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'sohhaku OHYAMA' memorial
Institute of Natural Health Science
Oriental Medicine Research Center
Central Research Laboratories
Dr. Hiroyuki Ohyama, Ph.D.
selfportrait in 1999 (April).
General Manager
Dr. HIROYUKI OHYAMA (Ph.D)
岡山大学医学博士(分子細胞医学神経情報学)
徳島大学薬学修士(生物薬品化学)
' Model of DNA in combined wire and space
filling forms.'
1)
Age-related difference in synaptosomal membrane
fluidity
Hiroyuki Ohyama, Midori Hiramatsu, Norio
Ogawa, Akitane Mori
Biochemistry and Molecular Biology International
37,133-140,1995
Department of Neuroscience, Institute of
Molecular and Cellular Medicine, Okayama
University Medical
School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute
for Life
Support Technology, Yamagata Technopolis
Foundation, Yamagata 683 Kurumanomae, Numagi,
Yamagata 990, Japan
2)
Effect of Japanese herbal medicine(TJ-960)
on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu,
Akitane Mori
Magnetic Resonance in Medicine 6, 279-281,
1995
3)
Effect of Japanese herbal medicine(TJ-960),
on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki
Ohyama, Akitane Mori
Lipid-Soluble Antioxidants:Biochemistry and
Clinical Applications.
pp.535-552,Birkhauser Verlag,Basel,1992
4)
Combined treatment of Japanese herbal medicine(TJ-960)with
low dose of dipropylacetate increased the
latent time for
pentylenetetrazol induced convulsion and
decreased brain lipid peroxidation in mice.
Hiramatsu,M., Liu J, Edamatsu,R., Kadowaki,D.,
Hamada,H., Ohyama,H., Watanabe,S., Mori,A.
Neuroscience 18, 71-76,1992
5)
Estimation of nitric oxide and nitric oxide
synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H.,
Mori,A., Teraoka,H., Komaru,N.
in: The SAM Model of Senescence (T.Takeda,
ed.) pp.343-346,Elsevier Science B.V., Amsterdam,
1994
6)
Age-related changes in nitric oxide content
and nitric oxide synthase activity
in senescence-accelerated mouse (SAM P8)
brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A.,
Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y.,
Nishijima,K.
in: Oxidative Stress and Aging (R.G.Cutler,
L.Packer, J.Bertram, A.Mori, eds.)
pp387-391, Birkhauser Verlag, Basel, 1995
7)
UNESCO / Costam Workshop on Lipid-soluble
Antioxidants in Biochemistry of Nutrition
and Environmental Health
1991.9.21 (Malaysia)
Effect of Japanese herbal medicine(TJ-960),
on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki
Ohyama, Akitane Mori
8)
Society for Free Radical Research 1991.9027
(Paris)
Japanese herbal medicine(TJ-960) affected
free radicals, SOD activity,
lipid peroxidation and neurotransmitter in
aged rat brain
Midori Hiramatsu, Rei Edamatsu, Hiroyuki
Ohyama, Akitane Mori
9)
5th International Congress on Oxygen Radicals
1991.11.18 (Kyoto)
Decreased membrane fluidity in rat synaptosomes
induced by active oxygen species,
guanidino compounds and convulsants
Midori Hiramatsu, Rei Edamatsu, Hajime Hamada,
Hiroyuki Ohyama, Akitane Mori
10)
5th International Congress on Oxygen Radicals
1991.11.20 (Kyoto)
Antioxidant effects of the extracts of gastrodia
fleta bl. and uncaria rhynchophylla (MJQ)
jacks
Jiankang Liu, Hajime Hamada, Hiroyuki Ohyama,
Akitane Mori.
11)
The First International Conference on Senescence:
The SAM Model 1994.3.17 (Kyoto)
Estimation of nitric oxide and nitric oxide
synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H.,
Mori,A., Teraoka,H., Komaru,N.
12)
The First International Conference on Oxidative
Stress and Aging 1994.3.25 (Hawaii)
Age-associated changes in nitric oxide (NO)
content and nitric oxide synthase (NOS) activity
in senescence accelerated mouse (SAM P8)
brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A.,
Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y.,
Nishijima,K.
