0v9"It$N0[J*46!"0_ItKDK~46$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K$a$^$$!"F0X)!"0-?4!"?4c]It?6?e2;$J$I$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%-%8%D!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g$B!!(B
117 $B%D%`%ih!DD8^Nj;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$$$s$A$s$4$l$$$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$N$I$,3i$$$F!"G"$,>/$J$$$b$N$NI(B:$BSREG!"$8$s$^$7$s!"FsF|?l$N$`$+$D$-!"$`$/$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"8}3i!"G"NL8:>/!"Ibl9g$KMQ$$$k!#(B

$BF|6I%?%/%7%c!D(B6.0g,$BF|6I%=%&%8%e%D!D(B4.5g,$BF|6I%A%g%l%$!D(B4.5g,$BF|6I%V%/%j%g%&!D(B4.5g,$BF|6I%1%$%R!D(B2.5g,$B%$%s%A%s%3%&!D(B4.0g
118 $B%D%`%iNjU*[24EEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$g$&$-$g$&$8$e$D$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B9x$KNd$($HDK$_$,$"$C$F!"G"NL$,B?$$I(B:$B9xDK!"9x$NNd$(!"LkG">I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$,Dc2<$7$??M$G!"9xIt$h$j2<;h$K$+$1$F$NNd$($,82Cx$G!"IQG"$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KNd$($N$?$a$K9x2<;h$KaVDK$rAJ$($k$3$H$b$"$k!#(B

$BF|6I%V%/%j%g%&!D(B6.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$B%+%s%-%g%&!D(B3.0g
119 $B%D%`%iNj4EU*L#?I2F?NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$g$&$+$s$-$g$&$_$7$s$2$K$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIO7l!"Nd$(>I$GSCLD$rH<$&S=ab$NB?$$31SV2j$"$k$b$N!#5$4I;Y1j!"5$4I;YSCB)!"?4B!?j
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$,Dc2<$7!"Nd$(>I$GIO7l798~$K$"$k?M$N!"SCLD!"31SV!"S=ab!"?eMM@-I!=A$J$I$rDh$9$k>l9g$KMQ$$$k!#(B
$B#1!K0_D25uc32$J$I$rDh$9$k>l9g!#(B
$B#2!KHhO+7qBU46!"F0X)!"B)@Z$l!"Ibl9g!#(B
$B#3!KJ"It$,Fpl9g!#(B

$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%4%_%7!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%5%$%7%s!D(B2.0g,$B%+%s%-%g%&!D(B2.0g
120 $B%D%`%i2+O"Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$&$l$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_It$NDdBZ46$d=E0546!"?)M_IT?6$N$"$k$b$N$NI(B:$B5^@-0_1j!"FsF|?l!"8}Fb1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY0J>e$N?M$G!">eJ"ItDK!"0-?4!"SREG$,$"$j!"?4c]It$KDq93$NG'$a$i$l$k>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$NDdBZ46$d=E0546!"?)M_IT?6$J$I$rH<$&>l9g!#(B
$B#2!K@e$K2+?'B]!"Kt$OGrB]$,$"$j!"8}=-$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%*%&%l%s!D(B3.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$B%+%s%-%g%&!D(B3.0g
121 $B%D%`%i;0J*2+:#Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$s$b$D$*$&$4$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"l9g$KMQ$$$k!#(B
$B#1!Kl9g!#(B
$B#2!K8}3i$rH<$&>l9g!#(B
$B#3!K8!"B-m($NG.46!"GBaZ46!"4%Ag!"H/@V$J$I$rH<$&>l9g!#(B
$BF|6I%8%*%&!D(B6.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%/%8%s!D(B3.0g
122 $B%D%`%iGSG?;65ZEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$$$N$&$5$s$-$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B45It$,H/@V!"I!"ag!"$;$D!"LLD#!"$=$NB>$;$D

