Institute of Natural Health Science
Oriental Medicine Research Center
Central Research Laboratories
General Manager
Dr. HIROYUKI OHYAMA (Ph.D)
岡山大学医学博士（分子細胞医学神経情報学）
徳島大学薬学修士（生物薬品化学）
Dr. HIROYUKI OHYAMA, Ph.D. Selfportrait in 1995 (Dec).
E-mail to Dr.Ohyama.1)
Age-related difference in synaptosomal membrane fluidity
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori
Biochemistry and Molecular Biology International 37,133-140,1995
Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical
School, 2-5-1 Shikatacho, Okayama 700, Japan and *Division of Medical Science, Institute for Life
Support Technology, Yamagata Technopolis Foundation, Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan
ACKNOWLEDGEMENTS
We thank Dr. Lester Packer of the University of California, Berkeley,
for reading our manuscript and providing us with valuable comments.
Special Thanks.
Dr. Lester Packer
Building 20 - 251 LSA
Energy & Environment Division
Lawrence Berkeley Laboratory
University of California
Berkeley, CA 94720
2)
Effect of Japanese herbal medicine(TJ-960) on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu, Akitane Mori
Magnetic Resonance in Medicine 6, 279-281, 1995
3)
Effect of Japanese herbal medicine(TJ-960), on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori
Lipid-Soluble Antioxidants:Biochemistry and Clinical Applications.
pp.535-552,Birkhauser Verlag,Basel,1992
4)
Combined treatment of Japanese herbal medicine(TJ-960)with low dose of dipropylacetate increased the latent time for
pentylenetetrazol induced convulsion and decreased brain lipid peroxidation in mice.
Hiramatsu,M., Liu J, Edamatsu,R., Kadowaki,D., Hamada,H., Ohyama,H., Watanabe,S., Mori,A.
Neuroscience 18, 71-76,1992
5)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H., Mori,A., Teraoka,H., Komaru,N.
in: The SAM Model of Senescence (T.Takeda, ed.) pp.343-346,Elsevier Science B.V., Amsterdam, 1994
6)
Age-related changes in nitric oxide content and nitric oxide synthase activity
in senescence-accelerated mouse (SAM P8) brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A., Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y., Nishijima,K.
in: Oxidative Stress and Aging (R.G.Cutler, L.Packer, J.Bertram, A.Mori, eds.)
pp387-391, Birkhauser Verlag, Basel, 1995
7)
UNESCO / Costam Workshop on Lipid-soluble Antioxidants in Biochemistry of Nutrition and Environmental Health
1991.9.21 (Malaysia)
Effect of Japanese herbal medicine(TJ-960), on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori
8)
Society for Free Radical Research 1991.9027 (Paris)
Japanese herbal medicine(TJ-960) affected free radicals, SOD activity,
lipid peroxidation and neurotransmitter in aged rat brain
Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori
9)
5th International Congress on Oxygen Radicals 1991.11.18 (Kyoto)
Decreased membrane fluidity in rat synaptosomes induced by active oxygen species,
guanidino compounds and convulsants
Midori Hiramatsu, Rei Edamatsu, Hajime Hamada, Hiroyuki Ohyama, Akitane Mori
10)
5th International Congress on Oxygen Radicals 1991.11.20 (Kyoto)
Antioxidant effects of the extracts of gastrodia fleta bl. and uncaria rhynchophylla (MJQ) jacks
Jiankang Liu, Hajime Hamada, Hiroyuki Ohyama, Akitane Mori.
11)
The First International Conference on Senescence: The SAM Model 1994.3.17 (Kyoto)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H., Mori,A., Teraoka,H., Komaru,N.
12)
The First International Conference on Oxidative Stress and Aging 1994.3.25 (Hawaii)
Age-associated changes in nitric oxide (NO) content and nitric oxide synthase (NOS) activity
in senescence accelerated mouse (SAM P8) brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A., Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y., Nishijima,K.
13)
International Conference on Bioradicals Detected by ESR Spectroscopy 1994.6.13 (Yamagata)
Effect of Japanese herbal medicine(TJ-960) on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu, Akitane Mori
14)
International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects (ISNA) 1995.6.21 (Beijin)
Antioxidant defenses of Japanese herbal medicine(TJ-960) , against free radical induced neural cell damages
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara
Reference
1)
Mixed Japanese Herbs and Age-Related Neuronal Functions
Midori Hiramatsu and Makiko Komatsu
Antioxidant Food Supplements in Human Health,edited by Lester Packer,
Midori Hiramatsu,Toshikazu Yoshikawa,pp.412-428,1999
2)
Effects of Japanese herbal medicine(TJ-960), on neuronal membrane fluidity of mice
Hiroyuki Ohyama,Midori Hiramatsu,Rei Edamatsu,Akitane Mori.
Magnetic Resonance in Medicine 6,279-281,1995
3)
Antioxidant effect of TJ-960, a Japanese herbal medicine, against free radical-induced neuronal cell damage
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara
International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects(ISNA),pp.45-53.1996
4)
Effect of TJ-960 on generalized seizure in amygdaloid kindled cats
Susumu Iizuka, Atsushi Ishige, Kyoji Sekiguchi, Akira Sugimoto, Kouichi Itoh, Masaki Aburada, Eikichi Hosoya, Eiichi Sugaya
Recent Advances in the Pharmacology of Kampo Medicines pp.62-68,1988
5)
Normalizing effect of SK commercial formula on cytochalasin-B distorted neurites using primary cultured neurons of rat cerebeal cortex
Aiko Sugaya, Mitsutoshi Yuzurihara, Tadashi Tsuda, Eiichi Sugaya
J. Ethnopharmacol., 21: 193-199,1987.
6)
Effect of Kampo Medicine Preparations Using the Pathological Model of Dementia
Michihiro Fujiwara
Brain Research Conference for Japanese Kampo Medicine pp.67-81,1990
7)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain
Habu,H.,Yokoi,I.,Kabuto,H.,Ohyama,H.,Mori,A.,Teraoka,H.,Komaru,N.
The SAM Model of Senescence(T.Takeda,ed.) pp.343-346,
Elsevier Science B.V.,Amsterdam,1994
8)
Mixed Natural Antioxidants
Hiramatsu,M.
Food and Free Radicals,edited by Hiramatsu et al.
Plenum Press,New York,pp.113-117,1997
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