13)
International Conference on Bioradicals Detected
by ESR Spectroscopy 1994.6.13 (Yamagata)
Effect of Japanese herbal medicine(TJ-960)
on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu,
Akitane Mori
14)
International Symposium on Natural Antioxidants:
Molecular Mechanisms and Health Effects (ISNA)
1995.6.21 (Beijin)
Antioxidant defenses of Japanese herbal medicine(TJ-960)
, against free radical induced neural cell
damages
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama,
Midori Hiramatsu, Seiichi Shinohara
Reference
1)
Mixed Japanese Herbs and Age-Related Neuronal
Functions
Midori Hiramatsu and Makiko Komatsu
Antioxidant Food Supplements in Human Health,edited
by Lester Packer,
Midori Hiramatsu,Toshikazu Yoshikawa,pp.412-428,1999
2)
Effects of Japanese herbal medicine(TJ-960),
on neuronal membrane fluidity of mice
Hiroyuki Ohyama,Midori Hiramatsu,Rei Edamatsu,Akitane
Mori.
Magnetic Resonance in Medicine 6,279-281,1995
3)
Antioxidant effect of TJ-960, a Japanese
herbal medicine, against free radical-induced
neuronal cell damage
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama,
Midori Hiramatsu, Seiichi Shinohara
International Symposium on Natural Antioxidants:
Molecular Mechanisms and Health Effects(ISNA),pp.45-53.1996
4)
Effect of TJ-960 on generalized seizure in
amygdaloid kindled cats
Susumu Iizuka, Atsushi Ishige, Kyoji Sekiguchi,
Akira Sugimoto, Kouichi Itoh, Masaki Aburada,
Eikichi Hosoya, Eiichi Sugaya
Recent Advances in the Pharmacology of Kampo
Medicines pp.62-68,1988
5)
Normalizing effect of SK commercial formula
on cytochalasin-B distorted neurites using
primary cultured neurons of rat cerebeal
cortex
Aiko Sugaya, Mitsutoshi Yuzurihara, Tadashi
Tsuda, Eiichi Sugaya
J. Ethnopharmacol., 21: 193-199,1987.
6)
Effect of Kampo Medicine Preparations Using
the Pathological Model of Dementia
Michihiro Fujiwara
Brain Research Conference for Japanese Kampo
Medicine pp.67-81,1990
7)
Estimation of nitric oxide and nitric oxide
synthase activity in SAMP8 mouse brain
Habu,H.,Yokoi,I.,Kabuto,H.,Ohyama,H.,Mori,A.,Teraoka,H.,Komaru,N.
The SAM Model of Senescence(T.Takeda,ed.)
pp.343-346,
Elsevier Science B.V.,Amsterdam,1994
8)
Mixed Natural Antioxidants
Hiramatsu,M.
Food and Free Radicals,edited by Hiramatsu
et al.
Plenum Press,New York,pp.113-117,1997
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4. Borchelt,D.R. et al. Familial Alzheimer's
disease-linked presenilin 1variants elevate
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(43) in brains of miceexpressing mutant presenilin
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amyloid beta42 with a gene-dosagedependent
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Alzheimer'sdisease. Nature Med. 2, 864-870
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for Notch and Dll1 expressionin the paraxial
mesoderm. Nature 387, 288-292 (1997).
10. Davis,J.A. et al. An Alzheimer's disease-linked
PS1 variant rescues thedevelopmental abnormalities
of PS1-deficient embryos. Neuron 20, 603-609(1998).
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M. D. (1993) Programmed cell death and the
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S.(1999) Paradigms of neurotrophic factor
action in regulating neuronal survival in
the developing nervous system. Taniguchi
Symposium, in press.
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R., Korsching, S., Rohrer, H. And Thoenen,
H. (1988) Timing and site of nerve growth
factor synthesis in developing skin in relation
to innervation and expression of the receptor.
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10) Buchman, V. L., and Davies, A. M.(1993)
Different neurotrophins are expressedand
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Neurotrophin autocrine loops. Curr. Biol.,
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(1998) Neurogenin1 is essential for the determination
of neuronal precursors for proximal cranial
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19) Fode, C., Gradwohl, G., Morin, X., Dierich,
A., LeMeur, M., Goridis, C. and Guillemot,
F. (1998) The bHLH protein NEUROGENIN 2 is
a determination factor for epibranchial placode-derived
sensory neurons. Neuron, 20:483-94
20) O'Connor, R. and Tessier-Lavigne, M.(1999)
Identification of maxillary factor, a maxillary
process-derived chemoattractant for developing
trigeminal sensory axons. Neuron, 24:165-178.
21) Lumsden, A. G., and Davies, A. M. (1983)
Earliest sinsory nerve fibers are guided
to peripheral targets by attractants other
than nerve growth factor. Nature,306:786-788.
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(1991) Target attraction: are developing
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