I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$N2=G?@-HiIf<@455Z$S;uAeG?O3!";u:,1j$J$I$KMQ$$$k!#(B

$BF|6I%-%-%g%&!D(B4.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%-%8%D!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
123 $B%D%`%iEv5"7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHhO+$7$d$9$/!"7l?'$N$9$0$l$J$$$b$N$NI(B:$B7n7PDK!"2
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$G!"HhO+$7$d$9$/!"4i?'ITNI!"l9g$KMQ$$$k!#(B
$B#1!K@-4o=P7l!"<&=P7l$J$I$rH<$&>l9g!#(B
$B#2!KJ"It$,FpB&$NJ"D>6Z$,Z;5^$7$F$$$k>l9g!#(B
$B#3!Ke5->I>u$r;}$DIX?M$KMQ$$$i$l$k!#(B

$BF|6I%7%c%/%d%/!D(B5.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
124 $B%D%`%i@n5]CcD4;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$s$-$e$&$A$c$A$g$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$+$I!"F,DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$N6/ $B#1!K46KA$G$O=i4|$G!"F,DK$NB>!"0-46!"H/G.!"4X@aDK$J$I$N$"$k>l9g!#(B

$BF|6I%3%&%V%7!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%1%$%,%$!D(B2.0g,$BF|6I%O%C%+!D(B2.0g,$BF|6I%S%c%/%7!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%-%g%&%+%D!D(B2.0g,$B%A%c%h%&!D(B1.5g
125 $B%D%`%i7K;^h*Nj4]2C0Ugo?N(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$V$/$j$g$&$,$s$+$h$/$$$K$s(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!";~$K2I(B:$B7n7PIT=g!"7l$NF;>I!"$K$-$S!"$7$_!"
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"$N$\$;$F@V$i4i$N$3$H$,B?$/!"2I>u$rG'$a!J7K;^h*Nj4]$N;HMQL\I8!K!"$5$i$KHiIf>I>u$,$"$k>l9g$KMQ$$$k!#(B
$B#1!KH)$N$"$l!"4NHC!":Bal!"aOlT$J$I$NHiIf>I>u$rH<$&>l9g!#(B
$B#2!KF,DK!"8*$3$j!"$a$^$$!"$N$\$;!"B-$NNd$($J$I$rH<$&>l9g!#(B
$B#3!KL57n7P!"2aB?7n7P!"7n7P:$Fq>I$J$I$N7n7P0[>o$N$"$kIX?M!#(B

$BF|6I%h%/%$%K%s!D(B10.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%H%&%K%s!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%\%?%s%T!D(B4.0g
126 $B%D%`%iKc;R?N4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$7$K$s$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$N=,47@-JXHk$G!"O7?M$dIB8e$N5u $B#1!KBgJX$O9E$/!"2t>u$rDh$9$k$3$H$,B?$$!#(B

$BF|6I%@%$%*%&!D(B4.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%-%g%&%K%s!D(B2.0g,$BF|6I%3%&%\%/!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$B%^%7%K%s!D(B5.0g
127 $B%D%`%iKc2+Im;R:Y?IEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$*$&$V$7$5$$$7$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0-4(!"HyG.!"A4?H7qBU!"Dc7l05$GF,DK!"$a$^$$$,$"$j!";M;h$KaVDKNd46$"$k$b$N$NI(B:$B46KA!"5$4I;Y1j!#(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$N0-4($rH<$&H/G.!JHyG.!K$rL\I8$KMQ$$$k!#L.$OD@$s$G:Y$/!"NO$,$J$$$3$H$,B?$$!#O7?M$d5u $B#1!KL55$NO46!"A4?H7qBU46$J$I$rH<$&>l9g!#(B
$B#2!KF,DK!"31SV!"$N$I$NDK$_!"%/%7%c%_!"?eMM@-I!=A!"l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%931j>I:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!%93?/32 $B#3!%:nMQ5!=x(B
$B!!!!!!93?/32
$BF|6I%^%*%&!D(B4.0g,$BF|6I%5%$%7%s!D(B3.0g,$B=$<#%V%7Kv!D(B1.0g
128 $B%D%`%i7 $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$R$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$d$;$F!"4i?'$,0-$/!"?)M_$,$J$/!"2I(B:$B0_D25uC2=ITNI!"2
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$F$$$k?M$N2u$OE%>u$J$$$7$O?eMM$G$"$k>l9g$,B?$$!#(B
$B#1!K?)M_IT?6!"SREG!"J"DK$J$I$rH<$&>l9g!#(B
$B#2!KJ"It$,Fpl9g!#(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%?%/%7%c!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$B%l%s%K%/!D(B3.0g,$B%5%s%6%7!D(B2.0g
133 $B%D%`%iBg>55$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$8$g$&$-$H$&(B
$B-!8zG=!&8z2L!W(B
$BJ"It$,$+$?$/$D$+$($F!"JXHk$9$k$b$N!"$"$k$$$OHnK~BNo=,JXHk!"5^@-JXHk!"9b7l05!"?@7P>I!"?)Ev$j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$N=<l9g$KMQ$$$k!#(B
$B#1!KIT0B!"ITL2!"6=J3$J$I$N@:?@>I>u$rH<$&>l9g!#(B

$BF|6I%3%&%\%/!D(B5.0g,$BF|6I%-%8%D!D(B3.0g,$BF|6I%@%$%*%&!D(B2.0g,$BL5?e%\%&%7%g%&!D(B1.3g
134 $B%D%`%i7K;^2CgiLtBg2+Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$7$c$/$d$/$@$$$*$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$N$J$$?M$G!"J"ItKDK~$7!"D2Fb$NDdBZ46$"$k$$$OJ"DK$J$I$rH<$&$b$N$NI(B:
1.$B5^@-D21j!"BgD2%+%?%k(B
2.$B>o=,JXHk!"=IJX!"$7$V$jJ"(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"J"ItKDK~$7!"J"DK$,$"$j!"N"5^8e=E$rH<$&2l9g$KMQ$$$k!#(B
$B#1!KJX0U$r:E$9$,!"2w$/GSJX$7$J$$>l9g!#(B
$B#2!K2<:^I~MQ8e$NJ"DK!#(B
$B#3!K3+J"=Q8e$KJX$N2wDL$7$J$$>l9g!#(B

$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%@%$%*%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
135 $B%D%`%ih!DDhfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$$$s$A$s$3$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BG"NL8:>/!"$d!5JXHk$,$A$GHf3SE*BNNO$N$"$k$b$N$NI(B:$B2+aU!"4N9EJQ>I!"%M%U%m!<%
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!">eJ"It$h$j6;It$K$+$1$F$NKDK~46!"IT2w46$rAJ$(!"0-?4!"JXHk$rH<$&>l9g$KMQ$$$k!#(B
$B#1!K2+aU$N$"$k>l9g!#(B
$B#2!K8}3i!"G"NL8:>/!"HiIfGBaZ46$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%4N>c32$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!%MxC@:nMQ!J%i%C%H!K(B
$B#3!%:nMQ5!=x!!(B
$B!!!!!!!!4N>c32$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%5%s%7%7!D(B3.0g,$BF|6I%@%$%*%&!D(B1.0g,$B%$%s%A%s%3%&!D(B4.0g
136 $B%D%`%i@6=k1W5$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$7$g$($C$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B=k5$$"$?$j!"=k$5$K$h$k?)M_IT?6!&2
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"?)M_IT?6!"A4?H7qBU46$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KFpJX!"G"NL8:>/!"<+A3H/4@!"l9g!#(B
$B#2!K$$$o$f$k2F$d$;!"2F$^$1$KB?MQ$5$l$k!#(B

$BF|6I%=%&%8%e%D!D(B3.5g,$BF|6I%K%s%8%s!D(B3.5g,$BF|6I%P%/%b%s%I%&!D(B3.5g,$BF|6I%*%&%.!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%P%/!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%4%_%7!D(B1.0g
137 $B%D%`%i2CL#5"g#Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$_$-$R$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$BIO7l!"ITL2>I!"@:?@IT0B!"?@7P>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNI>u$rAJ$(!"HyG.$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K2<7l!"EG7l!"I!=P7l$J$I$rH<$&>l9g!#(B
$B#2!KEp4@!"A4?H7qBU46!"?)M_IT?6$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B93IT0B:nMQ!J%^%&%9!K(B

$BF|6I%*%&%.!D(B3.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%s%8!D(B2.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%b%C%3%&!D(B1.0g,$B%5%s%=%&%K%s!D(B3.0g,$B%j%e%&%,%s%K%/!D(B3.0g
138 $B%D%`%i5K9 $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$-$-$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0v9"$,$O$l$FDK$`I(B:$BY(Em1j!"Y(Em<~0O1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$B0v!&9"It$N1j>I$G!"aVDK!"l9g$KMQ$$$k!#(B
$B#1!K7ZEY$NH/G.!"31SV!"S=ab!"Sk2<:$Fq$J$I$rH<$&$3$H$,B?$$!#(B

$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%-%-%g%&!D(B2.0g
3020 $B%D%`%i$N@8Lt(B
$B%3%&%8%sKv(B($BD4:^MQ(B)
$B-!!V8zG=!&8z2L!W(B
$B4AJ}=hJ}$ND4:^$KMQ$$$k(B

$B!!(B
3021 $B%D%`%i$N@8Lt(B
$B=$<#%V%7Kv(B($BD4:^MQ(B)
$B-!!V8zG=!&8z2L!W(B
$B4AJ}=hJ}$ND4:^$KMQ$$$k(B

$B!!(B
501 $B%D%`%i;g1@9Q(B
$B$7$&$s$3$&(B
$B-!!V8zG=!&8z2L!W(B
$B2P=}!"<&3K$K$h$kaVDK!"fjLgNu=}(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"J,HgJ*$N>/$J$$>l9g$KMQ$$$k!#(B
$B#1!K2P=}!"<&3K$K$h$kaVDK!"fjLgNv=}$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$BAO=}<#L~B%?J:nMQ!J%i%C%H!"%^%&%9!K(B

$BF|6I%4%^L}!D(B100.0g,$BF|6I%7%3%s!D(B10.0g,$BF|6I%H%&%-!D(B10.0g$B!!F|6I%5%i%7%_%D%m%&!D(B27.0g,$BF|6IFZL}!D(B1.8g

$BCm0U!K>e5-4AJ}Lt$r#2=54VI~MQ$7$F$b8z2L$KK~B-$G$-$J$$>l9g$O!"Bg;34AJ}$ND49g4AJ}Lt!J%*!<%@!<%a%$%I!K$r$*4+$a$7$^$9!*(B
$BBg;34AJ}F2Lt6I$K!"0lEY!"$*EEOC$/$@$5$$!#(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B


$B!!(B$B!!(B

$B!!(B $B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B


$BBg;34AJ}F2Lt6I(B WEB-SITE $B!!(BTEL: 0283-22-1574
$BBg;3o*5d1!(B WEB-SITE $B!!(BTEL: 0283-22-1389
$BBg;3=!GlElMN0e3X5-G04[(B WEB-SITE
$BBg;3=!GlElMN0e3X5-G04[o*5d<#NE<<(B WEB-SITE
$BNW>2?4M}3X(B $B?4$N7r9/AjCL<<(B WEB-SITE$B!!(BTEL: 0283-22-1607

$B")(B327-0026$B!!FJLZ8):4Ln;T6b20CgD.#2#4#3#2!!(BTEL: 0283-22-1574$B!JBeI=!K(B
E-mail to ohyama@poem.ocn.ne.jp



$BBg;3=!GlElMN0e3X5-G04[!JElMN0e3X!"4AJ}Lt!"o*5d!"NW>2?4M}3X!K(B

President & Chairman
Meister of Medical Science
Dr. HIROYUKI OHYAMA $B!J(BPh.D$B!K(B.

$B2,;3Bg3X(B $B0e3XGn;N!!FAEgBg3X(B $BLt3X=$;N(B
$BBg;3Gn9T(B



$BBg;34AJ}F2Lt6I%V%i%s%I>&IJ$N$4>R2p!!?M5$$H?.Mj$N#3IJL\(B



$BBg;34AJ}F2Lt6I%V%i%s%I>&IJ$N$4>R2p!!?M5$$H?.Mj$N#3IJL\(B
$BKL3$F;$+$i!"6e=#!"2-Fl8)$N?M$^$G!"F|K\A49q$KBg;34AJ}$N%U%!%s$NJ}$,$$$i$C$7$c$$$^$9!*(B
$B!VBg;34AJ}$N@y$8Lt$O$9$4$$!*Bg;34AJ}$N$3$l$,$h$$!*!W$H$*$C$7$c$C$F$$$?$@$$$F$*$j$^$9!#(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

keywords
$BBg;34AJ}F2Lt6I!!4AJ}Lt!!4AJ}Lt6I!!4AJ}@lLg!!4AJ}@lLgLt6I!!4AJ}Lt@lLg!!4AJ}Lt@lLgLt6I!!Bg;34AJ}F2Lt6I!!Bg;3o*5d1!(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B


$B!!(B$B!!(B

$BJ?AG$h$j!"Bg;3=!GlElMN0e3X5-G04[(B Web-Page $B$r!"$40&8\$$$?$@$-!"@?$K$"$j$,$H$&$4$6$$$^$9!#(B
$B$5$F!"Bg;34AJ}F2Lt6I$N%W%m%P%$%@$G$"$k(BNTT$B%3%_%e%K%1!<%7%g%s%:(B(NTT Com)$B$,!"(B
2015$BG/(B2$B7n(B28$BF|$r$b$A$^$7$F!"(BOCN$B%[!<%`%Z!<%8%5!<%S%9!J(BPage ON$B!K$r=*N;CW$7$^$9!#(B
$B$3$l$KH<$$!"Bg;3=!GlElMN0e3X5-G04[$G$O!"(B2015$BG/(B3$B7n(B1$BF|$h$j!"$5$/$i%$%s%?!<%M%C%H $B!V$5$/$i$N%l%s%?%k%5!<%P!<(BSTD$B!W$K!"0\9T$9$k1?$S$H$J$j$^$7$?!#(B

$B?7$7$$!"Bg;34AJ}F2Lt6I$N%[!<%`%Z!<%8(BURL$B$O!"(B

http://ohyama-campany.com/

http://ohyama-kampo.tokyo/

$B$K$J$j$^$9!#(B

$B$*5RMMJ}$K$O!"BgJQ$4LBOG$r$*$+$1$7$F!"?=$7Lu$"$j$^$;$s$,!"(B
$B2?B4!"$4M}2r$$$?$@$1$^$9$h$&!"$*4j$$?=$7>e$2$^$9!#(B
$B:#8e$H$b!"Bg;3=!GlElMN0e3X5-G04[(B WEB-Page $B$r!"$h$m$7$/$*4j$$CW$7$^$9!#(B

$BBg;3=!GlElMN0e3X5-G04[(B
$BBg;34AJ}F2Lt6I%9%?%C%U0lF1(B


$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B


$B$*Ld$$9g$o$;$O!"(B
$B4AJ}$r8=BeIB$K3h$+$9!*4AJ}@lLg!!Bg;34AJ}F2Lt6I(B
0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B
$B$^$G!"$*5$7Z$K$*Ld$$9g$o$;$/$@$5$$!#(B

$BBg;34AJ}F2Lt6I(B
$B4AJ}7r9/AjCL%3!<%J!<$X!"%/%j%C%/!*(B




$B:4LnLq=|$1Bg;UDL$j$N4AJ}@lLg!"Bg;34AJ}F2Lt6I!!(BWeb-Page $B$X!"#G#o!*!*!*(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B0eLtIJ$O;HMQ>e$NCm0U$r$*FI$_$$$?$@$-!"@5$7$/$*;H$$$/$@$5$$!#(B
$B$*Gc$$5a$a$N:]$K$O!"4AJ}$r8=BeIB$K3h$+$9(B $B4AJ}@lLg(B $BBg;34AJ}Lt6I$K!"$*5$7Z$K$4AjCL$/$@$5$$!#(B


$B!V%$%s%?!<%M%C%H$G8+$?!*!W(B
$B$H$*OC$/$@$5$$!#(B

$B!JCm0U!K(B
$B4AJ}@lLg!!Bg;34AJ}F2Lt6I$N!!87A*!"4AJ}Lt!"7r9/?)IJ$N$4CmJ8$O!"Bg;34AJ}Lt6I$K!"D>@\!"$*EEOC!"(BFAX$B!"(BE-mail $B$K$F$4MQL?$/$@$5$$!#(B
$B$*EEOC!'(B0283-22-1574$B!"(BFAX$B!'(B0283-22-1607$B!"(BE-mail:ohyama@poem.ocn.ne.jp
$B$*BT$ACW$7$F$*$j$^$9!#(B


$B!VBg;34AJ}F2(B $B4AJ}0e3X$H4AJ}7r9/AjCL!W(B

$B!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B

" THE KAMPO " $B4AJ}(B
$B!!4AJ}Lt(B, How the Japanese Updated Traditional Herbal Medicine


$B!c4AJ}Lt$N$4I~MQ$r$*9M$($N3'MM$X$N$*4j$$!*!d(B

$B!v4AJ}Lt$N$4I~MQ$K4X$7$^$7$F$O!"(B
$B!V;HMQ>e$NCm0U!W$r$h$/FI$_!"!VMQK!!&MQNL!W$r$h$/
$B$^$?!":#2s!";O$a$F!"4AJ}Lt$N$4I~MQ$r4uK>$5$l$k$*5RMM$O!"(B
$B2<5-!"Ld?GI=$KI,MW;v9`$r5-F~$7$FAw?.$9$k$+!"(B

$B4AJ}AjCL$*?=$79~$_%U%)!<%`(B

$B$*EEOC$K$F!"D>@\!"Bg;34AJ}Lt6I$K!"$4AjCL$/$@$5$$!#(B
$B>I>u!&BN\$7$/$*;G$$$7$?>e$G!"E,@Z$J4AJ}Lt$r%"%I%P%$%9$5$;$FD:$-$^$9!#(B

$B!JBg;34AJ}Lt6I(B / $BL5NA4AJ}AjCLEEOC(B $B#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4(B / $B#9!'#0#0!A#1#9!'#0#0!K(B

$B!cCm0U!d(B
$BBg;34AJ}Lt6I!"%G%8%?%kE9J^$G!"$*
$B0J>e!"$h$m$7$/$*4j$$CW$7$^$9!#(B

E-mail to Dr. Ohyama Kampo Pharmacy.


$B!!4AJ}$r8=BeIB$K3h$+$9!*!!4AJ}@lLg!!Bg;34AJ}Lt6I%G%8%?%kE9J^$X!*(B



$BBg;34AJ}F2Lt6I(B $B")(B327-0026$B!!FJLZ8):4Ln;T6b20CgD9D.#2#4#3#2(B
TEL$B!u(BFAX : 0283-22-1574$B!!(B E-mail : ohyama@poem.ocn.ne.jp


$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B!!(B$B!!(B